PRINCIPAL R&D/PRODUCT DVL ENGINEER(SA) TE Connectivity plcPRINCIPAL R&D/PRODUCT DVL ENGINEER(SA)Marlborough, MADrive thought leadership by educating and influencing internal and external stakeholders, from executives and product teams to key decision-makers in customer organizations, on emerging industry trends, TE's technical capabilities, and high-value engineering solutions. Serve as the primary technical liaison for TE's customers, actively engaging with hyperscalers, OEMs, and system architects to gain deep insights into next-generation compute, AI, storage, and networking challenges.
Principal Scientist, Clinical Research - Immunology/Dermatology Merck & Co IncPrincipal Scientist, Clinical Research - Immunology/DermatologyBoston, MA$255,800–$402,700 / yearAssist the Senior Director, Associate Vice-President/Vice-President and Product Development Team Lead in ensuring that appropriate corporate personnel is informed of the progress of studies of our company and competitors' drugs and internal and external expert opinion on scientific questions relevant to their areas of responsibility. With a focus on late-stage development, the Clinical Director will manage the entire cycle of clinical development, including determination of appropriate disease indications to pursue and subsequent study design, initiation, execution, monitoring, analysis, regulatory filing, and publication.
Principal Systems Engineer Torch Technologies IncPrincipal Systems EngineerMA$140,000–$160,000 / yearCommand, Control, Communications, and Battle Management (C3BM) has been tasked with delivering an integrated Department of the Air Force (DAF) Battle Network providing resilient decision advantage and enabling the USAF, USSF, Joint, and Coalition Force to win against the pacing challenge. The MIT is responsible for translating operational requirements into technical solutions, developing integrated architectures, assessing risks, supporting acquisition execution strategies, and coordinating test and evaluation activities to ensure capabilities are delivered to operational users.
Sr. Principal Scientist (Sr. Director) - Regulatory Liaison Merck & Co IncSr. Principal Scientist (Sr. Director) - Regulatory LiaisonBoston, MA$190,800–$300,300 / yearRequired Skills: Biological Sciences, Clinical Reporting, Drug Development, Global Health, In Vitro Diagnostics (IVD), Multiple Therapeutic Areas, Pharmaceutical Regulatory Affairs, Process Improvements, Product Approvals, Regulatory Affairs Compliance, Regulatory Affairs Management, Regulatory Communications, Regulatory Compliance, Regulatory Issues, Regulatory Strategies, Regulatory Strategy Development, Written Communication. As the Global Regulatory Lead (GRL), the Senior Principal Scientist functions as the regulatory single, accountable, global point of contact on the project team and interacts with the global regulatory agencies and/or subsidiaries with regard to global regulatory strategy/registration requirements for one or more company investigational and marketed drugs/biologics in early- and/or late-stage development.
Principal Scientist, Systems and Disease Biology SanofiPrincipal Scientist, Systems and Disease BiologyCambridge, MA$122.25–$176.58 / hourD. in systems biology, computational biology, biostatistics, or related quantitative field with proven experience in a relevant disease area (Immunology, Neurology or Oncology) OR PhD in biological sciences, biomedical sciences, immunology, neuroscience, oncology or in a related disease area and proven advanced track record of data analytics, ML/AI, or computational biology. Leading projects involving internal experiment design and data analytics as well as outsourcing of established workflows and/or complex follow-up mechanistic assays (organoid, CRISPR, proteomics).
Principal Commercial Data Architect MGM Resorts InternationalPrincipal Commercial Data ArchitectMA$122,700–$163,600 / yearTHE DAY-TO-DAY: Define and execute a multi-year Marketing and Revenue Management data architecture roadmap aligned to commercial strategy, including lakehouse evolution, interoperability, governance, and observability. You will partner closely with executive leadership, commercial stakeholders, and technology teams to ensure our data platforms are resilient, governed, and built for the future.
