Principal Scientist, Systems And Disease Biology SanofiPrincipal Scientist, Systems And Disease BiologyCambridge, MA$122.25–$176.58 / hourD. in systems biology, computational biology, biostatistics, or related quantitative field with proven experience in a relevant disease area (Immunology, Neurology or Oncology) OR PhD in biological sciences, biomedical sciences, immunology, neuroscience, oncology or in a related disease area and proven advanced track record of data analytics, ML/AI, or computational biology. Leading projects involving internal experiment design and data analytics as well as outsourcing of established workflows and/or complex follow-up mechanistic assays (organoid, CRISPR, proteomics).
Principal Scientist, Computational Protein Design ModernaTXPrincipal Scientist, Computational Protein DesignCambridge, MassachusettsWe are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. This individual will work in close partnership with structural biology, directed evolution, immunology, translational science, and program teams to advance platform innovation and therapeutic programs across Moderna’s Research and Early Development portfolio.
Principal AI/ML Researcher WhoopPrincipal AI/ML ResearcherBoston, MassachusettsDeep expertise in modern deep learning (transformers, state space models), multimodal training, self-supervised and representation learning, RL-based post-training (PPO/DPO/GRPO), and large-scale distributed training (data, model, and context parallelism). At WHOOP, we view total compensation as the combination of base salary, equity, and benefits, with equity serving as a key differentiator that aligns our employees with the long-term success of the company and allows every member of our corporate team to own part of WHOOP and share in the company’s long-term growth and success.
Principal Scientist, Protein Design ModernaTXPrincipal Scientist, Protein DesignCambridge, MassachusettsThis role will lead the design, execution, and continuous advancement of high-throughput mammalian cell–based screening platforms that interrogate broadly applicable design principles for glycoprotein antigens, enabling antigen optimization, improved expression and durability across multiple programs, and rapid maturation of computationally designed candidates. The candidate in this position will work closely with and report to the Senior Director, Computational Design and In Vitro Selection, and will also work closely with the VP, Protein Design, as well as other members of Research, to advance novel candidates to the clinic, drive exploratory trials to inform the generation of improved vaccine antigens and explore new concepts for mRNA medicines.
Principal Software Engineer, Platform Engineering ModernaTXPrincipal Software Engineer, Platform EngineeringCambridge, MassachusettsThis is a senior individual contributor role that combines deep technical execution with cross-functional technical leadership across developers ("Builders"), Cybersecurity, Architecture, AI platform teams, and broader teams to provide scalable, secure, and user-focused capabilities that make the right path the easiest path for Moderna’s engineering teams. We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities.
Senior/Principal Scientist Cell Based Potency Assay 3316 Takeda Development Center AmericasSenior/Principal Scientist Cell Based Potency AssayLexington, MassachusettsD. in cell biology, molecular biology, immunology, biochemistry, bioengineering, pharmaceutical sciences, statistics, biostatistics, or a related discipline with 3+ years of relevant experience for Senior Scientist or 7+ years for Principal Scientist; MS with 9+ years for Senior Scientist or 13+ years for Principal Scientist; or BS with 11+ years for Senior Scientist or 15+ years for Principal Scientist. Plan and coordinate work with departmental, cross-functional, and external stakeholders, including Process Development, Quality Control, contract testing laboratories, Analytical Sciences, Quality Assurance, Regulatory, and other Analytical Development teams.
Principal Engineer, CMC Development Pilot Operations ModernaTXPrincipal Engineer, CMC Development Pilot OperationsNorwood, MassachusettsThe Principal Engineer will partner closely with CMC Dev Quality, analytical testing laboratories, Process Development, Engineering, Safety, Digital, and the GMP manufacturing facility to ensure seamless material delivery, technical readiness, operational excellence, and robust transfer of product and process knowledge across the manufacturing network. We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities.
