Principal Defense Systems Analyst STRPrincipal Defense Systems AnalystWoburn, Massachusetts$220,000–$260,000 / yearWe focus on the capability and limitations of ground, air, and space sensing and counter-sensing platforms (both crewed and uncrewed) and the resource management of these assets in the service of the survivability and capability of US air and space assets (e.g., the F-35 Joint Simulation Environment) using the methods of operational and systems analysis. You will lead and advise fellow researchers, scientists, and engineers on multi-disciplinary teams spread across multiple STR campuses to understand customer objectives, craft strategic plans, lead proposal efforts, and develop innovative solutions to complex and challenging national security problems.
Principal Key Account Manager External Hays CareersPrincipal Key Account ManagerCambridge, MassachusettsHays Life Sciences is a global leader in specialist recruitment, partnering with biotech, pharmaceutical, and medical device organizations across the U.S. We support high-growth, venture-backed companies as well as established industry leaders, delivering talent across Clinical Development, Medical Affairs, Regulatory Affairs, Biometrics, and Commercial functions. We have active employee resource groups which you can tap into from day one including the Pride Network, Black Excellence Network, WE Lead (for female leaders), and other employee resource groups supporting Veterans, Neurodiverse individuals, South Asians, and individuals interested in Sustainability.
NewPrincipal Scientist, Aseptic Control - MSAT Process Vertex PharmaceuticalsPrincipal Scientist, Aseptic Control - MSAT ProcessBoston, MassachusettsThis aseptic processing SME will partner with stakeholders to define strategies for microbial control of activities such as gowning, facility monitoring programs (EM, Water, Gases, etc.), disinfectant efficacy, aseptic processing simulations, filtration, particulate control, risk assessments, and will ensure the control strategies comply with industry guidance. Work closely with colleagues in Process development to design and implement new technologies for aseptic filling of cell therapy drug products in novel device platforms; this includes working closely with Contract Development and Manufacturing Organizations (CDMOs) and engineering firms to design processes and equipment needed to perform aseptic filling operations in a GMP environment.
Principal Scientist, Dmpk/Adme Zealand Pharma A/SPrincipal Scientist, Dmpk/AdmeCambridge, MA$184,200–$253,200 / yearCombining more than 25 years of peptide R&D expertise with a proprietary data platform that leverages advanced data-driven and AI/ML approaches, Zealand Pharma aims to lead a new era in obesity and metabolic health. 6+ years of relevant post-degree experience in DMPK/ADME (drug discovery, non-clinical studies), with complex drug modalities (e.g., antibody-peptide conjugates, peptides, antibodies).
Principal DevOps Engineer PTC IncPrincipal DevOps EngineerBoston, MA$118,000–$190,000 / yearOur platform brings the best of modern SaaS collaboration to 3D CAD - think SolidWorks meets GitHub meets Google Docs - and is used globally by teams building the next generation of products. Today, we are a global team of nearly 7,000 and our main objective is to create opportunities for our team members to explore, learn, and grow - all while seeing their ideas come to life and celebrating the differences that make us who we are and the work we do possible.
Principal Clinical Trial Manager TransMedicsPrincipal Clinical Trial ManagerAndover, Massachusetts$151,500–$215,700 / yearThis position is responsible for, but not limited to, the following: Leading the process of pre and post market clinical trials for FDA by employing effective organizational strategies and reviewing and presenting the results using rigorous clinical procedures. Experience in medical device (strongly preferred), Outstanding track record leading large complex global clinical trials for medical device products in different phases of the product cycle.
NewGirls Basketball Coach - Melican Middle School The Public Schools of Northborough And SouthboroughGirls Basketball Coach - Melican Middle SchoolNorthborough, MADuties include: scheduling practices, daily practice plans, emailing parents and families, distribution and collection of medical forms, equipment management, uniform distribution, supervising games, and transportation to games. WORK ENVIRONMENT & PHYSICAL REQUIREMENTS: Work Environment: Work is generally performed after the school day, however there are some occasions that meetings will occur during the day.
