Senior Scientist, In Vitro ADME

Job Title: Senior Scientist, In Vitro ADME
Location: Emeryville, CA
Duration: 18 months

About the Role:

• We are seeking a highly motivated and collaborative Senior Scientist to support the development and execution of in vitro ADME assays for the evaluation and optimization of potential therapeutic candidates.
• This onsite role, based in Emeryville, CA, will contribute to drug discovery programs by generating high-quality data to inform compound progression and candidate selection.
• The ideal candidate will have hands-on experience conducting in vitro ADME assays in a biopharmaceutical, pharmaceutical, or contract research organization setting, with strong technical expertise in LC-MS/MS, enzyme kinetics, cell-based assays, and data interpretation.

Key Responsibilities:

• Design, develop, and execute in vitro ADME assays to support drug discovery and candidate optimization.
• Conduct ADME screening studies, including but not limited to microsomal stability, hepatocyte stability, permeability, plasma protein binding, and related metabolism assays.
• Generate, analyze, interpret, and report high-quality data to support project decisions and compound progression.
• Collaborate closely with DMPK, biology, chemistry, and project team members to ensure timely delivery of decision-enabling data.
• Design and troubleshoot in vitro experiments to address project-specific questions related to compound metabolism, stability, permeability, and protein binding.
• Contribute to LC-MS/MS bioanalytical method development, sample analysis, assay optimization, and troubleshooting.
• Apply enzyme kinetic and quantitative bioanalytical principles to support assay design and data interpretation.
• Prepare experimental protocols, study summaries, technical reports, and presentations for internal stakeholders and project teams.
• Maintain accurate documentation in electronic laboratory notebooks and ensure adherence to internal quality and safety standards.
• Support implementation and use of laboratory automation platforms, as applicable.

Qualifications:

• BS or MS in chemistry, biochemistry, pharmacology, pharmaceutical sciences, biology, or a related scientific discipline.
• Minimum of 2 years of relevant hands-on in vitro ADME experience in a biopharmaceutical, pharmaceutical, or contract research organization environment.
• Strong understanding of DMPK and ADME principles, including assay design, data analysis, and interpretation.
• Demonstrated experience designing and executing automated in vitro assays to evaluate and optimize ADME properties of drug candidates.
• Hands-on experience with LC-MS/MS-based sample analysis; experience with Sciex instruments is preferred.
• Proficiency with data analysis and visualization tools such as Microsoft Excel, GraphPad Prism, Analyst, or similar software.
• Experience using electronic laboratory notebooks.
• Experience with laboratory automation platforms such as Hamilton, Tecan, or similar systems is preferred.
• Strong organizational skills with the ability to manage multiple priorities in a fast-paced, collaborative research environment.
• Excellent verbal and written communication skills, with the ability to present scientific findings clearly to cross-functional teams.
• Demonstrated ability to work independently while contributing effectively in a team-oriented setting.

• Note:
  The successful candidate is expected to maintain a safe laboratory environment and follow all applicable environmental, health, and safety (EHS) policies and procedures.
• The role requires appropriate handling of chemicals, biological materials, and laboratory instrumentation, including the use of required personal protective equipment (PPE).
• The candidate should demonstrate a strong commitment to safe laboratory practices.