Principal Scientist, Cancer Biology General ProximityPrincipal Scientist, Cancer BiologySan Francisco, CAPre-clinical characterization and mechanistic elucidation of small-molecule drug candidatesMechanistic studies of cancer cell signaling and PTM analysisPhenotypic assay development for cancer drug discovery (low to high throughput)Small molecule drug development campaigns (hit discovery, hit validation, dose-response studies, SAR and MOA studies)Proficiency in: Managing a team of exceptional scientists and research associatesTarget/indication selectionAnimal models of cancer (GEMM, orthotopic, xenograft models), in vivo study design, and PK/PD interpretationManaging CROs for in vitro and in vivo studiesGrant writingNice to have:Experience navigating IND-enabling studies and working on teams that have successfully advanced research to the clinicExperience working at the interface of cancer biology and chemistry Familiarity or experience with PROTAC/next-gen IPM technologiesExperience with PPI techniques (e.g., BRET, APEX/BioID, AlphaScreen etc.)BenefitsStrong equity incentives. Strong experience with:Cellular and molecular biology, including cancer cell line work and associated assays, stable cell line generation (lentiviral and CRISPR-based systems), co-IP/pull-down assays, RNA-seq, global proteomics, flow cytometry, plasmid design/cloning etc.
Scientist/Sr. Scientist, Chemical Biology General ProximityScientist/Sr. Scientist, Chemical BiologySan Francisco, CAYour responsibilities will include: supervising synthetic efforts with our CROs, designing, performing, and analyzing in cellulo assays, designing and optimizing first-in-class bifunctional molecules, collaborating with our Drug Discovery and IP team on patent applications, providing input for mechanistic studies on lead drug molecules, and spearheading forays into new disease areas. Experience with chemical biology techniques such as mammalian cell culture and cell-based assays (e.g., cytotoxicity assays, transfections, stable cell line generation, co-immunoprecipitation), and PPI assays (e.g., BRET, APEX/BioID, AlphaScreen).
Director, Small Molecule Discovery Biology (Inflammation & Autoimmunity) Alumis Inc.Director, Small Molecule Discovery Biology (Inflammation & Autoimmunity)San Francisco, CA$200,000–$240,000 / yearKey Responsibilities: Taking biology department responsibility in discovery-stage small molecule projects including conceptualizing project strategy, recognizing knowledge gaps, formulating screening paradigms, overseeing SAR generation, coordinating among project stakeholders, and identifying potential new targets. Overseeing development of both biochemical and cellular read-outs to support small molecule drug discovery efforts Support characterization of small molecule clinical candidates by employing autoimmune disease models and developing clinically relevant PD assays.
Director, HIgh-Throughput Biology Eikon Therapeutics IncDirector, HIgh-Throughput BiologyMillbrae, CA$213,000–$232,750 / yearEikons discovery platform is built on groundbreaking innovations from its founders (Nobel Prize, 2014), culminating in the creation of microscopes which enable real time, molecular-resolution measurements of protein movement in living cells, thereby unlocking otherwise intractable classes of proteins as drug targets. This role leads end-to-end high-throughput screening execution across automated and imaging-based platform technologies, ensuring delivery of scalable, reproducible, decision-enabling data that supports portfolio priorities.
Executive Director, Computational Systems Biology Revolution Medicines, Inc.Executive Director, Computational Systems BiologyRedwood City, CA$265,000–$331,000 / yearThe individual will lead a team of computational biologists and bioinformaticians focused on acquisition, organization, and analysis of large multi-omics data sets, using both public and proprietary data sources, that will help inform treatment strategies and guide patient stratification for a growing pipeline of RAS(ON) and targeted oncology therapeutics. The company's RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development.
NewHonors Physiology, Biology, and AVID 12 Teacher, Terra Linda High School San Rafael City SchoolsHonors Physiology, Biology, and AVID 12 Teacher, Terra Linda High SchoolSan Rafael, CAADD TO WISHLIST VIEW JOB WISHLIST APPLY (Current Employees ONLY) APPLY QUICK APPLY. Please utilize the custom link in this posting to apply, or the link titled "Apply Here!"
Principal Biologist - Cutaneous Biology Eli Lilly and CompanyPrincipal Biologist - Cutaneous BiologySan Francisco, CA$71,250–$187,000 / yearOur current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). The focus of the work will be to independently design, develop and validate biological assays to test and analyze molecule activities, investigate the mechanism of action of biological drugs, evaluate performance in various animal disease models, and ultimately to deliver preclinical evidence for future clinical testing.
Developmental Biology Faculty in Otolaryngology-Head & Neck Surgery Stanford UniversityDevelopmental Biology Faculty in Otolaryngology-Head & Neck SurgeryStanford, CA$196,000–$214,000 / yearThe Department of Otolaryngology - Head & Neck Surgery at Stanford University seeks a developmental biologist (PhD or MD) with interest in neurosensory biology to join the OHNS Department as Assistant Professor, Associate Professor or Professor in the University Tenure Line (UTL), University Medical Line (UML) or Non-Tenure Line-Research (NTL-R). We are particularly interested in candidates who have a strong background in stem cell biology and experience with combining multiple approaches, such as in vitro organoid methodologies and in vivo models, to investigate the development of sensory organs of the head and neck and to understand disorders of the hearing, vestibular, and/or olfactory systems.
