Bioinformatics Scientist - Gene Regulation & Cellular Reprogramming e184Bioinformatics Scientist - Gene Regulation & Cellular ReprogrammingPortland, OregonPhD in Bioinformatics, Computational Biology, or related quantitative field (or MS with 5+ years relevant industry experience); Demonstrated track record applying computational TF ranking and GRN inference to cellular reprogramming problems, transdifferentiation, directed differentiation, or iPSC systems; Multi-platform single-cell RNA-seq expertise: hands-on analysis from at least two different platforms, including platform-specific troubleshooting and quality control; Multi-modal genomics proficiency: ChIP-seq, CUT&RUN, or ATAC-seq analysis including peak calling, differential accessibility, and TF motif enrichment; Hands-on experience with established GRN inference methods to nominate or rank regulators of cell state, beyond literature-curated lists; Experience analyzing pooled perturbation screens (CRISPRa, CRISPR knockout, or barcoded TF overexpression) with single-cell or bulk readouts; Working knowledge of trajectory inference and pseudotime methods for mapping cell state transitions; Strong programming skills in Python and R, with proficiency in Scanpy/Seurat and statistical analysis for high-dimensional data; Comfortable working in a modern computational environment: cloud platforms, workflow managers, containerization, and collaborative version control; Strong publication record and demonstrated cross-functional collaboration with experimental biologists. This role focuses on gene regulatory network inference, differential analysis of single-cell transcriptomics, and computational prioritization of TF cocktails for cellular reprogramming, requiring deep expertise in multi-platform scRNA-seq analysis and transcriptional regulation biology.
Computational Biologist 1 Oregon Health & Science UniversityComputational Biologist 1Portland, ORExpertise including RStudio, Shiny framework, GitHub code version control, Seurat, DESeq2, and have experience with bulk and single-cell dataset analysis workflows including data normalization, dimensionality reduction, and clustering. Their research is built around teamwork and covers four key areas: Precision Systems Oncology, Cancer Data Science (including computer biology, bioinformatics, and biostatistics), Chemical Biology and Experimental Therapeutics, and Cancer Population Science.
Staff Scientist Oregon Health & Science UniversityStaff ScientistPortland, OregonConduct advanced research in gamete, embryo, stem cell, and molecular biology, including gamete and embryo micromanipulation; in vitro gametogenesis (IVG) via somatic cell nuclear transfer (SCNT); genome editing and gene correction in gametes, embryos, and cultured cells; mitochondrial replacement therapy (MRT); induced pluripotent stem cell (iPSC) and embryonic stem cell (ESC) derivation, culture, and differentiation. Department Overview: The incumbent will provide advanced scientific expertise in genetics, epigenetics, transcriptomics, genome editing, sequencing technologies, and bioinformatics to support both research and clinical initiatives at the Center for Embryonic Cell and Gene Therapy (CECGT).
Scientist - Tech Transfer Twist Bioscience CorpScientist - Tech TransferPortland, ORIf you enjoy working in a fast-paced, multidisciplinary environment where you can directly impact how products are built and delivered at scale, this role offers broad exposure to cutting-edge synthetic biology platforms and technologies. You will play a key role in developing, optimizing, and troubleshooting workflows spanning molecular biology and mammalian cell culture systems, ensuring processes are robust, scalable, and production-ready.
Postdoctoral Scholar Oregon Health & Science UniversityPostdoctoral ScholarPortland, OregonHosseini MH, Kurtz SE, Abdelhamed S, Mahmood S, Davare, MA, Kaempf A, Elferich J, McDermott JE, Liu T, Payne SH, Shinde U, Rodland KD, Mori M, Druker BJ, Singer JK, Agarwal Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes. The OHSU Knight Cancer Institute is a pioneer in personalized cancer treatment and research, led by Dr. Brian Druker, whose development of Gleevec transformed Chronic Myeloid Leukemia from a fatal disease to a manageable one and proved that targeted therapies can work.
Informatician 3 Oregon Health & Science UniversityInformatician 3Portland, ORKey duties include independently designing, developing, and executing gene editing, sequencing analyses, and computational workflows, as well as building and maintaining bioinformatics pipelines, tools, and software for the analysis of high-throughput sequencing data derived from research participants, gametes, preimplantation embryos, and pluripotent stem cells. Independently design, develop, and implement computational tools, pipelines, workflows, and software packages to discover, analyze, and annotate genomic information from high-throughput sequencing data, including bulk and single-cell datasets derived from research participants, gamete donors, gametes, preimplantation embryos, and pluripotent stem cells.
Laboratory Technologist Centrillion Technologies, Inc.Laboratory TechnologistHillsboro, OregonMolecular Vision Laboratory (MVL), a CLIA-certified clinical service laboratory/molecular diagnostic laboratory based in Hillsboro, Oregon, is working on rare genetic conditions with the focus on eye diseases. MVL is part of Centrillion Biosciences, which has advanced research laboratories in US, China, and Taiwan for conducting research, development and commercialization of novel technologies in bioinformatics, genomics, chemistry, biochemistry, and molecular biology.