NewPrincipal Engineer, Core Infrastructure Oracle CorpPrincipal Engineer, Core InfrastructureSan Francisco, CA$114,600–$234,600 / yearDefines and enforces scalability requirements for owned components; optimizes code and data paths for high‑throughput, hyper‑scale workloads; and leverages data plane platforms for large‑scale retrieval, storage, and processing. Continuous Improvement: -Develops ideas, recommends updates, and/or collaborates on the implementation of process improvements to increase the efficiency and effectiveness of processes, protocols, and workflows across teams, and evaluates the impact on key stakeholders.
NewPrincipal Research Scientist - Evaluations Canva Pty LtdPrincipal Research Scientist - EvaluationsSan Francisco, CA$310,000–$420,000 / yearYou will own how Canva evaluates generative quality across the whole of Canva Research, including problems we have not framed yet: new modalities, evaluation that reflects real differences between content types, user segments and markets, and a much tighter link between what our metrics say and what users and the business actually experience. You will treat that correlation as a research problem: validating metrics against human preference and downstream product outcomes, quantifying judge bias, and catching benchmark saturation and contamination before they quietly stop telling us anything.
NewPrincipal Clinical Scientist DanaherPrincipal Clinical ScientistSan Francisco, CA$120,000–$165,000 / yearThe essential requirements of the job include: Bachelor's degree in Life Sciences, Healthcare, or a related field with 9+ years of experience in clinical research, specifically with significant experience in US and/or EU trials, or a Master's degree with 12+ years of experience or Doctoral degree with 4+ years of same experience. It would be a plus if you also possess previous experience in: Experience in study designs for diagnostic technologies (IVD) is highly preferred, specifically for Clinical Chemistry, Immunoassays, Hematology, Urinalysis, Flow Cytometry, and/or Biomarkers.
Principal, Insights & Innovation Samba TV IncPrincipal, Insights & InnovationSan Francisco, CA$120,000–$150,000 / yearThe Principal, Insights & Innovation pairs deep data and statistical expertise with strong business acumen and industry knowledge to develop new, cutting-edge solutions and thought leadership in media intelligence, spanning behavioral and contextual targeting, media planning and insights, measurement, activation and optimization. Personality and communication (soft skills): An exceptional storyteller and presenter who distills complex statistical work into simple, compelling narratives for non-technical audiences; consultative and skilled at customer discovery; credible and poised with customers and sellers; and able to influence without authority while evangelizing new ideas internally.
NewPrincipal Scientist-Bioanalysis Prellis Biologics IncPrincipal Scientist-BioanalysisBerkeley, CAYou will develop and execute bioanalytical assays that support molecular characterization, PK/PD, and preclinical development of Prellis's next-generation biologic candidates, including antibody-peptide conjugates, bispecific/multispecific antibodies, and Fc-fusion proteins. The heart of Prellis Bio's strategy is the combination of novel, cutting-edge methods in machine learning, biology at scale, and next-gen antibody discovery that address long-standing industry-wide problems in the drug development pipeline.
Principal Software Engineer - TeraWave RF and Optical Systems Blue Origin Enterprises LPPrincipal Software Engineer - TeraWave RF and Optical SystemsSan Francisco, CA$230,773–$323,081.85 / yearand/or transports placardable amounts of hazardous materials by ground in any vehicle on a public road while in commerce, may be subject to additional Federal Motor Carrier Safety Regulations including: Driver Qualification Files, Medical Certification (obtained before onboarding), Road Test, Hours of Service, Drug and Alcohol Testing, vehicle inspection requirements, CDL requirements (if applicable) and hazardous materials transportation/shipping training. Responsibilities include but are not limited to: Own software architecture and design one or more system areas and represent them in cross-team discussions with chief architects and peer technical leaders, conduct trade studies and develop prototypes to identify architectural options, and propose the best path forward.
Senior Scientist-Principal Scientist Prellis Biologics IncSenior Scientist-Principal ScientistBerkeley, CAPrellis Biologics is an AI-driven therapeutics company developing the EXIS platform, an integrated, rapid, immune-guided discovery and engineering engine that combines machine learning, biology at scale, and proprietary 3D-printed human lymph node organoids to deliver validated antibody drug candidates in weeks. Assay design & development: Design, optimize, and validate cell-based functional assays (e.g., HTRF, reporter, on-cell binding, phospho-signaling readouts) from conception through tech transfer to routine screening use, supporting cardiometabolic programs as well as I&I and IO pipelines.
Principal Surveyor or above ABS Group of Companies IncPrincipal Surveyor or aboveSan Francisco, CAThe Principal Surveyor's primary role is to directly perform survey activities in accordance with ABS Rules, Guides, and all statutory requirements; while acting as a peer leader, knowledge resource, coach, and overall survey process expert at the port, station, or field site level. What You Will Do: Directly execute and support safe and efficient survey activities to meet business outcomes related to service delivery, labor/productivity, budget, quality, policy, compliance, training, development, and safety.
Principal Associate Scientist -Scientist - Immunology Prellis Biologics IncPrincipal Associate Scientist -Scientist - ImmunologyBerkeley, CAIndependently analyze and evaluate data including but not limited to immunological population dynamics, mRNA seq data, BCR sequence data, TCR sequence data, as well as monoclonal antibody characteristics to identify human blood donors with high potential of success in Prellis' ex vivo immunization system. You''ll collaborate closely with a multidisciplinary team to develop innovative lymph node organoids, design and execute impactful in vitro assays, and contribute your expertise to in vitro immune process development and antigen/antibody biomolecular engineering.