NewGirls Basketball Coach - Trottier Middle School The Public Schools of Northborough And SouthboroughGirls Basketball Coach - Trottier Middle SchoolNorthborough, MADuties include: scheduling practices, daily practice plans, emailing parents and families, distribution and collection of medical forms, equipment management, uniform distribution, supervising games and transportation to games. WORK ENVIRONMENT & PHYSICAL REQUIREMENTS: Work Environment: Work is generally performed after the school day, however there are some occasions that meetings will occur during the day.
Senior Principal Software Engineer/Architect UKG IncSenior Principal Software Engineer/ArchitectLowell, MA$207,400–$298,100 / yearM&A technical leadership: Lead technical diligence for acquisitions affecting Ready: evaluate architecture fit, identify integration risks (data, security, compliance), design migration/integration plans, and lead or advise post-close execution to minimize customer and delivery risk. Hands-on technical leadership: Own high-risk or high-impact technical work (POCs, performance optimizations, complex integrations), mentor architects and senior engineers, and lead architecture reviews and decision records.
Principal CAD Engineer Mercury Systems IncPrincipal CAD EngineerAndover, MASelf-motivated - candidate should enjoy leading and taking ownership of assigned projects, exhibit good written and verbal communication skills, and have the ability to work well in a diverse team environment. Job Summary: Join a focused team of engineers bringing highly complex, dense, rugged and secure electronic packaging solutions to our nation's warfighters and first responders.
Principal Software Engineer State Street CorpPrincipal Software EngineerBurlington, MA$178,131–$230,000 / yearAssume Scrum master responsibilities when required; Provide thought leadership in the design of product architecture within the team's scope of responsibility; work under minimal supervision to build out the next generation of our software test automation infrastructure as part of our Quality Assurance Infrastructure team to test, and debug medium to large software enhancements and solutions within Charles River's business and technical problem domains; responsible for designing, developing, delivering and supporting the software infrastructure that enables automated product validation to Charles River's customer and to the rest of the development community at Charles River Development; assist in driving mature test automation capabilities, such as BDD/ATDD capabilities that allow teams to shift testing and test automation as far left as possible; improve the Testing/automation architecture by continuously reducing the testing cycle time enabling the CI\CD models by working closely with various teams; assist in improving development test methodologies, and contribute to related test methodology frameworks; conduct manual tests to ensure a high-quality end product; and contribute to written design and API documentation, and participate in customer testing process. Specific duties include: Architect, design, develop, test, debug, and implement software programs, applications and projects using Java, C#, React, and other related software engineering languages; Design and model Relational databases and develop efficient and performant database SQLs; Design Services/APIs which are independent and easily upgradeable adhering to cloud native development principles; Lead cross functional initiatives by collaborating with teams, product owners and other engineers to drive to common solutions; Mentor junior staff; Provide informed guidance and direction in code reviews; write unit and automation tests to ensure a high-quality end product; Actively participate in the agile software development process by adhering to the CRD Scrum methodology, including attending all daily standups, sprint planning, backlog grooming, and retrospectives.
Principal Cybersecurity Engineer Avenue Technologies CompanyPrincipal Cybersecurity EngineerMarlborough, MassachusettsAvenue Technologies is seeking a Principal Cybersecurity Engineer to support technical, engineering, and program teams in a hands-on environment. Coordinate with engineering and program teams to maintain secure and compliant systems.
NewPrincipal Technical Program Manager Cambridge Mobile TelematicsPrincipal Technical Program ManagerCambridge, MA$124,000–$155,000 / yearChampion cross-functional collaboration among senior leaders within software engineering, product management, and customer success teams to ensure seamless and efficient release processes at a strategic level. Experience driving programs that span machine learning, software engineering, product, and customer-facing teams, including ML model readiness, data dependencies, experimentation, and operational rollout.
