Antibodies, Artificial Intelligence (AI), Biology, Clinical Pharmacology, Clinical Support, Clinical Trial, Colorectal Cancer, Differential Equations, Drug Development, English Language, German Language, Hematology, MATLAB, Machine Learning, Myeloma, Oncology, Pharmacology, Python Programming/Scripting Language, R Programming Language, Scripting (Scripting Languages), Statistical Modeling, Team Player
We are building comprehensive Model-Informed Drug Development (MIDD) capabilities in-house to create reusable platform models across our oncology portfolio. We seek a talented and motivated expert to develop advanced Quantitative Systems Pharmacology (QSP) models in oncology that enable Virtual Population simulations. You will act as a MIDD expert for oncology and integrate this knowledge into Clinical Pharmacology strategy for related development programs.
This means:
- Develop QSP platform models for multiple oncology mechanisms including:
- Immune checkpoint inhibitors (IO/ICI) across colorectal, lung, and ovarian cancers
- Antibody-drug conjugates across lung, ovarian, and colorectal cancers
- T-cell engagers and bispecifics/trispecifics in multiple myeloma
- CAR-T therapies in hematologic malignancies
- Create and optimize Virtual Populations to capture patient heterogeneity and support clinical trial design
- Implement new methods to enhance QSP-driven MIDD, including AI/machine learning augmentation for literature screening, model drafting, and virtual population optimization
- Deliver practical results that inform dose and regimen selection, optimal combinations, therapy duration, and study design for active development programs
- Work as part of a coordinated team under the oversight of a senior pharmacometrician within the PMx Oncology Group
This is how you can make a difference:
- PhD or Master's degree with extensive experience in Quantitative Systems Pharmacology or Systems Biology model development,
- Proven scientific track record and practical experience in several of the following areas
· Statistical modeling
· Modeling with differential equations
· Scripting languages (R, Matlab, Python)
· Drug development
- Critical thinking and self-reflective
- Persistent and resilient
- Ability to connect unrelated concept and to generate original or unique ideas
- Fluency in English required, German would be a plus
EEO:- Mindlance is an Equal Opportunity Employer and does not discriminate in employment on the basis of Minority/Gender/Disability/Religion/LGBTQI/Age/Veterans