Senior Scientist, Toxicology

Senior Scientist, Toxicology

COMPANY OVERVIEW

AIRNA is a biotechnology company with a mission to be the leading RNA editing company delivering precision therapies to patients with rare and common diseases.

AIRNA is harnessing advances in genetics to develop transformative RNA-editing medicines that improve human health. Our proprietary platform is based on groundbreaking research by pioneers of the field and company co-founders Thorsten Stafforst (University of Tübingen) and Jin Billy Li (Stanford University) and enables optimal potency, safety, and delivery. AIRNA is advancing a robust pipeline of therapeutic candidates that are designed to provide functional cures for severe or chronic diseases by repairing harmful genetic variants or introducing beneficial variants promote optimal health.

AIRNA has raised $245 million in financing from a world-class syndicate of investors including Arch Venture Partners, Forbion, Venrock Healthcare Capital Partners, RTW Investments, Nextech Invest, and ND Capital. We value teamwork, resilience, excellence, human, and health, and have a diverse team at both our headquarters in Cambridge, MA and our research operations in Tübingen, Germany.

JOB DESCRIPTION:

AIRNA is seeking a highly motivated Senior Scientist in Toxicology to help drive the pre-clinical safety strategy for the successful development of oligonucleotide programs across all stages of development. Reporting to the Head of Preclinical Development, this role will provide scientific leadership in toxicology and safety pharmacology across discovery and development project teams. Working cross-functionally, the Senior Scientist will apply deep toxicology expertise to inform decision-making across the drug development value chain. The individual will serve as Study Director, leading toxicology study operations and coordinating internal and external teams to ensure high-quality, timely execution.

This position is based in Cambridge, MA.

RESPONSIBILITIES

• Study Director for non-GLP /GLP toxicology studies in rodent and non-rodents.
• Managing CRO's, protocol development and study execution.
• Serve as an SME related to nonclinical safety issues.
• Prepare and review of written safety pharmacology and toxicology reports; and the authoring of the nonclinical document sections for regulatory submissions.

QUALIFICATIONS

• PhD degree in toxicology, pharmacology or related disciplines with a minimum of 3 yrs of relevant industry experience.
• BS/MS degree and DABT (preferred) with 10 years of relevant experience.
• Experience with non-clinical development programs for antisense oligonucleotides or siRNA.
• Knowledgeable about GLP policies and/or regulatory nonclinical testing requirements for pharmaceutical development.
• In depth familiarity with ICH, FDA and other regulatory guidance and regulations relevant to non-clinical research.
• Experience managing CROs driving GLP/non-GLP studies serving as a Study director.
• Excellent written and oral communication, interpersonal, and organizational skills.
• Initiative in producing high quality work products in a start-up environment.

LOCATION:

Hybrid - 3 days a week in Cambridge, MA

SALARY:

$140-160k plus bonus and equity