Principal Technical Program Manager, App Lila SciencesPrincipal Technical Program Manager, AppCambridge, MassachusettsFull-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program. LILA combines advanced AI models with proprietary AI Science Factory instruments into an operating system for science that executes the entire scientific method autonomously, accelerating discovery at unprecedented speed, scale, and impact across medicine, materials, and energy.
Raven StealthCo - Principal Scientist, In Vivo Pharmacology RavenRaven StealthCo - Principal Scientist, In Vivo PharmacologyBoston, MassachusettsThe team is small, the work deeply cross-functional, and priorities shift, so we want someone thoughtful, highly organized, and energized by a fast-paced start-up, with significant latitude to shape how we run in vivo pharmacology and a clear path to grow in scope and leadership as the organization matures. As one of our earliest and more senior hires, this person helps shape a culture we are deliberate about: rooted in psychological safety, where good ideas are welcomed from any seat, respect is paramount, failure is a chance to learn rather than a cause for blame, and mentorship is the spine of strong teams.
Principal | Digital Advisory Leader Buro Happold LtdPrincipal | Digital Advisory LeaderBoston, MA$200,000–$336,000 / yearBuilding on the success of our established Digital Advisory practices in the UK and Middle East, this role will play a critical part in shaping and scaling our US offering while contributing to Buro Happold's global strategy in building a market-facing consulting platform, originating executive-level opportunities, growing strategic accounts, and contributing directly to Buro Happold's commercial and strategic growth in the US and globally. This is a unique opportunity to build a market-leading advisory capability that helps clients unlock value through digital strategy, transformation, systems, solutions, data, and analytics across asset-intensive industries and the built environment.
Principal Engineer, AI Security Lila Sciences IncPrincipal Engineer, AI SecurityCambridge, MA$171,000–$230,534 / yearMulti-Layer AI Security (Network, Endpoint, Data) - Integrate AI security into existing enterprise security layers: network visibility and control over AI service access, API traffic inspection, and zero trust enforcement; endpoint security for developer machines, research environments, browsers, and plugins; data layer controls ensuring proper handling of sensitive data when interacting with AI systems. While Lila builds AI-powered systems, this role is primarily focused on securing the use of third-party and internally deployed AI tools across the enterprise - ensuring sensitive data, intellectual property, and scientific workflows are protected as AI becomes deeply embedded in how work gets done.
Principal Software Engineer, Onsite RTXPrincipal Software Engineer, OnsiteMassachusettsActive and existing security clearance required on day 1 At RTX, the world's largest aerospace and defense company, 185,000 great minds are united by purpose and inspired to make a difference solving the world’s most complex problems. Collins Aerospace, an RTX company, is a leader in engineering and proposal teams to successfully execute programs and prepare responsive proposals aimed at making the world a safer place.
NewPrincipal Systems Engineer, Product Owner - Radar Analysis and Verification - AN/TPY-2 RTXPrincipal Systems Engineer, Product Owner - Radar Analysis and Verification - AN/TPY-2Woburn, MassachusettsAbility to obtain INTERIM U.S. government issued security clearance is required prior to start date At RTX, the world's largest aerospace and defense company, 185,000 great minds are united by purpose and inspired to make a difference solving the world’s most complex problems. Operating in the X‑band portion of the electromagnetic spectrum, it provides high‑resolution target identification, enabling it to distinguish real threats from non‑threats such as launch debris.
Principal Engineering Designer CHA Consulting IncPrincipal Engineering DesignerBoston, MA$48–$58 / hourIn this senior-level role, you will lead the design and production of complex transportation deliverables supporting urban and rural roadways, intersections, streetscapes, rail lines, and major capital improvements. This is an exciting opportunity to mentor junior designers and collaborate with multidisciplinary teams to deliver accurate, coordinated solutions that strengthen transportation networks and the communities they serve.