Senior Research Associate

Senior Research Associate

About Astellas

Astellas is a global life sciences company committed to turning innovative science into VALUE for patients. We provide transformative therapies in disease areas that include oncology, ophthalmology, urology, immunology and women's health. Through our research and development programs, we are pioneering new healthcare solutions for diseases with high unmet medical need. Learn more at Astellas.com.

Are you driven to make a real difference in the lives of patients?

We're seeking passionate individuals who thrive in dynamic environments, embrace new ideas, and aren't afraid to take intelligent risks. People who act with unwavering integrity and are deeply committed to making a tangible impact.

Purpose & Scope

The Senior Research Associate, Cytogenomics, is responsible for executing advanced molecular workflows, with a significant focus on next-generation sequencing (NGS) applications, including bulk, single-cell, and targeted capture sequencing using Illumina and Oxford Nanopore platforms. The role also supports workflow automation using liquid-handling systems and performs primary human cell culture using rigorous aseptic technique and established culture standards.

Role and Responsibilities

• Execute Advanced NGS Workflows: Perform bulk, single-cell, and targeted-capture sequencing workflows using Illumina and Oxford Nanopore platforms, from sample preparation to library QC and through sequencing run completion.
• Perform Molecular Biology Methods: Execute nucleic acid extraction, quantification, quality assessment, library preparation, target enrichment, amplification, and other high-complexity molecular workflows.
• Support Workflow Development and Optimization: Evaluate, develop, optimize, and troubleshoot molecular and sequencing methods, strategies, and SOPs to improve assay performance, robustness, throughput, and reproducibility.
• Implement Laboratory Automation: Develop, execute, and maintain automated workflows using liquid handling platforms, including method programming, optimization, troubleshooting, and routine operation.
• Perform Primary Human Cell Culture: Culture, maintain, expand, and experimentally manipulate primary human cells using rigorous aseptic technique and established cell-culture standards.
• Analyze and Communicate Experimental Results: Familiarize and adhere to the organizational policy on data integrity. Review experimental and sequencing quality-control data, identify technical issues or trends, document findings, and communicate results clearly to project teams and scientific stakeholders.
• Maintain Laboratory Readiness and Documentation: Maintain accurate experimental records, follow established procedures, support instrument maintenance and laboratory organization, and contribute to the preparation and revision of protocols, methods, and technical reports.