Senior Research Associate (Oligo Chemistry & Biochemistry) Wave Life Sciences LtdSenior Research Associate (Oligo Chemistry & Biochemistry)Cambridge, MA$72,000–$98,000 / yearOur diversified pipeline is focused on our obesity, alpha-1 antitrypsin deficiency and PNPLA3 I148M liver disease programs and includes clinical programs for Duchenne muscular dystrophy and Huntington's disease, as well as several preclinical programs utilizing our versatile RNA medicines platform. Our toolkit of RNA-targeting modalities including RNAi silencing and RNA editing provides us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology.
Scientist I, Guide RNA Chemistry, Prime Medicine Prime Medicine IncScientist I, Guide RNA Chemistry, Prime MedicineCambridge, MA$121,000–$147,000 / yearThe successful candidate will have hands-on experience in long guide RNA synthesis, chemical deprotection, purification, desalting, and the implementation of novel chemistries to enhance guide RNA potency and quality, along with proficiency operating MerMade 12 and/or Dr. Oligo synthesizers for solid-phase RNA synthesis using phosphoramidite chemistry, followed by HPLC purification to support multiple discovery programs. Depending on experience, this individual may mentor co-ops, contractors, or junior scientists and will work closely with cross-functional teams including Analytical Development, Biology, Formulation, and Technical Development & Operations (TDO) to advance Prime Medicine''s gene editing programs toward the clinic.
Scientist I, Guide RNA Chemistry Prime MedicineScientist I, Guide RNA ChemistryCambridge, MA$121,000–$147,000 / yearThe successful candidate will have hands-on experience in long guide RNA synthesis, chemical deprotection, purification, desalting, and the implementation of novel chemistries to enhance guide RNA potency and quality, along with proficiency operating MerMade 12 and/or Dr. Oligo synthesizers for solid-phase RNA synthesis using phosphoramidite chemistry, followed by HPLC purification to support multiple discovery programs. Depending on experience, this individual may mentor co-ops, contractors, or junior scientists and will work closely with cross-functional teams including Analytical Development, Biology, Formulation, and Technical Development & Operations (TDO) to advance Prime Medicine's gene editing programs toward the clinic.
Director/Senior Director, Computational Chemistry Flagship Pioneering IncDirector/Senior Director, Computational ChemistryCambridge, MA$176,000–$294,300 / yearCross-Functional Collaboration: Serve as a strategic scientific partner and computational chemistry leader across chemistry, biology, and in vivo pharmacology teams within the company; align on portfolio priorities, and represent the computational chemistry function in leadership discussions and external scientific forums. Molecular Design & Optimization: Define the strategic vision for and drive the design of heterobifunctional small molecules, including ligand selection, attachment vectors, and linker architectures, integrating cross-functional input to balance target engagement, molecular properties, and synthetic efficiency across programs.
MSAT Industrialization Leader, Drug Product Synthetics SanofiMSAT Industrialization Leader, Drug Product SyntheticsCambridge, MA$148.50–$214.50 / hourThrough close collaboration with R&D (CMC), QA, RA, Engineering, Manufacturing and MSAT teams and the Tech Transfer Leader, the Industrialization Lead ensures the process is ready for transition from development to reliable commercial supply. The DP Industrialization Lead ensures that drug product processes developed in late-stage R&D are robust, scalable, and manufacturable at commercial scale, enabling their successful transfer to manufacturing.
Msat Industrialization Leader, Drug Product Synthetics SanofiMsat Industrialization Leader, Drug Product SyntheticsCambridge, MA$148.50–$214.50 / hourThrough close collaboration with R&D (CMC), QA, RA, Engineering, Manufacturing and MSAT teams and the Tech Transfer Leader, the Industrialization Lead ensures the process is ready for transition from development to reliable commercial supply. The DP Industrialization Lead ensures that drug product processes developed in late-stage R&D are robust, scalable, and manufacturable at commercial scale, enabling their successful transfer to manufacturing.
Senior Associate Scientist / Scientist (Analytical R&D) CambrexSenior Associate Scientist / Scientist (Analytical R&D)Waltham, MassachusettsFull timeThe candidate should have a broad experience of method development of analytical technologies such as (U)HPLC, GC, KF, LC/MS, NMR, TGA, DSC, particle size analyzer etc. to characterize and quantitate pharmaceutical synthetic molecules. The successful candidate will join a team of innovative and entrepreneurial scientists dedicated to providing high-quality analytical support for synthetic process development projects.
Global Head Of Drug Substance Zealand Pharma A/SGlobal Head Of Drug SubstanceCambridge, MA$251,400–$307,300 / yearProvide global leadership and strategic direction for the Drug Substance function from early discovery to Phase 2. Lead synthetic route scouting and salt selection, evaluating alternative processes with yield, COGS, manufacturability, and scalability as key decision criteria. Combining more than 25 years of peptide R&D expertise with a proprietary data platform that leverages advanced data-driven and AI/ML approaches, Zealand Pharma aims to lead a new era in obesity and metabolic health.
