Principal Software Engineer, Instrument Simulations Lila SciencesPrincipal Software Engineer, Instrument SimulationsCambridge, Massachusetts$204,000–$270,000 / yearFull-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program. LILA combines advanced AI models with proprietary AI Science Factory instruments into an operating system for science that executes the entire scientific method autonomously, accelerating discovery at unprecedented speed, scale, and impact across medicine, materials, and energy.
Principal Analyst - Enterprise CX Transformation Forrester Research, Inc.Principal Analyst - Enterprise CX TransformationCambridge, MA$141,000–$229,000 / yearYou'll conduct visionary original research that helps senior CX executives across industries build the experiences and CX programs of the future - and you'll advise these leaders on how to customize and implement your findings. In this role, you'll examine how senior CX leaders build and operate cutting-edge CX programs and drive enterprisewide customer-led innovation amid the rise of AI and volatility.
Senior/Principal Scientist, Small Molecule Therapeutics Lila SciencesSenior/Principal Scientist, Small Molecule TherapeuticsCambridge, Massachusetts$148,000–$208,000 / yearFull-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program. Automation-forward mindset: experience operating in automation- and robotics-enabled labs, including liquid handling integration, assay automation, and designing scalable, reproducible experimental workflows.
Principal Technical Program Manager, App Lila SciencesPrincipal Technical Program Manager, AppCambridge, Massachusetts$204,000–$270,000 / yearFull-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program. LILA combines advanced AI models with proprietary AI Science Factory instruments into an operating system for science that executes the entire scientific method autonomously, accelerating discovery at unprecedented speed, scale, and impact across medicine, materials, and energy.
Principal Engineer, Geostructural - Mi-Tech Services, Inc. Michels CorporationPrincipal Engineer, Geostructural - Mi-Tech Services, Inc.Boston, Massachusetts$138,000–$207,000 / yearA Principal Engineer is a leadership role that focuses on overseeing and driving the technical direction of projects for specific geographical regions or scopes of engineering services. Currently holding a Structural Engineer (SE) license or having passed the NCEES 16-hour structural engineering exam with which to obtain an SE license via comity without additional testing needed.
Principal Software Engineer, Berxi Vets HiredPrincipal Software Engineer, BerxiBoston, MassachusettsWe are seeking a highly skilled Principal Software Engineer to lead the design and delivery of scalable, cloud-native digital platform solutions in a direct-to-customer environment. This role plays a key part in shaping technical strategy, mentoring engineering teams, and building secure, high-performance applications that drive business growth.
Principal Performance Test Engineer BlockHiresPrincipal Performance Test EngineerBoston, MassachusettsWe are uniquely positioned at the center of global trading activity, processing over 100 million financial transactions every day, pioneering industry-wide, post-trade solutions and maintaining multiple data and operating centers worldwide. This highly technical position is responsible for the performance engineering of DTCC distributed computing environments and providing analytical stress evaluations of applications/systems and service level compliance using statistical, analytical, and simulation methods.
Principal Manufacturing Engineer Avenue Technologies CompanyPrincipal Manufacturing EngineerTewksbury, MassachusettsAvenue Technologies is seeking a Principal Manufacturing Engineer to support technical, engineering, and program teams in a hands-on environment. Lead or support root cause, corrective action, and continuous improvement activities using data-driven methods.
Principal System Safety Engineer Avenue Technologies CompanyPrincipal System Safety EngineerWoburn, MassachusettsAvenue Technologies is seeking a Principal System Safety Engineer to support technical, engineering, and program teams in a hands-on environment. Coordinate across engineering, program, and customer-facing teams to identify hazards and define effective controls.
Principal Cybersecurity / Threat Hunter Analyst Vets HiredPrincipal Cybersecurity / Threat Hunter AnalystBoston, MassachusettsThis role is ideal for a technical cybersecurity leader passionate about proactively identifying adversaries, strengthening threat detection, and driving rapid, intelligent incident response. The successful candidate will collaborate closely with security engineers and analysts to enhance cyber defense strategies, elevate security maturity, and protect enterprise systems from evolving threats.
Principal Software Engineer Vets HiredPrincipal Software EngineerBoston, MassachusettsThe ideal candidate brings deep technical expertise, strong leadership, and a hands-on approach to building high-impact systems in a fast-paced, collaborative environment. This role plays a critical part in shaping technology strategy, driving architectural excellence, and mentoring engineering teams to support evolving business platforms.
