Principal Product Manager - EAMC ImprivataPrincipal Product Manager - EAMCWaltham, MA$180,600–$191,100 / yearAt Imprivata, we deliver unified access and security management programs that eliminate friction, empowering healthcare and mission-critical organizations to work smarter, faster, and more securely. The Principal Product Manager is responsible for Imprivata's Enterprise Access Management Cloud offering and the overall success of that business area, including adoption and growth.
Principal Product Manager Museum of SciencePrincipal Product ManagerBoston, Massachusetts$88,000–$110,000 / yearCollaboration and Communication: Effectively translates product strategy into clear, actionable plans and communicates progress, trade-offs, and outcomes to both technical and non-technical audiences, including senior leadership. Define and drive the product strategy for key digital platforms, including the Museum’s website and audience-facing experiences, ensuring alignment with organizational priorities and measurable outcomes.
Principal Thermal Mechanical Engineer FlexPrincipal Thermal Mechanical EngineerLittleton, MA$153,500–$211,000 / yearWhat a typical day looks like: Lead the initial design, analysis, and optimization of complex fluid systems from concept initial CAD to final detailed CAD and drawing for liquid cooling, including cold plates, pumps, fluids, tubing, and heat exchangers, for the latest computer processing chipsets. The Principal Mechanical Engineer will provide technical leadership, mentorship, and hands-on expertise in mechanical design, fluid dynamics, and heat transfer but also work closely with customers in communicating the art of the possible with JetCool technology and building a strong customer relationship on a technical level.
Principal Noise Consultant AcentechPrincipal Noise ConsultantCambridge, MA$115,000–$145,000 / yearAcentech, a multidisciplinary design consulting firm specializing in acoustics, vibration, audiovisual systems, IT and security system design seeks to hire a senior- to principal-level consultant to work with our Noise and Vibration team. We foster a collaborative environment of diverse talent, and encourage people of color, lesbian, gay, bisexual, transgender, queer and non-binary people, neurodivergent, veterans, parents, and individuals with disabilities to apply.
Principal Engineer, Core Infrastructure KlaviyoPrincipal Engineer, Core InfrastructureBoston, MA$244,000–$366,000 / yearIn addition to base salary, our total compensation package may include participation in the company's annual cash bonus plan, variable compensation (OTE) for sales and customer success roles, equity, sign-on payments, and a comprehensive range of health, welfare, and wellbeing benefits based on eligibility. AI‑enabled platform: Approved AI tooling is integrated into IDE/CI/CD with repo policies and auditability; 70% MAU among eligible engineers; MTTR down 20-30% via AI‑assisted triage; flaky‑test rate decreases through targeted, AI‑suggested fixes.
Principal Program Scheduler Torch TechnologiesPrincipal Program SchedulerHanscom AFB, Massachusetts$145,000–$160,000 / yearBy enabling aircrews to electronically receive and process tasking orders, intelligence inputs, target coordinates, and mission‑critical flight and weapons data, MPS enhances combat effectiveness, increases sortie generation rates, and improves aircrew readiness and survivability across the Combat Air Forces (CAF) and Mobility Air Forces (MAF). Several factors can influence the salary for a position including but not limited to, Federal Government contract labor categories and contract wage rates, geographic location, business considerations, scope and responsibilities of the position, local or other applicable market conditions, and internal equity.
Principal Application Scientist Revvity, Inc.Principal Application ScientistHopkinton, MA$120,000–$155,000 / yearWorking with key commercial entities, you will craft automation methods & workflows that will be disseminated globally, allowing Revvity specialist to support internal sales specialists and customers with novel and well annotated automation methods, allowing Revvity to continue to lead the field. The individual is expected to support the global Revvity automation business by expanding instrument capabilities, working as necessary with technical support to troubleshoot complex customer issues, and providing training and marketing material for new application capabilities that will be used to support the sales of automation instruments globally.
Principal Engineer - Security Products, Security Visibility DigitalOceanPrincipal Engineer - Security Products, Security VisibilityBoston, MARemote$235,200–$294,000 / yearEvolve the Audit Logging Platform: Lead the redesign of DigitalOcean's audit log infrastructure to support immutable, tamper-evident, compliance-grade event records with fine-grained retention controls, cross-account federation, and real-time streaming access for customers and internal security teams. Core Experience: You possess over 10 years of software engineering expertise, including 4+ years dedicated to audit logging, security telemetry, SIEM integration, or managing high-throughput data pipelines within cloud or IaaS ecosystems.
Principal Software Engineer Boston Human Capital PartnersPrincipal Software EngineerBoston, MassachusettsRemoteThis role centers on building high-performance distributed systems, powering data-intensive services, and enabling seamless, secure integrations across modern IT and security ecosystems. only) and best suited for engineers who excel in fast-moving startup environments where autonomy, rapid iteration, and strong technical judgment are essential.
Principal Scientist, Antibody Discovery and Engineering ModernaTXPrincipal Scientist, Antibody Discovery and EngineeringCambridge, MassachusettsThis individual will operate with a high degree of independence, scientific judgment, and cross-functional influence while partnering with antigen design, structural and computational biology, Immuno-oncology and Autoimmune Therapeutics research leadership, project teams, and external CRO partners. We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities.
