BrainEx is a proprietary closed-loop physiological system that functions as an artificial cardiovascular, pulmonary, and renal system for an intact human brain — custom hardware and software regulating circulatory volume, cerebral blood flow, systolic pressure and pulsatility, pH, dissolved gases, temperature, metabolites, and drug dosing throughout each run. Design fluidic and mechanical hardware in CAD (SolidWorks, Onshape, or similar): manifolds, sensor housings, reservoirs, bubble traps, sealed enclosures, and rig-integration hardware, with attention to O-ring and gasket sealing, dead-volume minimization, tolerance stack-ups, and biocompatible, cleanable material selection.