Principal Clinical Trial Manager TransMedics Group, Inc.Principal Clinical Trial ManagerAndover, MA$137,100–$193,700 / yearThis position is responsible for, but not limited to, the following: Leading the process of pre and post market clinical trials for FDA by employing effective organizational strategies and reviewing and presenting the results using rigorous clinical procedures. Experience in medical device (strongly preferred), Outstanding track record leading large complex global clinical trials for medical device products in different phases of the product cycle.
Staff/Principal DevOps Engineer, AI Inference Lila SciencesStaff/Principal DevOps Engineer, AI InferenceCambridge, Massachusetts$192,000–$272,000 / yearFull-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program. This role bridges platform engineering, site reliability, and ML infrastructure, building the systems that power low-latency, high-throughput inference across GPU clusters and cloud accelerators.
Principal Engineer, AI Security Lila SciencesPrincipal Engineer, AI SecurityCambridge, Massachusetts$255,000–$348,000 / yearMulti-Layer AI Security (Network, Endpoint, Data) — Integrate AI security into existing enterprise security layers: network visibility and control over AI service access, API traffic inspection, and zero trust enforcement; endpoint security for developer machines, research environments, browsers, and plugins; data layer controls ensuring proper handling of sensitive data when interacting with AI systems. While Lila builds AI-powered systems, this role is primarily focused on securing the use of third-party and internally deployed AI tools across the enterprise — ensuring sensitive data, intellectual property, and scientific workflows are protected as AI becomes deeply embedded in how work gets done.
Principal Cybersecurity Engineer Avenue Technologies CompanyPrincipal Cybersecurity EngineerMarlborough, MassachusettsAvenue Technologies is seeking a Principal Cybersecurity Engineer to support technical, engineering, and program teams in a hands-on environment. Coordinate with engineering and program teams to maintain secure and compliant systems.
Principal SoC Architect - Hardware NVIDIAPrincipal SoC Architect - HardwareWestford, MassachusettsYou have meaningful industry expertise in SoC architecture definition - Clocks, Resets, Automotive safety, Interconnects, Memory Controller, Boot, Virtualization, Power Management, Security, System Performance, IO technologies, (PCIE, Camera Interfaces, etc), Multimedia accelerator pipelines, CPU/GPU coherency, Platform integration. In this position, you will have the chance to define future aspects of our architectures that bring together NVIDIA GPUs, custom processors and accelerators into a single chip.
Principal Manufacturing Engineer-NPI TransMedicsPrincipal Manufacturing Engineer-NPIAndover, MassachusettsPOSITION SUMMARY: The Principal Engineer – NPI Manufacturing serve as the technical project leader for NPI manufacturing activities, driving the development and commercialization of TransMedics perfusion set and OCS products. To accomplish this mission, we partner closely with transplant stakeholders worldwide and help expand their access to healthy donor organs, while delivering the highest quality technology, service, clinical care and outcomes.
Principal Associate I, Plant Quality Assurance - 2ND SHIFT ReplimunePrincipal Associate I, Plant Quality Assurance - 2ND SHIFTFramingham, Massachusetts$120,000–$155,000 / yearThe Principal Associate I/II, Plant Quality Assurance (PQA) reports to the Associate Director, Quality Assurance and is responsible for on-going Quality oversight to ensure real time quality oversight for Drug Substance, Drug Product, and all other production and QC testing activities according to current good manufacturing practices (cGMP), good documentation practices (GDP) and other applicable regulations. The RPx platform is designed to have a unique dual local and systemic activity consisting of direct selective virus-mediated killing of the tumor resulting in the release of tumor derived antigens and altering of the tumor microenvironment to ignite a strong and durable systemic response.
Principal Mechanical Engineer Berkshire Grey Inc.Principal Mechanical EngineerBedford, MAThe candidate must be highly experienced and autonomous with respect to designing, fabricating, and testing new designs, as well as launching new products into production and supporting systems fielded at customer sites. Significant experience designing systems that are used in industrial settings, expecting to balance cost and durability for maximum customer success over the capital equipment's full depreciation lifespan.
Principal Modeling And Simulation Engineer Berkshire Grey Inc.Principal Modeling And Simulation EngineerBedford, MAIn the role of Principal Modeling and Simulation Engineer, you will lead the development of high-fidelity simulation platforms and digital twins that drive system design, validation, and deployment. This role blends advanced software engineering with modeling and simulation, enabling rapid development, testing, and optimization of complex robotic systems.