Principal Engineer, Data Infrastructure KlaviyoPrincipal Engineer, Data InfrastructureBoston, MA$244,000–$366,000 / yearIn addition to base salary, our total compensation package may include participation in the company’s annual cash bonus plan, variable compensation (OTE) for sales and customer success roles, equity, sign-on payments, and a comprehensive range of health, welfare, and wellbeing benefits based on eligibility. AI‑augmented data operations: Semantic discovery and auto‑documentation cover the majority of high‑value datasets; AI‑assisted DQ monitors reduce data incidents on top pipelines by 25–40%; pipeline authoring and review times drop 15–25% with AI in the loop.
Principal Scientist, Protein Design ModernaTXPrincipal Scientist, Protein DesignCambridge, MassachusettsThis role will lead the design, execution, and continuous advancement of high-throughput mammalian cell–based screening platforms that interrogate broadly applicable design principles for glycoprotein antigens, enabling antigen optimization, improved expression and durability across multiple programs, and rapid maturation of computationally designed candidates. The candidate in this position will work closely with and report to the Senior Director, Computational Design and In Vitro Selection, and will also work closely with the VP, Protein Design, as well as other members of Research, to advance novel candidates to the clinic, drive exploratory trials to inform the generation of improved vaccine antigens and explore new concepts for mRNA medicines.
Principal AI/ML Researcher WhoopPrincipal AI/ML ResearcherBoston, MassachusettsDeep expertise in modern deep learning (transformers, state space models), multimodal training, self-supervised and representation learning, RL-based post-training (PPO/DPO/GRPO), and large-scale distributed training (data, model, and context parallelism). At WHOOP, we view total compensation as the combination of base salary, equity, and benefits, with equity serving as a key differentiator that aligns our employees with the long-term success of the company and allows every member of our corporate team to own part of WHOOP and share in the company’s long-term growth and success.
Principal Software Engineer, Platform Engineering ModernaTXPrincipal Software Engineer, Platform EngineeringCambridge, MassachusettsThis is a senior individual contributor role that combines deep technical execution with cross-functional technical leadership across developers ("Builders"), Cybersecurity, Architecture, AI platform teams, and broader teams to provide scalable, secure, and user-focused capabilities that make the right path the easiest path for Moderna’s engineering teams. We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities.
Principal RA Associate Devices Fresenius Medical CarePrincipal RA Associate DevicesWaltham, MassachusettsResponsible for preparing FDA submissions necessary for new product approvals/clearances which include Premarket norifictoins-510(k)s, Premarket Approval Applications (PMAs) and supplements, Investigational Device Exemptions (IDEs) submissions. Serves as the primary regulatory resource for change to and prioritization of projects, resource assignment and efficient management of the development and change processes.
Senior/Principal Scientist Cell Based Potency Assay 3316 Takeda Development Center AmericasSenior/Principal Scientist Cell Based Potency AssayLexington, MassachusettsD. in cell biology, molecular biology, immunology, biochemistry, bioengineering, pharmaceutical sciences, statistics, biostatistics, or a related discipline with 3+ years of relevant experience for Senior Scientist or 7+ years for Principal Scientist; MS with 9+ years for Senior Scientist or 13+ years for Principal Scientist; or BS with 11+ years for Senior Scientist or 15+ years for Principal Scientist. Plan and coordinate work with departmental, cross-functional, and external stakeholders, including Process Development, Quality Control, contract testing laboratories, Analytical Sciences, Quality Assurance, Regulatory, and other Analytical Development teams.
Principal Scientist, mRNA-tLNP Analytical Development Kernal BiologicsPrincipal Scientist, mRNA-tLNP Analytical DevelopmentBoston, MassachusettsDevelop and qualify methods to characterize antibody–lipid bioconjugates and targeted LNPs, including conjugation efficiency, antibody-to-particle ratio and surface ligand density, free/unconjugated antibody, conjugate identity and integrity, and antigen-binding activity. Demonstrated expertise in developing analytical methods to test and characterize mRNA and LNP products, spanning both biophysical and biochemical techniques (particle size measurement, HPLC, LC-MS, CE, ELISA, qPCR, protein analysis, and in vitro potency assays).
Principal Carelon Research Biostatistician Elevance HealthPrincipal Carelon Research BiostatisticianNewton, MassachusettsThis researcher partners with investigators, research sponsors, academic institutions, and cross-functional project teams to design studies, develop statistical methodologies, oversee analytical execution, and communicate scientific findings that advance externally funded clinical research programs. The Principal Carelon Research Biostatistician is responsible for serving as the statistical lead for complex clinical research studies and represents an analytical thought leader across Carelon Research's clinical research portfolio.
Principal Engineer, CMC Development Pilot Operations ModernaTXPrincipal Engineer, CMC Development Pilot OperationsNorwood, MassachusettsThe Principal Engineer will partner closely with CMC Dev Quality, analytical testing laboratories, Process Development, Engineering, Safety, Digital, and the GMP manufacturing facility to ensure seamless material delivery, technical readiness, operational excellence, and robust transfer of product and process knowledge across the manufacturing network. We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities.
Principal Specialist, Quality Assurance Cardinal HealthPrincipal Specialist, Quality AssuranceMansfield, MassachusettsCross-functional Collaboration: Leads complex cross-functional projects to identify root causes of significant quality issues, educates stakeholders on quality requirements, and develops sustainable solutions to minimize future risks. The Principal Specialist, Quality Assurance, is a highly experienced individual contributor who applies advanced knowledge of quality assurance concepts and technical capabilities to drive uncompromised laboratory integrity and minimize risks.