Job ID
REQ-10079709
Jul 10, 2026
USA
Available in: English
Summary
Come help us discover innovative therapeutic breakthroughs for patients! We are seeking a passionate, curious, and collaborative protein scientist to join our Protein Sciences group, an interdisciplinary team that has expertise in protein chemistry, enzymology, biophysics, NMR, X-ray crystallography, and electron microscopy.As a Protein Scientist, you will focus primarily on the production of proteins to enable structure-guided drug discovery for multiple disease areas. Your responsibilities will include designing protein constructs, carrying out expression in various cell systems, developing methodologies for purification, and protein characterization using biophysical and structural techniques. You will closely collaborate with colleagues within our group and across disease areas to tackle challenging drug discovery projects, contributing to the advancement of early-stage drug development.
About the Role
Internal Job Title: Senior Scientist I/IILocation: onsite, San Diego, CAAbout the role:Come help us discover innovative therapeutic breakthroughs for patients! We are seeking a passionate, curious, and collaborative protein scientist to join our Protein Sciences group, an interdisciplinary team that has expertise in protein chemistry, enzymology, biophysics, NMR, X-ray crystallography, and electron microscopy.As a Protein Scientist, you will focus primarily on the production of proteins to enable structure-guided drug discovery for multiple disease areas. Your responsibilities will include designing protein constructs, carrying out expression in various cell systems, developing methodologies for purification, and protein characterization using biophysical and structural techniques. You will closely collaborate with colleagues within our group and across disease areas to tackle challenging drug discovery projects, contributing to the advancement of early-stage drug development.Key Responsibilities:Develop and execute protocols to generate high-quality protein reagents for small molecule screening, hit validation, and structural biology studies of protein-small molecule complexes.Design protein constructs based on literature and AI-based structure prediction tools.Express protein expression in mammalian and insect cell systems.Purify protein purification using various chromatography techniques and FPLC equipment.Collaborate with colleagues to characterize protein-protein and protein-ligand interactions using biophysical and structural biology techniques.Apply critical thinking to troubleshoot experiments and design new approaches.Maintain a high level of professional expertise through familiarity with scientific literature and accurate and detailed record keeping.Work both independently and collaboratively as part of multidisciplinary teams.Present and communicate results with protein science colleagues and project teams. Essential Requirements:BS/MS degree in biochemistry, life sciences, molecular biology or related field with at least 5+ years of relevant research laboratory experience.Proven in-depth knowledge with hands-on experience in recombinant protein construct design and expression, including insect cell and mammalian expression systems.Proficiency in different protein purification techniques such as affinity, ion exchange, and gel filtration chromatography using FPLC or HPLC systems.Understanding of protein characterization as well as protein-ligand interactions using biophysical methods (e.g., SPR, DSF, ITC, LC/MS).Demonstrated critical thinking and troubleshooting ability when handling challenging proteins such as aggregated proteins, multicomponent complexes, or membrane proteins.Passionate about biomedical research and drug discovery. Motivated to learn new techniques in protein biochemistry, biophysics, and structural biology.Excellent communication skills, both oral and written, and ability to work effectively in a matrix team environment.Desirable Requirements:Experience in protein crystallography, bio-NMR, or cryo-EM, either directly or working closely with others.Experience in biophysical methods to characterize protein-protein or protein-ligand interactions.Compensation and Benefits:The salary for this position is expected to range between $93,800 and $174,200 per year for Senior Scientist I, and $98,700 and $183,300 for Senior Scientist II. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.To learn more about the culture, rewards and benefits we offer our people click here.
Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients' lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-cultureBenefits and Rewards: Learn about all the ways we'll help you thrive personally and professionally.Read our handbook (PDF 30 MB)
EEO Statement:The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.Accessibility & Reasonable AccommodationsThe Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [email protected] or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
Division
Biomedical Research
Business Unit
Research
Location
USA
State
California
Site
San Diego
Company / Legal Entity
U175 (FCRS = US175) Novartis Institutes for BioMedical Research, Inc.
Functional Area
Research & Development
Job Type
Full time
Employment Type
Regular
Shift Work
No
Research & Development Biomedical Research USA
Job ID
REQ-10079709
Senior Scientist, Protein Production
Apply to Job
Job ID
REQ-10079709
Senior Scientist, Protein Production
Apply to Job
Novartis provides healthcare solutions that improve and extend people’s lives. We use science-based innovation to address some of society’s most challenging healthcare issues. We discover and develop breakthrough treatments and find new ways to deliver them to as many people as possible. Our company is focused on industry-leading divisions with innovation power and global scale: pharmaceuticals, eye care and generic medicines Novartis is headquartered in Basel, Switzerland. Novartis Group companies employ approximately 120,000 associates and its products are available in more than 180 countries around the world.