Senior Research Associate

Overview

Acuity Spatial Genomics, Inc. (a Bruker subsidiary) is focused on opening a new frontier in spatial 3D genomics and multiomic analyses. We are committed to the development of a novel technology platform allowing progress in genome-wide visualization of spatially resolved 3D chromosome and chromatin architecture in individual cells and cell populations in situ. The Company brings together the premier spatial omics approach (OligoFISSEQTM) with leading-edge imaging, data acquisition and analysis capability. The pioneering in situ technology enables examination of some of the most important questions in genomics and gene expression at the single cell and sub-cellular level. We aim to find the best talent in the field to join and contribute to this extraordinary, exciting endeavor becoming a critical member of this groundbreaking opportunity.

Responsibilities

Position description:

• The candidate will be a key contributor to optimization and development of advanced bioassays for determination of chromosome and chromatin architecture through the use of spatial omics approaches.
• This is a unique multi-disciplinary position that will work closely with a variety of disciplines including scientists and engineers with molecular biology, general wet lab, or imaging experience. As part of our team, you will conduct cutting edge experiments to map spatial gene activity and expression. You will support technique optimization in the leading approach in in situ imaging of gene activity, localization, and expression.
• The successful candidate will have demonstrated wet lab expertise and be enthusiastic to work as part of a team in a fast-paced startup environment.
• The ideal candidate should have experience working independently in a chemistry, biochemistry, or molecular biology laboratory, have exceptional attention to detail, and be able to critically analyze data and communicate results to the team. They must bring a can-do attitude and sense of purpose to the job.

Role:

• Support the method development and optimization of novel molecular biology assay schemes for spatial omic applications including molecular barcoding, fluorophore marking, nucleic acid hybridization, amplification and sequencing techniques, and probe library preparation.
• Support the optimization of sample preparation methods such as tissue/cell fixation and permeabilization.
• Support the optimization of probe chemistry and probe-based sequencing with spatial multi-omic profiling applications.
• Support the generation of test samples through cell culture and/or tissue preparation
• Prepare assay reagents and other components.
• Work within multidisciplinary teams at all stages of product development.
• Assist with research projects to profile spatial genomics. Collaborate with other team members on research studies.
• Support the development, verification and validation of product related kits and reagents.
• Analyze specimens on imaging instrumentation. Analyze research data and assist with data interpretation.
• Prepare research reports and share findings with the team. Write protocols, develop procedures, and maintain accurate records.
• Clearly communicate and present results; contribute data for making critical design decisions.

Qualifications

Educational/Experience requirements:

• BS/MS in molecular biology, biochemistry, cell biology, or a related field and 5+ years of hands-on molecular biology experience in an academic or industrial setting.
• Proficient in standard molecular biology techniques such as sample preparation, nucleic acid amplification and purification (RNA/DNA), qPCR, and DNA sequencing or similar molecular biology techniques. Experience with microscopy.
• Knowledge of advanced fluorescence in situ hybridization (FISH) or other in situ fluorescence probed-based techniques. Understanding of basic absorption and emission spectroscopy.
• Highly motivated with excellent attention to detail. Good communication (oral and written) and collaboration skills.
• Experience in cell culture and tissue preparation techniques.
• Experience in troubleshooting and optimization of molecular biology assays including reagent formulation and workflow optimization.
• Experience with experimental design and data analysis. Must be capable of performing complex multi-step experiments with detailed and diligent attention to technique and protocols with accurate record keeping.
• Desire to be part of a rapidly evolving organization, which requires real-time communication, flexibility, working well with others, and a willingness to learn new techniques and methods.

Additional desirable skills to have:

• Experience in product development including product release.
• Familiarity with basic statistical data and error analysis. Familiarity with single cell and/or spatial transcriptomics, fixation chemistry, Design of Experiments (DOE).
• Advanced fluorescence imaging techniques. Experience in microscopy image analysis.

The Company offers a comprehensive and competitive benefits package including medical, dental, 401(k), paid vacation, holidays, and tuition assistance (as applicable).

We are an equal opportunity employer. We evaluate qualified applicants without regard to race, color, religion, sex, national origin, disability, veteran status, and other protected characteristics.

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