Antibodies, Artificial Intelligence (AI), Biology, Clinical Pharmacology, Clinical Support, Clinical Trial, Colorectal Cancer, Differential Equations, Drug Development, English Language, German Language, Hematology, MATLAB, Machine Learning, Myeloma, Oncology, Pharmacology, Python Programming/Scripting Language, R Programming Language, Scripting (Scripting Languages), Statistical Modeling, Team Player
Contract Duration: 24 months
Purpose:
We are building comprehensive Model-Informed Drug Development (MIDD) capabilities in-house to create reusable platform models across our oncology portfolio. We seek a talented and motivated expert to develop advanced Quantitative Systems Pharmacology (QSP) models in oncology that enable Virtual Population simulations. You will act as a MIDD expert for oncology and integrate this knowledge into Clinical Pharmacology strategy for related development programs.
This means:
- Develop QSP platform models for multiple oncology mechanisms including:
- Immune checkpoint inhibitors (IO/ICI) across colorectal, lung, and ovarian cancers
- Antibody-drug conjugates across lung, ovarian, and colorectal cancers
- T-cell engagers and bispecifics/trispecifics in multiple myeloma
- CAR-T therapies in hematologic malignancies
- Create and optimize Virtual Populations to capture patient heterogeneity and support clinical trial design
- Implement new methods to enhance QSP-driven MIDD, including AI/machine learning augmentation for literature screening, model drafting, and virtual population optimization
- Deliver practical results that inform dose and regimen selection, optimal combinations, therapy duration, and study design for active development programs
- Work as part of a coordinated team under the oversight of a senior pharmacometrician within the PMx Oncology Group
This is how you can make a difference:
- PhD or Master's degree with extensive experience in Quantitative Systems Pharmacology or Systems Biology model development,
- Proven scientific track record and practical experience in several of the following areas
- Statistical modeling
- Modeling with differential equations
- Scripting languages (R, Matlab, Python)
- Drug development
- Critical thinking and self-reflective
- Persistent and resilient
- Ability to connect unrelated concept and to generate original or unique ideas
- Fluency in English required, German would be a plus
About US Tech Solutions:
US Tech Solutions is a global staff augmentation firm providing a wide range of talent on-demand and total workforce solutions. To know more about US Tech Solutions, please visit www.ustechsolutions.com.
US Tech Solutions is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.
Internal Id: 26-06120