Principal Data Scientist - Gen AI Xometry IncPrincipal Data Scientist - Gen AIWaltham, MA$200,000–$230,000 / yearIn this role, you will serve as a technical leader, owning a 12 month technical roadmap, driving large-scale cross-functional ML and AI initiatives, and setting the long-term scientific direction for AI-driven solutions that enhance Xometry''s service offerings. Generative AI Development: Develop and deploy generative AI models and large language models (LLMs) for multimodal document processing, focusing on extracting structured data from technical drawings, purchasing orders, and other complex documents.
Principal Embedded Software Engineer Lexington Medical, Inc.Principal Embedded Software EngineerBedford, MA$180,000–$220,000 / yearThe embedded software operates under tight real-time, safety-critical constraints, directly driving electromechanical subsystems where milliseconds and failure modes matter, and you will be in the lab working through hardware-software integration issues alongside electrical and mechanical engineers, not just reviewing designs from a distance. This is a hands-on role: you will be building the embedded software for our surgical stapling platform yourself, writing code, integrating drivers, and debugging at the hardware level, while also owning the technical architecture and setting the long-term direction for embedded systems across the platform.
NewPrincipal Product Designer MoonpigPrincipal Product DesignerManchester, NHWe’re proud to have a number of employee-led groups driving this forward, including our LGBTQ+, Gender Balance, Neurodiversity and EMBRACE (Educating Myself for Better Racial Awareness and Cultural Enrichment) communities, plus our Group-wide EDI committee. Wellbeing First: Private healthcare (UK) and mental health support ️ Flexible Working & Time Off: Generous holidays, hybrid working (1-3 days in office, depending on role/team) & up to 20 days of international working.
Sr Principal Program Protection Software Engineer RTX CorpSr Principal Program Protection Software EngineerWoburn, MAAs part of our commitment to maintaining a secure hiring process, candidates may be asked to attend select steps of the interview process in-person at one of our office locations, regardless of whether the role is designated as on-site, hybrid or remote. At RTX, the world largest aerospace and defense company, 185,000 great minds are united by purpose and inspired to make a difference solving the world's most complex problems.
Principal Systems Engineer - Flight Mission Simulation Lead, Onsite RTX CorpPrincipal Systems Engineer - Flight Mission Simulation Lead, OnsiteAndover, MAThe Systems Engineering & Test Capabilities team is seeking a highly motivated Principal Systems Engineer to lead technical simulation operations and maintenance support for the Flight Mission Simulator (FMS) used in Patriot test programs. Serve as a subject matter expert for root-cause identification and resolution of system anomalies, system performance assessments, and cross-functional engineering coordination to support overall system capability development and checkout.
Learning Assistant (2026-27 SY) Weston Public SchoolsLearning Assistant (2026-27 SY)Weston, MAThe school district includes a high school for grades 9-12, a middle school for grades 6-8, an upper elementary school for grades 4-5, and two lower elementary schools for pre-kindergarten through grade 3. Since 1967, Weston has participated in METCO (Metropolitan Council for Educational Opportunity) - a voluntary school integration program that places Boston residents in suburban schools. Position Overview Weston is seeking to hire a Learning Assistant to provide academic, social, and behavioral support to students in collaboration with the classroom teachers at Country Elementary School.
Learning Assistant Weston Public SchoolsLearning AssistantWeston, MAThe school district includes a high school for grades 9-12, a middle school for grades 6-8, an upper elementary school for grades 4-5, and two lower elementary schools for pre-kindergarten through grade 3. Since 1967, Weston has participated in METCO (Metropolitan Council for Educational Opportunity) - a voluntary school integration program that places Boston residents in suburban schools. Position Overview Weston is seeking to hire a Learning Assistant to provide academic, social, and behavioral support to students in collaboration with the classroom teachers at Field Elementary School.
Principal Product Designer Chegg, Inc.Principal Product DesignerBoston, MassachusettsWe need someone who operates at the intersection of product strategy, design craft, and AI-first delivery: a person who can determine which problems are worth solving, turn that into a plan the team can build, and bring it to life through design, rapid prototyping, and real user testing. Use a variety of techniques (one-on-one user interviews, rapid prototypes built with AI coding tools, and whatever else works) to validate and invalidate a wide breadth of ideas quickly and cheaply.
