Senior Scientist, Protein Engineering & Structural Biology

Gables Search Group

Rockville, MD

JOB DETAILS
LOCATION
Rockville, MD
POSTED
8 days ago

Our biotech client is expanding their world-class Antibody Engineering group and seeking an exceptional scientist with deep expertise in structural biology and protein engineering, with a strong drive to apply structural insight to antibody discovery and optimization.

The ideal candidate will take on the following tasks:

· Leverage cryo-EM, X-ray crystallography, and complementary biophysical techniques to elucidate antibody-antigen interactions, define epitope architecture, and inform structure-guided engineering decisions.
· Apply protein structure/function expertise to challenging drug targets — including membrane proteins and conformational epitopes — translating structural knowledge into actionable engineering hypotheses.
· Partner closely with antibody engineering colleagues to integrate structural data into discovery and optimization campaigns, driving rational lead progression.
· Develop and advance computational and experimental approaches to protein structure prediction, model validation, and structure-based design, including integration of AlphaFold, Rosetta, and molecular dynamics tools.
· Shape intellectual property and advance the field through inventorship and high-impact publications.
· Contribute broad, adaptable skill sets across the antibody engineering platform — bringing a generalist scientific rigor that accelerates innovation beyond any single technical discipline.

The ideal candidate will possess the following qualifications:

· PhD in Structural Biology, Biophysics, Biochemistry, or related field.
· Deep hands-on expertise in cryo-EM and/or X-ray crystallography, with demonstrated application to protein structure/function questions.
· Prior exposure to antibody-based work is a plus but not required — broad scientific adaptability is valued over narrow specialization.
· High-impact publication record preferred.
· Desire to work at the interface of experimental structural biology and antibody development.

About the Company

G

Gables Search Group

Gables Search Group headquartered in Cleveland, Ohio has been a leader in search and placement nationwide since 2002.  Our company specializes in both direct and contract (temporary) staffing in all industries and disciplines.

At Gables Search Group, we connect exceptional professionals with outstanding organizations.  Our commitment to integrity, excellence, partnership, innovation, and respect sets us apart. With a personalized approach to recruitment, we ensure the perfect match between candidates and employers.

Whether you are a talented professional seeking new opportunities or an organization looking to build a high-performing team, Gables Search Group is here to guide you through the journey. Our success is built on the success of our clients and candidates, and we are dedicated to making a positive impact on the careers and businesses we serve.

COMPANY SIZE
50 to 99 employees
INDUSTRY
Staffing/Employment Agencies
FOUNDED
2002
WEBSITE
https://www.gablessearch.com/