Senior Scientist - Immunology Biology Arcus Biosciences IncSenior Scientist - Immunology BiologyHayward, CA$160,000–$175,000 / yearPHYSICAL REQUIREMENTS: Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds. The successful candidate will lead elements of drug discovery programs by providing scientific insight, generating robust experimental data packages, and developing mechanistic models of disease to advance Arcus drug candidates.
Scientist, Cell Biology & Antibody Engineering MedraScientist, Cell Biology & Antibody EngineeringSan Francisco, CaliforniaExecute developability assays to assess manufacturability and liability risks early — including thermal stability (DSF/DSC), aggregation and monomericity (HPLC-SEC), hydrophobicity (HPLC-HIC), polyspecificity/non-specific binding, and expression titer — and help triage candidates based on integrated characterization data. You will support our tissue culture operations, design and run in vitro and cell-based assays to characterize antibody candidates, and contribute to building out the lab capabilities that make all of this possible — from new assay formats to the automated workflows that execute them at scale.
Senior Scientist - Immunology Biology Arcus Biosciences, Inc.Senior Scientist - Immunology BiologyHayward, CA$160,000–$175,000 / yearPHYSICAL REQUIREMENTS: • Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds. The successful candidate will lead elements of drug discovery programs by providing scientific insight, generating robust experimental data packages, and developing mechanistic models of disease to advance Arcus drug candidates.
Scientist II, Structural Biology Revolution MedicinesScientist II, Structural BiologyRedwood City, California$132,000–$166,000 / yearThe company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. Interact with interdisciplinary teams (including chemists, computational chemists, biologists, project teams, and management) and clearly articulate structural data in a broader drug discovery context.
Scientist II, Structural Biology Revolution Medicines IncScientist II, Structural BiologyRedwood City, CA$132,000–$166,000 / yearThe company's RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. Interact with interdisciplinary teams (including chemists, computational chemists, biologists, project teams, and management) and clearly articulate structural data in a broader drug discovery context.
Scientist (Lung Biology/Lung Organoids) Dawar Consulting, Inc.Scientist (Lung Biology/Lung Organoids)South San Francisco, CASeeking a highly motivated Scientist to develop, characterize, and qualify advanced human lung complex in vitro models to support drug discovery, disease modeling, and translational safety assessment. This fully onsite role will work with innovative systems including lung organoids, air-liquid interface (ALI) cultures, co-culture models, and lung-on-a-chip/microphysiological platforms .
Forward Deployed Research Scientist (Biology) GoodfireForward Deployed Research Scientist (Biology)San Francisco, CaliforniaProject delivery and implementation – own research delivery on high-stakes projects with customers and do whatever it takes to make delivery successful, including: problem and hypothesis definition, data sourcing, tool building, iteration, and implementation. Treating models as black boxes is an unnecessary handicap—we have access to the structures inside them, and understanding those structures lets us steer what models learn, make them safer and more useful, and extract the vast knowledge they contain.
Lead Innate Immunity Cancer Cell Death Biology Astellas Pharma IncLead Innate Immunity Cancer Cell Death BiologySouth San Francisco, CAReporting to the Head of Innate Immunity & Cancer Cell Death Biology, the People Manager will balance project support with people management to enhance the quality and efficiency of ADC research. This position supports antibody-drug conjugate (ADC) research in oncology by contributing to multiple discovery programs while managing and developing a team of scientists.
Research Associate, Translational Biology (CONTRACT) SepternaResearch Associate, Translational Biology (CONTRACT)South San Francisco, CA$30–$40 / hourThe Veterinary Technician / Research Associate will initially be responsible for conducting in vivo rodent studies, with the potential to engage in additional ex vivo or in vitro studies in the Translational Sciences Department to support the advancement of Septerna's small molecule drug discovery pipeline. Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life-changing medicines for patients with the vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company.
Biology - Graduates - AI Training - San Francisco, US Prolific Academic LtdBiology - Graduates - AI Training - San Francisco, USSan Francisco, CAWe're looking for Biology Experts and Life Science Professionals to join our Expert Network to help train and evaluate cutting-edge AI models using real scientific expertise. We've built a unique platform that connects researchers and companies with a global pool of participants, enabling the collection of high-quality, ethically sourced human behavioural data and feedback.
Scientist II, Structural Biology Revolution Medicines, Inc.Scientist II, Structural BiologyRedwood City, CA$132,000–$166,000 / yearThe company's RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. Interact with interdisciplinary teams (including chemists, computational chemists, biologists, project teams, and management) and clearly articulate structural data in a broader drug discovery context.
Engineering Leader, Molecular Biology BenchlingEngineering Leader, Molecular BiologySan Francisco, CaliforniaFrom designing DNA constructs and analyzing protein sequences to performing gene editing experiments and modeling antibodies, we build the features that help scientists better plan, execute, and understand their research. We're particularly excited to hear from managers with a track record of obsessing over customer needs and product quality as they build their roadmaps and guide their team's execution.