Principal Embedded Software Engineer Lexington Medical, Inc.Principal Embedded Software EngineerBedford, MA$180,000–$220,000 / yearThe embedded software operates under tight real-time, safety-critical constraints, directly driving electromechanical subsystems where milliseconds and failure modes matter, and you will be in the lab working through hardware-software integration issues alongside electrical and mechanical engineers, not just reviewing designs from a distance. This is a hands-on role: you will be building the embedded software for our surgical stapling platform yourself, writing code, integrating drivers, and debugging at the hardware level, while also owning the technical architecture and setting the long-term direction for embedded systems across the platform.
Principal Systems Engineer, Digital Lab Systems ModernaTXPrincipal Systems Engineer, Digital Lab SystemsNorwood, MassachusettsWe are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team.
NewPrincipal SDET – Linux Kernel Premier Global LinksPrincipal SDET – Linux KernelCambridge, MassachusettsPremier Global Links LLC is seeking an experienced Principal Software Development Engineer in Test SDET to lead test strategy, automation, and system-level validation for a highly distributed, Linux-based AI and compute platform. This is a senior technical leadership opportunity for an engineer who enjoys working at the Linux kernel level, solving complex infrastructure problems, and building scalable automated testing and continuous integration systems.
Principal SAP S/4HANA Architect & Lead WayfairPrincipal SAP S/4HANA Architect & LeadBoston, MA$160,225–$176,719 / yearThe SAP Engineering team is responsible for maintaining a highly complex SAP installation used in the Finance department for all General Ledger, Accounts Payable, and Accounts Receivable functions. Experience with high-volume integrations, understanding how SAP interacts with non-SAP systems (Java/Python microservices, cloud-native platforms).
Principal Biostatistician Statistics & Data Corporation (SDC)Principal BiostatisticianWaltham, MARemoteActively participate in writing statistical sections of protocols, preparing statistical analysis plans, preparing data deliverables for clinical study reports, interpreting analysis results, writing statistical sections of clinical study reports, and participating in meetings with drug regulatory agencies as required. · Typically a Master’s degree in biostatistics, statistics or other related, scientific field and four years of relevant professional experience; or a PhD in biostatistics, statistics or other related, scientific field and three years of relevant experience; or equivalent combination of experience, education, and/or demonstrated ability.
BAS Principal - Valuation, Financial Forensics, Litigation (VFL) LitmanGerson AssociatesBAS Principal - Valuation, Financial Forensics, Litigation (VFL)Woburn, MA$140,000–$230,000 / yearFull timespecializing in a given subset Education and Experience:Bachelor's degree in Accountancy, Marketing, Finance, or a related fieldMaster's degree in Accountancy, Marketing, Finance or a plan to pursue preferredOne or more of the following credentials: certified public accountant (CPA), certified valuation analyst (CVA), accredited in business valuation (ABV), chartered financial analyst (CFA), certified business appraiser (CBA), accredited senior appraiser (ASA), certified divorce financial analyst (CDFA) CPA, CVA, ABV, CBA, or ASA certification is required 10+ years' of recent experience in a related field, with a proven ability to lead and develop client relationships. Acts as the firm's preeminent resource in specific technical areasProvides advice and council to clients, partners, and staffManages client expectations, develop solutions, and champions the implementation of client needs and ideasConsistently meets client deadlines timely and adheres to delivering specific client scopesIdentifies and recommends additional services that would be beneficial to clientsProvides exceptional customer service, ensuring client understands services, processes, etc.
Principal Network Engineer Sun Life FinancialPrincipal Network EngineerWellesley Hills, MA$70,300–$105,500 / yearAdvanced proficiency in Infrastructure as Code (IaC) using Terraform or AWS CloudFormation , paired with experience utilizing Generative AI developer tools (e.g., Amazon Q , Amazon Bedrock , or AI coding assistants) to accelerate code generation, automate network compliance validation, and scale CI/CD network deployment pipelines. The ideal candidate will have strong experience designing, implementing, and supporting enterprise network infrastructure, with expertise in Cisco routing and switching technologies, WatchGuard firewalls, AWS networking services, Infrastructure as Code, and utilizing Generative Developer tools.
