Principal Product Designer MoonpigPrincipal Product DesignerManchester, NHWe’re proud to have a number of employee-led groups driving this forward, including our LGBTQ+, Gender Balance, Neurodiversity and EMBRACE (Educating Myself for Better Racial Awareness and Cultural Enrichment) communities, plus our Group-wide EDI committee. Wellbeing First: Private healthcare (UK) and mental health support ️ Flexible Working & Time Off: Generous holidays, hybrid working (1-3 days in office, depending on role/team) & up to 20 days of international working.
Principal Systems Engineer, Digital Lab Systems ModernaTXPrincipal Systems Engineer, Digital Lab SystemsNorwood, MassachusettsWe are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team.
Principal SDET – Linux Kernel Premier Global LinksPrincipal SDET – Linux KernelCambridge, MassachusettsPremier Global Links LLC is seeking an experienced Principal Software Development Engineer in Test SDET to lead test strategy, automation, and system-level validation for a highly distributed, Linux-based AI and compute platform. This is a senior technical leadership opportunity for an engineer who enjoys working at the Linux kernel level, solving complex infrastructure problems, and building scalable automated testing and continuous integration systems.
Principal Thermal Mechanical Engineer FlexPrincipal Thermal Mechanical EngineerLittleton, MA$153,500–$211,000 / yearWhat a typical day looks like: Lead the initial design, analysis, and optimization of complex fluid systems from concept initial CAD to final detailed CAD and drawing for liquid cooling, including cold plates, pumps, fluids, tubing, and heat exchangers, for the latest computer processing chipsets. The Principal Mechanical Engineer will provide technical leadership, mentorship, and hands-on expertise in mechanical design, fluid dynamics, and heat transfer but also work closely with customers in communicating the art of the possible with JetCool technology and building a strong customer relationship on a technical level.
Principal Engineer - Security Products, Security Visibility DigitalOceanPrincipal Engineer - Security Products, Security VisibilityBoston, MARemote$235,200–$294,000 / yearEvolve the Audit Logging Platform: Lead the redesign of DigitalOcean's audit log infrastructure to support immutable, tamper-evident, compliance-grade event records with fine-grained retention controls, cross-account federation, and real-time streaming access for customers and internal security teams. Core Experience: You possess over 10 years of software engineering expertise, including 4+ years dedicated to audit logging, security telemetry, SIEM integration, or managing high-throughput data pipelines within cloud or IaaS ecosystems.
Principal Engineer, Core Infrastructure KlaviyoPrincipal Engineer, Core InfrastructureBoston, MA$244,000–$366,000 / yearIn addition to base salary, our total compensation package may include participation in the company's annual cash bonus plan, variable compensation (OTE) for sales and customer success roles, equity, sign-on payments, and a comprehensive range of health, welfare, and wellbeing benefits based on eligibility. AI‑enabled platform: Approved AI tooling is integrated into IDE/CI/CD with repo policies and auditability; 70% MAU among eligible engineers; MTTR down 20-30% via AI‑assisted triage; flaky‑test rate decreases through targeted, AI‑suggested fixes.
Principal Carelon Research Biostatistician Elevance HealthPrincipal Carelon Research BiostatisticianNewton, MassachusettsThis researcher partners with investigators, research sponsors, academic institutions, and cross-functional project teams to design studies, develop statistical methodologies, oversee analytical execution, and communicate scientific findings that advance externally funded clinical research programs. The Principal Carelon Research Biostatistician is responsible for serving as the statistical lead for complex clinical research studies and represents an analytical thought leader across Carelon Research's clinical research portfolio.
Principal Scientist SanofiPrincipal ScientistWaltham, MA$122.25–$176.58 / hourThe Genomic Medicine Unit (GMU) CMC group at Sanofi is dedicated to the establishment of best-in-class manufacturing platforms to support development of life-changing advanced cell and gene therapy products, including recombinant AAV vectors, lentiviral vectors and cell therapy products. Main responsibilities: Lead scale-up activities from bench scale to pilot scale (200L-2000L), applying engineering principles (mixing, mass transfer, shear stress, dissolved oxygen control) to ensure process comparability at large scale.
Principal Scientist, Computational Protein Design ModernaTXPrincipal Scientist, Computational Protein DesignCambridge, MassachusettsWe are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. This individual will work in close partnership with structural biology, directed evolution, immunology, translational science, and program teams to advance platform innovation and therapeutic programs across Moderna’s Research and Early Development portfolio.
Principal Ai/Ml Researcher WhoopPrincipal Ai/Ml ResearcherBoston, MA$270,000–$300,000 / yearDeep expertise in modern deep learning (transformers, state space models), multimodal training, self-supervised and representation learning, RL-based post-training (PPO/DPO/GRPO), and large-scale distributed training (data, model, and context parallelism). At WHOOP, we view total compensation as the combination of base salary, equity, and benefits, with equity serving as a key differentiator that aligns our employees with the long-term success of the company and allows every member of our corporate team to own part of WHOOP and share in the company's long-term growth and success.
