Overview
Pipeline Delivery Systems & Process Enablement is a strategic leadership role responsible for building and scaling a seamless integrated ecosystem of systems data and operational processes that enable efficient and predictable delivery of Alnylams development pipeline. This leader will drive operational excellence across Clinical Operations Data Management and Program Management ensuring that systems and processes are standardized user-centric and enable real-time data-driven decision-making. Through strong leadership in process design training and change management this role ensures consistent adoption and sustained performance accelerating the delivery of RNAi therapeutics to patients.
Key Responsibilities
Systems & Digital Enablement Strategy
Define and execute the Pipeline Delivery systems and data strategy aligned to R&D priorities and the future‑state operating model including oversight of integrated clinical and operational platforms.
Partner with IT and Digital to deliver scalable user‑centric solutions and a single source of truth enabling speed quality transparency and informed program and portfolio decision‑making.
Process Excellence & Standardization
Design implement and continuously improve end-to-end processes across study start-up execution data flow and reporting ensuring processes are aligned with regulatory requirements and inspection readiness expectations.
Drive standardization of workflows templates and best practices across Pipeline Delivery functions simplifying complexity by eliminating redundant or low-value processes.
Operational Performance & Continuous Improvement
Partner with Portfolio Management to establish a performance management framework KPIs metrics dashboards to monitor process effectiveness and system utilization.
Identify and address operational bottlenecks inefficiencies and variability.
Lead continuous improvement initiatives to enhance cycle times data quality and execution predictability.
Embed a culture of operational discipline and continuous learning.
Training & Capability Building
Develop and implement a comprehensive training strategy aligned to systems processes and ways of working.
Ensure role-based training enables teams to operate effectively within the Pipeline Delivery model.
Build capability in data literacy system utilization and process adherence.
Continuously evaluate and evolve training approaches to drive effectiveness and engagement.
Change Management & Adoption
Lead enterprise change management to drive adoption of new systems processes and operating models using structured approaches to stakeholder engagement communication and behavior change.
Champion user experience and organizational readiness ensuring changes are implemented with minimal disruption and sustained adoption over time.
Cross-Functional Integration
Serve as a key integrator across Clinical Operations Data Management Program Management and broader R&D functions and partner closely with Portfolio Management to ensure systems support planning governance and performance tracking.
Ensure systems and processes enable seamless handoffs clear ownership and aligned execution.
Align with Vendor & Alliance Management to ensure external partners operate within defined systems and processes.
Organizational Leadership
Build and lead a high-performing Systems & Process Enablement organization fostering a a culture of innovation accountability and continuous improvement.
Define roles capabilities and structure required to support a scalable Pipeline Delivery model.
Develop talent and ensure strong succession planning.
Key Success Metrics
Enterprise adoption and impact Effective utilization of systems and standardized processes across Pipeline Delivery driving compliance improved data quality and faster more informed decision‑making.
Operational performance and transformation success Reduced cycle times and inefficiencies through strong training effectiveness user proficiency and successful delivery and sustained adoption of transformation initiatives.
Qualifications
BSMS in Life Sciences Engineering Information Systems Business or a related field.
20 years of experience in biotechpharma with leadership roles in clinical systems operations process excellence or digital enablement.
Demonstrated experience operating at the enterprise or portfolio level supporting complex multi program clinical pipelines.
Proven track record implementing enterprise systems and process transformations in R&D or Clinical Development e.g. CTMS eTMF data platforms reporting and analytics.
Experience driving large-scale change management and adoption initiatives.
Experience partnering closely with IT Digital and Data organizations to deliver scalable user‑centric solutions.
Expertise establishing performance management frameworks including KPIs dashboards and operational metrics to support portfolio and program decision‑making.
Strong continuous improvement mindset with experience leading initiatives that improve cycle times data quality and execution predictability.
Strong understanding of clinical development processes data flows and regulatory requirements.
Strong capability in organizational change management including stakeholder engagement communication planning and adoption measurement.
U.S. Pay Range
301800.00 - 408200.00
The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including but not limited to relevant experience skills and education. This role is eligible for an annual short-term incentive award e.g. bonus or sales incentive and an annual long-term incentive award e.g. equity.
Alnylams robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical dental and vision coverage life and disability insurance a lifestyle reimbursement program flexible spending and health savings accounts and a 401kwith a generous company match. Eligible employees enjoy paid time off wellness days holidays and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.
Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website httpswww.alnylam.comcareers
About Alnylam
We are the leader in RNAi therapeutics - a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of whats possible. Our deep pipeline late-stage programs and bold vision reflect our core values fierce innovation passion for excellence purposeful urgency open culture and commitment to people. Were proud to be a globally recognized top employer where an authentic inclusive culture and breakthrough thinking fuel one another.
At Alnylam we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex gender or gender identity sexual orientation race color ethnicity national origin ancestry citizenship religion creed physical or mental disability pregnancy status or related conditions genetic information veteran or military status marital or familial status political affiliation age or any other factor protected by federal state or local law. Alnylam is an E-Verify Employer.