Wauwatosa, Wisconsin30+ days ago
Integrins, crucial cell surface receptors, play a pivotal role in regulating cell-cell and cell-matrix interactions across various biological processes, including development, hemostasis, antigen recognition, homing, and inflammation. Our goal is to illustrate the intricate mechanisms governing receptor-ligand interactions and the conformational changes necessary for transmembrane signaling, spanning the extracellular, transmembrane, and cytoplasmic domains.