Principal Consultant AppianPrincipal ConsultantBoston, MA$100,000–$225,000 / yearKnowledge of software testing practices (test-driven development, automated test suites within a continuous integration framework); integrations experience using APIs such as REST and SOAP, JDBC connections, and web services; familiarity with Amazon Web Services (AWS), Artificial Intelligence (AI), Analytics, Machine Learning, Google Cloud, Application Integration, Database, Developer Tools, Management & Governance, and Elastic Containers is preferred. This includes working within an agile environment to understand our client's business processes and technical needs, launch new relational data models in production, developing APIs to integrate with multiple systems, partnering with Appian Architects and Technical Delivery Managers, and leading/mentoring consultants through fast-paced software implementations.
Principal RA Associate Devices Fresenius Medical CarePrincipal RA Associate DevicesWaltham, Massachusetts$109,000–$183,000 / yearResponsible for preparing FDA submissions necessary for new product approvals/clearances which include Premarket norifictoins-510(k)s, Premarket Approval Applications (PMAs) and supplements, Investigational Device Exemptions (IDEs) submissions. Serves as the primary regulatory resource for change to and prioritization of projects, resource assignment and efficient management of the development and change processes.
Principal Scientist, mRNA-tLNP Analytical Development Kernal BiologicsPrincipal Scientist, mRNA-tLNP Analytical DevelopmentBoston, MassachusettsDevelop and qualify methods to characterize antibody–lipid bioconjugates and targeted LNPs, including conjugation efficiency, antibody-to-particle ratio and surface ligand density, free/unconjugated antibody, conjugate identity and integrity, and antigen-binding activity. Demonstrated expertise in developing analytical methods to test and characterize mRNA and LNP products, spanning both biophysical and biochemical techniques (particle size measurement, HPLC, LC-MS, CE, ELISA, qPCR, protein analysis, and in vitro potency assays).
Principal Engineer, CMC Development Pilot Operations ModernaTXPrincipal Engineer, CMC Development Pilot OperationsNorwood, MassachusettsThe Principal Engineer will partner closely with CMC Dev Quality, analytical testing laboratories, Process Development, Engineering, Safety, Digital, and the GMP manufacturing facility to ensure seamless material delivery, technical readiness, operational excellence, and robust transfer of product and process knowledge across the manufacturing network. We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities.
Principal Program Manager – Embedded Aerospace Systems - 3643776 HRU-TechPrincipal Program Manager – Embedded Aerospace Systems - 3643776Hudson, New HampshireIn this role you will lead highly diverse cross functional teams composed of contracts, program planning, finance, operations, and engineering, to develop next-generation high-performance embedded processing solutions. You will support programs across our Compute Line of Business, where we design, develop, and produce embedded computers, networking appliances, storage solutions, and integration processing subsystems.
Principal Embedded Software Engineer Lexington Medical, Inc.Principal Embedded Software EngineerBedford, MA$180,000–$220,000 / yearThe embedded software operates under tight real-time, safety-critical constraints, directly driving electromechanical subsystems where milliseconds and failure modes matter, and you will be in the lab working through hardware-software integration issues alongside electrical and mechanical engineers, not just reviewing designs from a distance. This is a hands-on role: you will be building the embedded software for our surgical stapling platform yourself, writing code, integrating drivers, and debugging at the hardware level, while also owning the technical architecture and setting the long-term direction for embedded systems across the platform.
NewPrincipal Design Quality Engineer Fresenius Medical CarePrincipal Design Quality EngineerLawrence, MassachusettsDeep understanding and experience with Design Control techniques including Design Planning, Design Inputs, Design Outputs, Design Reviews, Design Verification, Design Validation, Design Changes, Design Transfer, and Design History Files (Design and Development Files). Investigates root cause solutions for product release through nonconformance reports (NCR), corrective and preventative actions (CAPA), and material containment and hold forms (MCH) and affected lot hold forms (ALH).
NewAssociate Principal Scientist, In Vivo Pharmacology, Oncology Merck & Co IncAssociate Principal Scientist, In Vivo Pharmacology, OncologyBoston, MA$144,800–$227,900 / yearRequired Skills: Immunoassays, Immunohistochemistry (IHC), Immunology, In Vivo Models, In Vivo Studies, Mass Spectrometry Imaging, Molecular Biology, Mouse Models, Multiplex Assays, Oncology, Pharmacodynamics, Pharmacokinetics, Pharmacology, Preclinical Research, Tumor Biology. EDUCATION: PhD in Oncology, Pharmacology, Biology, Pharmaceutical Sciences, Chemistry, Immunology, Biotechnology, Molecular and Cell Biology, or related STEM field with 5+ years of industry / biotech experience in Oncology drug discovery, or an MS with 7+ years of experience, or a BS with 10+ years of experience.
Client Service Principal, Taxable Partner's CapitalClient Service Principal, TaxableBoston, MassachusettsProactively identify and mitigate potential risks related to client accounts, working internally to identify, assess, and mitigate risks associated with client accounts and operational processes. Hands-on experience servicing US taxable clients (HNW families and family offices), including multi-entity household structures, tax-aware investment operations, and coordination with external CPAs and trust & estate counsel.
Principal, Data Engineer American TowerPrincipal, Data EngineerWoburn, MADay to day you will design and evolve the enterprise data platform, lead complex solution design, and embed governance enforcement through technical controls. We are seeking a Principal Data Engineer to join American Tower's Information Technology organization's Data & Analytics team.