NewSenior Scientist/Principal Scientist, Protein Science Synolo TherapeuticsSenior Scientist/Principal Scientist, Protein ScienceCambridge, MassachusettsAbout Synolo Therapeutics: About RA Capital: RA Capital Management funds and builds healthcare and life science companies using an evidence-based investment approach informed by TechAtlas, a think tank within RA Capital which analyzes scientific and clinical data from academic literature and industry sources to anticipate how breakthroughs might impact industry stakeholders, physicians, patients, and policymakers. Serve as the analytical and biophysical characterization lead on cross-functional project teams, partnering closely with Biologics Discovery, Biology, CMC, and external CROs to develop characterization strategies, solve complex scientific challenges, and ensure high-quality execution.
Principal Product Designer, Toast IQ Core (AI Product Team) Toast IncPrincipal Product Designer, Toast IQ Core (AI Product Team)MARemote$190,000–$304,000 / yearThis is a highly visible and hands-on individual contributor role where you will collaborate with cross-functional teams and work directly with conversational and service designers to create experiences that take full advantage of the breadth and depth of Toast's platform. Partner Collaboration: Strong communication skills and ability to work effectively in cross-functional teams, including product managers, engineers, GTM, data scientists and other stakeholders to define design requirements and align on goals.
Principal Software Engineer CVS Health CorpPrincipal Software EngineerMA$144,200–$288,400 / yearOperating as both a senior individual contributor and technical leader, you will partner closely with product, architecture, and engineering leadership to make pragmatic, high‑impact design decisions that balance speed, quality, and long‑term maintainability. Partner with teams and serve as subject matter expert to provide benchmarked solutions to multiple, complex technical projects/initiatives within own area of expertise and organize cross-departmental application architectural solutions.
Principal Product Manager, Agent Platform Toast IncPrincipal Product Manager, Agent PlatformMA$165,000–$264,000 / yearToast creates technology to help restaurants and local businesses succeed in a digital world, helping business owners operate, increase sales, engage customers, and keep employees happy. Your mission will be to make it easy for every product team at Toast to build, launch, and monitor high-quality AI agents while ensuring Toast IQ delivers a seamless, consistent, and trustworthy experience.
Senior Principal, AI Product Owner - LLMs Entegris IncSenior Principal, AI Product Owner - LLMsMA$175,000–$230,000 / yearThis is a senior, builder-level role: you'll shape the product portfolio, stand up the practice, establish governance and guardrails, and ensure the underlying data is AI-ready - partnering with business leaders, IT, data engineering, and data science to take solutions from concept to scaled production. 15+ years in enterprise data, software development practices and/or product management/ownership, including 4+ years delivering AI/ML or data products, with a track record of taking solutions to scaled production.
Principal Electrical & Electronics (E&E) Engineer - Test Solutions - Onsite (Tewksbury/Andover, MA) RTX CorpPrincipal Electrical & Electronics (E&E) Engineer - Test Solutions - Onsite (Tewksbury/Andover, MA)Tewksbury, MAOur engineers work hands‑on with the latest test instrumentation, software, and automation technologies to integrate state‑of‑the‑art test capabilities for some of the most advanced engineering systems in the world. Qualifications You Must Have: Typically requires Bachelor's degree in Science, Technology, Engineering, or Mathematics (STEM) and a minimum of eight (8) years of prior relevant experience OR an Advanced degree and five (5) years of relevant experience.
NewField Engineer or Principal Field Engineer Northrop Grumman CorpField Engineer or Principal Field EngineerNashua, NH$75,800–$113,800 / yearPreferred Qualifications: Preferred candidates will hold a degree in a relevant engineering or technical discipline, such as Electronics Engineering, Electrical Engineering, Computer Engineering, or Software Engineering. The above salary range represents a general guideline; however, Northrop Grumman considers a number of factors when determining base salary offers such as the scope and responsibilities of the position and the candidate''s experience, education, skills and current market conditions.
NewPrincipal Business Intelligence Analyst - Ambulatory Operations Dana-Farber Cancer Institute IncPrincipal Business Intelligence Analyst - Ambulatory OperationsBOSTON, MARemote$110,500–$123,300 / yearThe Principal Business Intelligence Analyst is a quantitative analytics professional who specializes in delivering actionable insights and analytics to business users, leveraging an enterprise analytics framework, infrastructure, and operating modelRelevant business areas that could be supported by the analyst span across clinical and operational areas, including but not limited to clinical operations, nursing, quality and patient safety, finance, HR, supply chain, strategy, pharmacy, clinical disciplines, and informatics solutions areas. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations.
OSS ESY Principal - Comprehensive Cambridge Public SchoolsOSS ESY Principal - ComprehensiveCambridge, MADescription of Service Opportunity Recruit and hire staff Order materials Create schedules Prepare summer curriculum Communicate with school teams. If you are a non-exempt employee and have worked more than 40 hours a week you will be paid time and a half for any hours worked over 40 hours.
