Senior Scientist/Principal Scientist, Protein Science Synolo Therapeutics IncSenior Scientist/Principal Scientist, Protein ScienceCambridge, MAAbout RA Capital: RA Capital Management funds and builds healthcare and life science companies using an evidence-based investment approach informed by TechAtlas, a think tank within RA Capital which analyzes scientific and clinical data from academic literature and industry sources to anticipate how breakthroughs might impact industry stakeholders, physicians, patients, and policymakers. Experience working with large, multidimensional datasets and leveraging modern computational and AI-enabled tools (e.g., Python, workflow automation, AI coding assistants, interactive scientific applications, and data visualization platforms) to improve scientific productivity, data analysis, and decision-making.
Principal Platform Software Engineer, C++ Evolv Technologies IncPrincipal Platform Software Engineer, C++Waltham, MA$114,000–$184,000 / yearWe''re looking for a senior embedded Linux developer who can own the platform from the ground up - bringing up a custom Yocto-based Linux distribution, writing and debugging kernel drivers, and building the secure boot and provisioning pipeline that ships with our hardware. You''ll work directly with Electrical Engineering Hardware Engineers to translate schematics into working device drivers and device tree configurations, and partner closely with our senior IC on peripheral architecture and automated validation.
Principal Developer Solution Architect (Healthcare EMR/EHR, Ophthalmology) Saviance TechnologiesPrincipal Developer Solution Architect (Healthcare EMR/EHR, Ophthalmology)Boston, MARemoteThe ideal candidate has direct, hands-on experience with OpenEMR, strong AI/LLM fluency, and understands how ophthalmology practices and EHR/EMR systems integrate, including ophthalmology-specific clinical workflows and data structures. An organization is seeking a hands-on Principal Developer / Solution Architect to help design and build technical solutions at the intersection of healthcare EMR/EHR systems and ophthalmology-specific workflows.
Senior Director, Principal Gifts Brigham and Women's HospitalSenior Director, Principal GiftsBoston, MA$175,000–$200,000 / yearReporting to the Assistant Vice President of Development, Principal Gifts, the Senior Director is responsible for identifying, qualifying, cultivating, soliciting and stewarding donors to the Academic Medical Centers with a giving capacity in the 7- to 10-figure range. Philanthropy enables Mass General Brigham to deliver the highest quality patient care, pursue the most innovative and promising research, train the brightest minds to become the next generation of healthcare leaders, and expand and improve our world-class facilities.
Principal Product Manager Blend Financial IncPrincipal Product ManagerBoston, MA8+ years in product management with shipping reps in both a larger company (mature surface, real scale, real cross-functional rigor) and a small / early-stage company (01, no scaffolding, owned a P&L). To embrace talented people like this and provide the necessary resources to achieve their best versions, we believe in the power of a healthy environment where each person is valued for who they are and have clear goals and expectations for the future they can build within the company.
Principal Consultant - Aviation Noise HARRIS MILLER MILLER & HANSON INC.Principal Consultant - Aviation NoiseBURLINGTON, MARemoteWe are seeking a Principal Consultant – Aviation Noise to join our team in a remote or hybrid position in the U.S. In this senior role, you will serve as a recognized technical expert in aviation noise, leading large and complex projects, supervisingand mentoringstaff, shaping practice strategy, and expanding HMMH’s presence in the aviation noise field. Our Aviation Environmental & Sustainability Group supports over 200 airports worldwide with noise and air quality studies, sustainability plans, mitigation strategies, environmental documentation, and regulatory compliance.
Principal Product Manager - Low Voltage Veir IncPrincipal Product Manager - Low VoltageWoburn, MA$170,000–$200,000 / yearIn the first 6 months you'll Complete the full Preliminary Design phase product deliverable set for the SL Series in collaboration with SL Series subsystem product managers and product marketing manager, including application and use case presentations, product brochure, product presentations, guide specifications, product datasheets, and serviceability plan. The Principal PM is the primary product authority for VEIR's low voltage system platform - translating data center customer requirements into precise product direction, orchestrating subsystem product managers to ensure cohesive system-level execution, and serving as the product team's primary interface for commercial engagements.
Principal Electrical & Compliance Engineer Veir IncPrincipal Electrical & Compliance EngineerWoburn, MAVEIR is enabling a new generation of compact, efficient, high-power, and long-distance power delivery solutions, solving bottlenecks that exist across the entire electricity value chain, from generation through to data center server racks. What You'll Do Electrical Systems Integration Own the electrical integration interface designs between VEIR system and datacenter distribution systems, from medium-voltage (MV) switchgear and transformers through low-voltage (LV) switchgear, busway, PDUs, power sidecars, and rack busbars.
Principal Red Team Operator Citizens Financial Group IncPrincipal Red Team OperatorBoston, MA$120,000–$210,000 / yearOperating within high impact engagements, this individual will simulate real world attackers, identify and validate attack paths, and partner closely with defensive teams to ensure findings translate into measurable improvements in detection, response, and overall risk posture. Locations & Work Arrangement: Remote is not an option, candidates must be willing to commute to one of the following hub locations with a hybrid schedule of 4 days onsite and 1 day remote per week with flexibility in one of the following hubs: Phoenix.