NewPrincipal Scientist - Therapeutic Antibody Characterization Prellis Biologics IncPrincipal Scientist - Therapeutic Antibody CharacterizationBerkeley, CAWe work hard to bring together diverse teams - grounded in a wide range of expertise and life experiences - and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. We are committed to empowering our pharmaceutical partners with access to the most promising fully human antibody candidates rapidly identified from the human immune repertoire, enabling them to bring life-changing treatments to patients faster than ever before.
Lead Principal Application Software Engineer- Forward Deployed Engineer Oracle CorpLead Principal Application Software Engineer- Forward Deployed EngineerPleasanton, CA$104,600–$264,100 / yearYou will combine deep hands-on engineering expertise with executive-level consulting, leading complex migrations from Databricks, Snowflake, Azure, AWS, and hybrid environments while defining reusable delivery patterns that shape Oracle CSS best practices. You will work directly with CIOs, CDOs, CTOs, chief architects, and engineering leaders to accelerate AI adoption, modernize legacy data estates, and deliver production-ready analytics and Generative AI solutions.
Principal Security Engineer, Infrastructure Security OpenAI LLCPrincipal Security Engineer, Infrastructure SecuritySan Francisco, CAFor unincorporated Los Angeles County workers: we reasonably believe that criminal history may have a direct, adverse and negative relationship with the following job duties, potentially resulting in the withdrawal of a conditional offer of employment: protect computer hardware entrusted to you from theft, loss or damage; return all computer hardware in your possession (including the data contained therein) upon termination of employment or end of assignment; and maintain the confidentiality of proprietary, confidential, and non-public information. As a principal engineer, you will set technical direction and drive execution on high-impact infrastructure security programs, partnering across various orgs at OpenAI to deliver durable controls that raise the security bar at OpenAI scale.
Principal Software Engineer - Frontend, Developer Experience Palo Alto NetworksPrincipal Software Engineer - Frontend, Developer ExperienceSan Francisco, IllinoisYou will collaborate directly with Product, Design, and engineering peers to build interfaces that help developers navigate complex environments with petabytes of telemetry data, turning that data into actionable, easy-to-understand visualizations and workflows. For candidates who receive an offer at the posted level, the starting base salary (for non-sales roles) or base salary + commission target (for sales/com-missioned roles) is expected to be the annual range listed below.
Sr Principal / Architect Engineer Software - Backend, Alerting (Chronosphere) Palo Alto NetworksSr Principal / Architect Engineer Software - Backend, Alerting (Chronosphere)San Francisco, CaliforniaDesign, implement, and deliver complex product features that address key customer pain points, collaborating closely with cross-functional teams—including product management, design, and engineering—to ensure alignment and impact throughout the development lifecycle. For candidates who receive an offer at the posted level, the starting base salary (for non-sales roles) or base salary + commission target (for sales/com-missioned roles) is expected to be the annual range listed below.
NewPrincipal Consumer Product Marketing Manager Contractor GoFundMe, Inc.Principal Consumer Product Marketing Manager ContractorSan Francisco, CA$91–$125 / hourPartner closely with PMs, Engineers, Researchers, and Designers to inform product strategy and roadmap through consumer insights, competitive landscape, market dynamics, and a deep understanding of emerging cultural trends shaping user behavior. Mastery of product storytelling, messaging frameworks, and positioning across varied user segments and lifecycle stages, paired with prolific writing skills that translate complex ideas into clear, compelling narratives across channels.
Principal Cloud Security Architect NextpowerPrincipal Cloud Security ArchitectFremont, CaliforniaWe are seeking a highly skilled Principal Cloud Security Architect with deep experience designing and securing distributed systems that span embedded devices, edge components, and cloud-based infrastructures. At Nextpower, we are driving the global energy transition with an integrated clean energy technology platform that combines intelligent structural, electrical, and digital solutions for utility-scale power plants.
Senior Principal Software Engineer, Jira Data Management Atlassian CorpSenior Principal Software Engineer, Jira Data ManagementSan Francisco, CAOur work is guided by three forces that will power the Jira Platform flywheel: AI TRANSFORMATION: Make Jira the agent-native system of record and control plane for human and agent teamwork, designing systems that enable people and AI agents to work together effectively. EFFICIENCY: Create a platform with sound unit economics that accelerates developer productivity, supports a growing agentic workload, and delivers world-class reliability for Jira Cloud customers.
NewData Science Principal SlackData Science PrincipalSan Francisco, CA$197,300–$313,700 / yearWhat you'll be doing: Establish strong partnership with product and business stakeholders in identifying opportunities, prioritize roadmaps, define and implement execution excellence, and coach and mentor team members for execution excellence. As Slack builds out its next generation of Platform capabilities, you'll lead the efforts on unearthing insights and building a complete picture of what users build and how they engage with agents and with each other on the Slack platform.
NewPrincipal AI Researcher InnovaccerPrincipal AI ResearcherSan Francisco, CAIn this role, you will work closely with product, engineering, and data teams to design, develop, and deploy AI-powered applications, including LLM-based solutions, AI agents, retrieval-augmented generation (RAG), and intelligent automation workflows. Depth beyond coursework: first-author publications at NeurIPS, ICML, ICLR, ACL, EMNLP, or similar; meaningful open-source ML contributions; a research internship at an AI lab; or models you trained and shipped that people actually used.
Principal Product Manager - AI Security (CoreAI) MicrosoftPrincipal Product Manager - AI Security (CoreAI)San Francisco, CA$142,800–$274,800 / yearThere is a different range applicable to specific work locations, within the San Francisco Bay area and New York City metropolitan area, and the base pay range for this role in those locations is USD $188,000 - $304,200 per year. This includes integrating AI security capabilities with Microsoft’s broader security stack - including Microsoft Defender, Entra, Purview, and Azure AI Foundry - to deliver a comprehensive security platform for AI systems.