Head of Drug Substance & Analytical Development Zealand Pharma ASHead of Drug Substance & Analytical DevelopmentCambridge, MAProvide global leadership and strategic direction for the Drug Substance function from early discovery to Phase 2. Lead synthetic route scouting and salt selection, evaluating alternative processes with yield, COGS, manufacturability, and scalability as key decision criteria. Combining more than 25 years of peptide R&D expertise with a proprietary data platform that leverages advanced data-driven and AI/ML approaches, Zealand Pharma aims to lead a new era in obesity and metabolic health.
Global Head of Drug Substance Zealand PharmaGlobal Head of Drug SubstanceCambridge, Massachusetts$251,400–$307,300 / yearProvide global leadership and strategic direction for the Drug Substance function from early discovery to Phase 2. Lead synthetic route scouting and salt selection, evaluating alternative processes with yield, COGS, manufacturability, and scalability as key decision criteria. Combining more than 25 years of peptide R&D expertise with a proprietary data platform that leverages advanced data-driven and AI/ML approaches, Zealand Pharma aims to lead a new era in obesity and metabolic health.
Global Head of Drug Substance Zealand Pharma U.S.Global Head of Drug SubstanceCambridge, Massachusetts$251,400–$307,300 / yearProvide global leadership and strategic direction for the Drug Substance function from early discovery to Phase 2. Lead synthetic route scouting and salt selection, evaluating alternative processes with yield, COGS, manufacturability, and scalability as key decision criteria. Combining more than 25 years of peptide R&D expertise with a proprietary data platform that leverages advanced data-driven and AI/ML approaches, Zealand Pharma aims to lead a new era in obesity and metabolic health.
Scientist, Oligonucleotide Synthesis GSK plcScientist, Oligonucleotide SynthesisCambridge, MA$96,525–$160,875 / yearGSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients' needs and have the highest probability of success. These responsibilities include some of the following: Support pre-clinical oligonucleotide high-throughput and mid-scale synthesis capabilities of ASOs, siRNA, SSO, and RNA editors with routine and novel next generation amidite chemistries.
Research Scientist, Strain and Enzyme Engineering ManusResearch Scientist, Strain and Enzyme EngineeringWaltham, MACross-Functional Collaboration: Communicate findings and work closely with colleagues across strain engineering, fermentation, analytical sciences, and downstream processing to accelerate development and improve experimental outcomes. In this role, you will apply creative, collaborative approaches to engineer microbial strains and enzymes, identify and overcome metabolic bottlenecks, and optimize pathways for improved biomanufacturing performance.
Director/Senior Director, Molecular Discovery Lila Sciences IncDirector/Senior Director, Molecular DiscoveryCambridge, MA$202,400–$323,400 / yearThis role leans heavily into the AI and computational side of our workflow: you will be accountable for throughput, quality, and the operational health of the discovery engine, working hand-in-hand with AI scientists, computational chemists, and platform engineers to diagnose bottlenecks, close feedback loops, and continuously improve how the platform performs. Direct experience with automated, high-throughput, or closed-loop discovery environments (e.g., self-driving labs, robotic synthesis and screening platforms), you''ve seen what it takes to make these systems produce real drug discovery output, not just proof-of-concept demos.
Associate Engineering Fellow -Process Knowledge & Data Architecture Takeda Pharmaceutical Co LtdAssociate Engineering Fellow -Process Knowledge & Data ArchitectureCambridge, MA$154,400–$242,550 / yearWorking across matrix teams, the individual will define and implement SMPD's data and knowledge strategy, enable data-driven decision-making, model development, and digital workflows, transforming fragmented datasets into a unified, high-value knowledge layer that accelerates development, improves process understanding, and supports lifecycle management. Communication Skills -Able to express oneself clearly and concisely within team; documents issues and/or concerns concisely with colleagues; adjusts communication style as appropriate for the audience; timely and effectively communicates with senior management; technical writing skills to support authorship and approval of internal technical documents.
Head of Drug Product Analytical Operations Ironwood Pharmaceuticals IncHead of Drug Product Analytical OperationsBoston, MA$214,000–$249,795 / yearThe role provides strategic and technical leadership across Technical Operations, Quality, Regulatory CMC, and external partners to support development, technical transfers, process validation, regulatory submissions, clinical bulk supply readiness, commercial preparedness, and lifecycle management. Drug Product, Medical Device, and Combination Product Development within CMC Activities: Lead analytical strategy for drug products, devices, and combination products, including methods, characterization, stability, extractables and leachables, and peptide-specific support.
Head Of Drug Product Analytical Operations Ironwood Pharmaceuticals, Inc.Head Of Drug Product Analytical OperationsBoston, MA$214,000–$249,795 / yearThe role provides strategic and technical leadership across Technical Operations, Quality, Regulatory CMC, and external partners to support development, technical transfers, process validation, regulatory submissions, clinical bulk supply readiness, commercial preparedness, and lifecycle management. Drug Product, Medical Device, and Combination Product Development within CMC Activities: Lead analytical strategy for drug products, devices, and combination products, including methods, characterization, stability, extractables and leachables, and peptide-specific support.
Lab Operations Specialist Flagship Pioneering IncLab Operations SpecialistWatertown, MA$72,000–$103,000 / yearFlagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Lab Operations Specialist Abiologics IncLab Operations SpecialistWatertown, MA$72,000–$103,000 / yearFlagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Lab Operations Specialist Flagship Pioneering, Inc.Lab Operations SpecialistWatertown, MA$72,000–$103,000 / yearFlagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.