Principal Consultant - Aviation Noise Harris Miller Miller & HansonPrincipal Consultant - Aviation NoiseBurlington, MassachusettsRemoteWe are seeking a Principal Consultant – Aviation Noise to join our team in a remote or hybrid position in the U.S. In this senior role, you will serve as a recognized technical expert in aviation noise, leading large and complex projects, supervisingand mentoringstaff, shaping practice strategy, and expanding HMMH’s presence in the aviation noise field. Our Aviation Environmental & Sustainability Group supports over 200 airports worldwide with noise and air quality studies, sustainability plans, mitigation strategies, environmental documentation, and regulatory compliance.
Principal Platform Engineer InterSystemsPrincipal Platform EngineerBoston, MA$110,000–$164,000 / yearAs a Principal Platform Engineer, you will serve as a hands-on technical leader, solving complex engineering challenges, shaping technical direction, and leading initiatives that improve developer productivity, platform reliability, and software delivery across the company. Our data platforms solve interoperability, speed, and scalability problems for large organizations around the globe to unlock the power of data and allow people to perceive data in imaginative ways.
Principal Product Manager UseoriginPrincipal Product ManagerBoston, Massachusetts6+ years in product management with shipping reps in both a larger company (mature surface, real scale, real cross-functional rigor) and a small / early-stage company (01, no scaffolding, owned a P&L). To embrace talented people like this and provide the necessary resources to achieve their best versions, we believe in the power of a healthy environment where each person is valued for who they are and have clear goals and expectations for the future they can build within the company.
Managing Principal, Strategic Accounts Odaia Intelligence Inc.Managing Principal, Strategic AccountsBoston, MAFull timeODAIA's SaaS platform transforms complex data into predictive, personalized insights, enabling commercial leaders to understand their customers, anticipate prescribing behaviors, and make the informed, strategic decisions that bring therapies to patients faster. A proven track record of building successful partnerships, advising commercial pharma executives, leading high-stakes conversations and influencing multi-million dollar commercial investment decisions through data-driven storytelling.
Principal Product Manager- Conversational AI Hopper IncPrincipal Product Manager- Conversational AIBoston, MARemoteHTS Assist is Hoppers agentic AI assistant for travel, resolving real customer issues like flight changes, cancellations, refunds, and bookings over chat and voice for some of the largest travel brands and enterprises in the world. This is a deliberately design-leaning role, and you will be the day-to-day design decision-maker, shaping flows and interfaces directly in close partnership with partner design teams and our in-house designer.
Principal Software Engineer Berkshire Hathaway Specialty Insurance CoPrincipal Software EngineerBoston, MAUse AI-assisted development tools, such as GitHub Copilot or similar platforms, to improve engineering productivity, code quality, testing, documentation, and developer experience while maintaining strong review, security, and compliance practices. Proven success in a Principal Engineer or equivalent leadership role, with deep expertise in designing and building scalable applications and integrating third-party platforms to meet complex business needs.
Principal, NYBC Ventures New York Blood Center IncPrincipal, NYBC VenturesBoston, MassachusettsFull timeNYBCe operates Blood Bank of Delmarva, Community Blood Center of Kansas City, Connecticut Blood Center, Memorial Blood Centers, Nebraska Community Blood Bank, New Jersey Blood Services, New York Blood Center, and Rhode Island Blood Center, delivering one million blood products to 400+ U.S. hospitals annually. This is an opportunity for a senior life sciences investor to take on significant deal ownership and portfolio leadership within one of the world's leading blood and biotherapeutics organizations, with direct exposure to a differentiated portfolio spanning hematology, cell therapy, biologics, and adjacent fields.
Principal Engineer, VaiDA Mobile Experience Vertex PharmaceuticalsPrincipal Engineer, VaiDA Mobile ExperienceBoston, Massachusetts$166,640–$250,000 / yearThe ideal candidate combines strong mobile engineering expertise with a sharp eye for usability, polish, and responsiveness, and can translate complex AI-driven functionality into clear, elegant mobile interactions. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Principal Analyst, G&A Technology Vertex Pharmaceuticals, IncPrincipal Analyst, G&A TechnologyBoston, MA$142,800–$214,200 / yearThe ideal candidate combines deep expertise in technology delivery, stakeholder engagement, and cross-functional leadership with a proven track record of partnering with Legal, Compliance, and Corporate Communications organizations in complex, highly regulated environments. In this role, you will partner closely with stakeholders to deliver technology solutions that strengthen operations, enhance the user experience, and support strategic priorities across corporate functions, with a particular focus on Legal, Compliance and Corporate Communication needs.
Principal Full Stack AI Engineer Vertex PharmaceuticalsPrincipal Full Stack AI EngineerBoston, Massachusetts$166,640–$250,000 / yearWe seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. In this role you will develop AI agents and the services, APIs, and interfaces around them, andconnect the platform to the systems, tools, and data sources that make AI valuable in real enterprise workflows.
Senior Principal AI Engineer Vertex PharmaceuticalsSenior Principal AI EngineerBoston, Massachusetts$188,000–$282,000 / yearWorking within the Agentic AI Platform team, thisrole will focus on delivering production-grade platform services for model integration, prompt and workflow orchestration, evaluation, observability, performance optimization, and agent lifecycle management. Own thedeveloper experiencefor the platform, delivering intuitive self-service onboarding, SDKs, CLIs, sandbox environments, reference implementations, and clear documentation that let builders move from idea to production quickly.