Principal Scientist, Lab Platform Disruptive Technologies Merck & Co IncPrincipal Scientist, Lab Platform Disruptive TechnologiesCambridge, MA$194,100–$305,600 / yearRequired Skills: Antibody Drug Conjugates (ADC), Biodesign, Detail-Oriented, Emerging Technologies, Ethical Compliance, Gene Cloning, Gene Expression Analysis, Immunochemistry, Leadership Engagement, Mass Spectrometry Analysis, Microscopy Techniques, Project Leadership, Protein Engineering, Protein Interactions, Protein Purifications. This individual will identify and translate emerging, literature-supported technologies into scalable internal capabilities, with a focus on multiplying both the scale and speed of quantitative data generation (e.g., binding measurements) to advance therapeutic programs via GenAI/ML-driven discovery and iterative design-make-test cycles.
Principal Software Engineer Cadence Design Systems IncPrincipal Software EngineerBurlington, MA$117,600–$218,400 / yearDevelop Software solutions that are efficient in time and memory complexity • Analyze and improve existing algorithms • Collaborate with Senior architects on next generation architectural projects • Participate in code reviews, design discussions, and performance benchmarking • Document solutions with functional and design specifications • Write tests to rigorously test the developed code. Strong software engineering and problem solving skills Deep understanding of data structures, algorithms, and databases Understanding of compilers, parsing and code generation, static elaboration, event driven or parallel simulation.
Principal Software Engineer Red Hat Inc.Principal Software EngineerBoston, MARemote$193,390–$318,980 / yearDevelop and implement end-to-end automation frameworks for the testing and validation of the DPF Operator on OpenShift, ensuring robust performance and reliability in complex, multi-node cluster environments, and conduct performance analysis and benchmarking of DPU-offloaded networking to validate and document high-throughput and low-latency capabilities. Develop and enhance image-based OpenShift installation processes, enabling rapid, scalable, and repeatable deployments of pre-configured and validated Single Node OpenShift instances for edge and remote locations.
Principal Software Engineer DigitalOceanPrincipal Software EngineerBoston, MARemote$235,200–$294,000 / yearIAM and KMS are the bedrock of trust at DigitalOcean; our services sit in the critical path of every request, authorizing billions of transactions per second with single-digit millisecond latency, and securing the cryptographic material that protects every customer workload on the platform. Evolve Key Management: Design and deliver a robust, multi-tenant KMS, including envelope encryption, customer-managed key patterns, and HSM-backed key material, that gives customers deep, fine-grained control over their data security posture.
Principal Product Manager - Hardware Accelerator Virtualization Red HatPrincipal Product Manager - Hardware Accelerator VirtualizationBoston, MassachusettsRemoteMust have two (2) years of experience with: Red Hat OpenShift Platform, Red Hat OpenStack Platform, VMware vSphere, or other enterprise-level infrastructure solutions; the Agile development process; overseeing the integration and lifecycle management of hardware enablement components at the kernel-level, driver compatibility, and upgrades; and management frameworks for various types of accelerators. Master’s degree (U.S. or foreign equivalent) in Mechanical Engineering, Technology Management, Business Administration or related field and five (5) years of experience in the job offered or related role OR Bachelor's degree (U.S. or foreign equivalent) in Mechanical Engineering, Technology Management, Business Administration or related field and seven (7) years of experience in the job offered or related role.
Principal Scientist, Process Development (Expression Systems) ModernaTXPrincipal Scientist, Process Development (Expression Systems)Norwood, MassachusettsWe are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. PhD in Molecular Biology, Microbiology, Chemical/Biochemical Engineering, Biotechnology, Synthetic Biology, or a related discipline with 5+ years of relevant industry experience; or MS with 10+ years; or BS with 12+ years of relevant industry experience.