Sr. Software Engineer

About Prenosis

Prenosis Inc. is an artificial intelligence company pioneering precision medicine in acute care. Our Immunix precision medicine platform drives the development of precision products and enables real-time delivery of optimal therapy. We've created and validated the first FDA-authorized AI biomarker for sepsis, the Sepsis ImmunoScore®.

At Prenosis, we:

• Put patients first

• Disrupt with evidence

• Excel with integrity

• Go far together

Our staff collectively defined these corporate values to demonstrate how our teams contribute to meaningful and authentic change in U.S. healthcare. We value our diverse talent, strive to foster a culture of continuous learning, and aim to maintain a feeling of belonging and shared sense of purpose.

Prenosis is headquartered in Chicago Illinois and generally operates on Central Time Zone.

Position Summary

We are looking for a hands-on Senior Software/SRE Engineer who spends the majority of their time writing and reviewing production code. You will be a primary technical contributor on the team, designing systems, closing pull requests, debugging production incidents, and setting the technical bar through example. Roughly 80% of your time will be spent on individual technical contribution and architecture; the remaining 20% on the functional management responsibilities that keep a small, high-performing team running smoothly.

You will work across our Go backend services, Python APIs, TypeScript frontend, and Kubernetes infrastructure. Owning full-stack delivery in a HIPAA-regulated environment where correctness and reliability are non-negotiable.

Responsibilities

• Write production-quality Go and Python backend services: APIs, data pipelines, business logic, and integrations.

• Build and maintain TypeScript/React frontend features with real attention to UI quality and client-side performance.

• Conduct deep, substantive code reviews that raise the technical quality of the entire codebase.

• Drive architectural decision records (ADRs) and hands-on prototypes to validate technical direction before committing the team.

• Champion HIPAA compliance and security best practices at the code level - in data handling, auth, encryption, and audit logging.

• Ensure the availability and reliability of applications and systems; proactively identify and address potential failure points before they affect patient-facing workflows.

• Implement and manage comprehensive monitoring, logging, and alerting using Prometheus, Kibana, the Elastic Stack, OpenTelemetry, or equivalent tools.

• Partner with other developers to design, implement, and maintain CI/CD pipelines (GitHub Actions, GitLab, or equivalent) that streamline development workflows and deployment safety.

• Drive SDLC improvements: branch strategies, automated testing gates, progressive delivery, and rollback procedures.

• Embed security and compliance checks into pipelines so HIPAA controls are verified automatically, not manually.

• Maintain cloud infrastructure on AWS and GCP - ensuring scalability, high availability, and cost efficiency.

• Manage infrastructure as code using Terraform/Terragrunt; maintain clean, version-controlled, peer-reviewed infrastructure changes.

• Manage Kubernetes clusters across AWS (EKS) and GCP (GKE); tune resource limits, manage rollouts, and operate services at scale.

• Implement and maintain deployment tooling - Helm, Kustomize, ArgoCD, Flux - to optimize workload management and enable GitOps workflows.

• Debug misbehaving workloads, manage cluster upgrades, and drive operational maturity across the platform.

Expected frequency and duration of travel: 2-3 times a year

Qualifications and Experience

Required:

• 7+ years of software engineering experience with a consistent record of hands-on technical contribution.

• Expert-level Go and/or Python backend development; you write idiomatic, production-grade code daily.

• Strong coding skills in Python and similar languages for automation, tooling, and operational scripting.

• Working knowledge of Kubernetes (EKS, GKE): debugging workloads, tuning resource limits, and managing rollouts. (Helm, Kustomize, ArgoCD, or Flux a plus.)

• Production TypeScript/React frontend experience - real client-side UI work, not just Node.js services

• Hands-on AWS and GCP experience: maintaining and debugging managed services, networking, and IAM; deploying and operating containerized workloads across both platforms in production.

• Experience with monitoring and observability tools: Prometheus, Elastic Cloud (or equivalent).

• Hands-on CI/CD experience with GitHub Actions, GitLab.

• Hands-on Terraform/Terragrunt experience: maintaining and extending existing infrastructure as code.

• Strong PostgreSQL skills: schema design, complex query optimization, indexing, partitioning, and migration management.

• Experience building in a regulated or high-stakes environment where data privacy and auditability matter

• Analytical problem-solver: you debug and resolve complex, cross-system issues without losing the thread from UI to database to infrastructure.

What We Offer

• Comprehensive Medical, dental, and vision coverage

• 401(k) with company match

• Unlimited time off

• Major opportunity for career development to make significant impact at an exciting growth-stage company

• Collaborative and innovative work environment

• Chance to make a real impact on patient care

• Opportunity to work on cutting-edge AI technology in healthcare

Salary range: $120,000 -$150,000 per year

Prenosis is an Equal Opportunity Employer

Must be eligible to work in the US without sponsorship