Principal Scientist, Biophysicist Novartis AGPrincipal Scientist, BiophysicistCambridge, MA$119,700–$222,300 / yearD. (post-doc preferred), in a relevant scientific discipline (e.g., Biophysics, Biochemistry, Bioengineering, or a related field), with 2+ years of industrial experience in drug discoveryDeep expertise in designing, validating, executing and troubleshooting biophysical assays. Internal Job Title: Principal Scientist I/Principal Scientist IIPosition Location: onsite, La Jolla, CA #LI-onsiteWe are seeking a highly motivated and experienced Principal Scientist / Biophysicist to join our dynamic team in La Jolla, CA.
Associate Principal, Commercial Strategy Trinity Life SciencesAssociate Principal, Commercial StrategyWaltham, MA$156,000–$234,000 / yearTrinity's salary bands account for a wide range of factors that are considered in making compensation decisions including but not limited to skill sets and market demand for skills; level of experience and training; specific qualifications, performance, time in role/company, geographic location, and other business and organizational needs. For more than 30 years, the world's leading pharmaceutical, biotech, and medtech companies have relied on Trinity's foresight, execution, and partnership to deliver confident product launches, decisive market advantage, and measurable patient impact.
Principal Scientist, Structural Biologics Novartis AGPrincipal Scientist, Structural BiologicsCambridge, MA$108,500–$201,500 / yearEssential Requirements:PhD degree in biophysics, biochemistry, or related discipline with a proven record in experimental structural biology.3+ years experience (Postdoc or industry experience) in common protein purification methods (Affinity, IMAC, SEC) and molecular biology techniques (cloning, DNA isolation, transformation, etc.).Interest in using AI/ML methods in a structural biology context. Internal Job Title: Principal Scientist IPosition Location: San Diego, CA onsiteThe Biologics Research Center, Structural Biologics department is looking for a highly motivated Principal Scientist to support experimental structural biology across multiple biotherapeutic programs.
Principal Scientist, Structural Biology Novartis AGPrincipal Scientist, Structural BiologyCambridge, MA$119,700–$222,300 / yearKey Responsibilities:Lead and execute protein production and X-ray crystallography to elucidate protein-small molecule, protein-peptide, and/or protein-protein interactions, supporting drug discovery initiativesSuccessfully drive gene-to-structural small molecule drug discovery projectsLeverage knowledge in protein production and structural biology to characterize structure-function relationships, investigate novel mechanisms of action, and address complex scientific questionsCollaborate with cross-functional teams, including protein scientists, biophysicists, chemists, and computational modelers, to facilitate structure-based drug designAdvance our initiatives and drug discovery programs by leveraging innovative approaches, such as applications of AI.Essential Requirements:Ph. D. in structural biology, biophysics, biochemistry, or a related field with over 5 years of relevant experience in X-ray crystallography within either industrial or academic settingsDemonstrated expertise in protein expression across E. coli, insect, and mammalian expression systems, as well as extensive experience in protein purification and characterizationProven track record in application of X-ray crystallography to characterize protein-ligand and protein-protein complexes, including crystallization screening and optimization, data processing, structure refinement and analysis.
Principal Software Development Engineer CVS Health CorpPrincipal Software Development EngineerWellesley, MA$144,200–$288,400 / yearLeveraging your deep technical expertise, you will join a high-performing architecture team responsible for developing a cloud-native platform designed to transform healthcare experiences and improve the lives of hundreds of millions of consumers. As part of CVS Health's mission to transform health and wellness through engaging, best-in-class digital experiences, you will play a key role in building an integrated platform that powers innovative products, enhances consumer engagement, and helps revolutionize the future of health and wellness.
Principal Systems Developer - DevSecOps InterSystemsPrincipal Systems Developer - DevSecOpsBoston, Massachusetts$144,000–$205,000 / yearThis technical leadership role in the Database Platforms (DP) department will contribute to InterSystems’ next generation cloud-native database platform product as well as the InterSystems IRIS, InterSystems IRIS for Health and InterSystems Health Connect database platforms. The Platform Operations team needs an experienced developer or architect who can drive DevSecOps enhancements and maintenance including configuration, security, monitoring, licensing and upgrading for cloud with Kubernetes and traditional on-prem deployments on a range of supported platforms.
Principal Site Reliability Engineer, Machine Learning Cambridge Mobile TelematicsPrincipal Site Reliability Engineer, Machine LearningCambridge, MA$142,000–$177,600 / yearMaintain the observability of uptime, availability, and scalability of EKS Ray and Databricks workloads using CloudWatch and Datadog, including defining alerting that maps to SLOs. Responsibilities: Use independent judgment and discretion to own SLOs, error budgets, and the operational health of Ray clusters running on AWS EKS and Databricks workloads on AWS EC2 across multiple accounts and regions.