Principal, Fund Controller Partners Capital Investment Group LLPPrincipal, Fund ControllerBoston, MA$120,000–$170,000 / yearPart timeClients include Syracuse University, Sesame Workshop, INSEAD Business School, New York’s Metropolitan Opera, San Francisco Symphony, Eton College, Colorado College, several Oxford and Cambridge University Colleges, several family offices around the world, and senior executives from leading global investment firms. With $75B+ in assets under management, the firm constructs customized investment portfolios for its clients tapping into its deep network of partnerships with what we consider exceptional asset managers across all major asset classes.
Principal Analyst, Enterprise Architecture Forrester Research, Inc.Principal Analyst, Enterprise ArchitectureCambridge, MA$141,000–$229,000 / yearA Principal Analyst is expected to: Lead the Enterprise Solutions Architecture practice area, working across Forrester research teams, including the Technology Strategy and Executive Partner teams as well as Sales and Product to develop a complete research portfolio that drives customer delight and revenue. Job Requirements: At least 10 years of experience in a mix of roles as a director-level and above practitioner, enterprise architect, principal sales engineer, principal solutions architect, managing consultant, Director/Manager of Sales Engineering, or research analyst in an industry vertical or technology services.
Principal Analyst - Technology Resilience Forrester Research, Inc.Principal Analyst - Technology ResilienceCambridge, MA$141,000–$229,000 / yearThe Principal Analyst delivers research that encompasses: 1) modern technology resilience practices, skills, and culture; 2) drive research on key platforms, vendors and trends in data resilience, object storage, and recovery related markets; 3) brings the right mix of both strategic and technical delivery experiences; and 4) fosters a culture of collaboration across our research, sales, product, and customer success teams. Deep understanding of the following concepts and industry best practices: site reliability engineering (SRE), National Incident Management System (NIMS), the National Response Framework (NRF), availability zones, ISO 22301, NIST SP 800-34, blameless retrospectives, CAST, fault injection, proactive and continuous testing, business impact analysis, immutability, and tabletop exercises.
Principal Systems Developer - DevSecOps InterSystemsPrincipal Systems Developer - DevSecOpsBoston, MassachusettsThis technical leadership role in the Database Platforms (DP) department will contribute to InterSystems’ next generation cloud-native database platform product as well as the InterSystems IRIS, InterSystems IRIS for Health and InterSystems Health Connect database platforms. The Platform Operations team needs an experienced developer or architect who can drive DevSecOps enhancements and maintenance including configuration, security, monitoring, licensing and upgrading for cloud with Kubernetes and traditional on-prem deployments on a range of supported platforms.
Principal Clinical Content- Physician - Uptodate, Physician Editor, Neurology Wolters KluwerPrincipal Clinical Content- Physician - Uptodate, Physician Editor, NeurologyWaltham, MARemote$173,500–$310,000 / yearUpToDate editors work closely with outside authors, section editors, editors-in-chief, and peer reviewers to ensure the material is accurate and free of bias. In the remaining 10 to 20% time, Physician Editors should continue patient care activities, using their clinical experience to help ensure the content of the program is maximally useful at the point of care.
Principal Systems Developer - Devsecops InterSystemsPrincipal Systems Developer - DevsecopsBoston, MA$144,000–$205,000 / yearThis technical leadership role in the Database Platforms (DP) department will contribute to InterSystems' next generation cloud-native database platform product as well as the InterSystems IRIS, InterSystems IRIS for Health and InterSystems Health Connect database platforms. The Platform Operations team needs an experienced developer or architect who can drive DevSecOps enhancements and maintenance including configuration, security, monitoring, licensing and upgrading for cloud with Kubernetes and traditional on-prem deployments on a range of supported platforms.