Be the strategic leader providing a strong, clear voice for clinical programs. Develop creative but realistic approaches to drug development and lead clinical efforts to secure first-in-human and proof-of-concept milestones. Oversight of trial conduct and safety. Serve as early clinical research lead on ePT (Early Project Team) or chair of CDST (Clinical Development Sub-Team) depending on the stages of programs, with accountability for the Clinical Development Plan. Provide strategic consultation and guidance to Research on all decisions that have significant clinical components and implications. Collaborate closely with Preclinical, Translational Research, Regulatory Affairs and Medical Affairs to ensure tight strategic integration of product development plans. Be accountable via Clinical Research and Clinical Operations for all relevant timelines and deliverables. Contribute to and/or closely supervise (as relevant) all major written deliverables (protocols, IBs, informed consent forms, briefing documents, regulatory submissions, original articles, abstracts) and presentation materials. Managerial responsibility with direct report(s) of Medical Director. Influence internal and external audiences in a high impact, highly visible fashion. A highly driven, dynamic, engaged and accomplished physician-scientist with experience and insight will thrive in this role. MD or MD PhD, Board Certification (or equivalent) or specialist training in Nephrology is preferred 5+ years industry experience with early phase clinical program leadership experience in CVM or renal drug development, including leading trial design and execution and successful regulatory interactions Ability to develop state-of-the-art CDPs and to navigate through internal governance boards in securing strategic approval of CDPs as well as resource planning and assignment Experience in effectively leading x-EA global clinical team (or CDST equivalent), managing direct reports with strong mentorship, and exhibiting effective collaborations with other EAs to fulfill program goals and objectives Sound scientific and clinical judgment LI-JB1 #LI-Hybrid U.S. Pay Range $259,300.00 - $350,800.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers