Monte Rosa Therapeutics IncDirector / Associate Director - Toxicology Monte Rosa Therapeutics IncDirector / Associate Director - ToxicologyBoston, MAThis is an individual contributor role by designing, conducting or overseeing studies, analyze/interpret, and report in vitro, ex vivo, and in vivo non-GLP (or GLP studies conducted at CROs) nonclinical pharmacology, PK/PD, and/or toxicology studies, in collaboration with study monitors and other scientists. The discovery toxicologist interacts directly with multidisciplinary teams including biology, medicinal chemistry, DMPK, clinical science, and outside CROs in research and/or development projects to move discovery candidates into development.
Monte Rosa Therapeutics, IncNewDirector / Associate Director – Toxicology Monte Rosa Therapeutics, IncDirector / Associate Director – ToxicologyBoston, MassachusettsThis is an individual contributor role by designing, conducting or overseeing studies, analyze/interpret, and report in vitro, ex vivo, and in vivo non-GLP (or GLP studies conducted at CROs) nonclinical pharmacology, PK/PD, and/or toxicology studies, in collaboration with study monitors and other scientists. The discovery toxicologist interacts directly with multidisciplinary teams including biology, medicinal chemistry, DMPK, clinical science, and outside CRO’s in research and/or development projects to move discovery candidates into development.
Beam TherapeuticsNewAssociate Director / Director, Toxicology Beam TherapeuticsAssociate Director / Director, ToxicologyCambridge, MA$185,000–$260,000 / yearBeam's suite of gene editing technologies is anchored by base editing, a proprietary technology that is designed to enable precise, predictable and efficient single base changes, at targeted genomic sequences, without making double-stranded breaks in the DNA. Provide toxicology support for regulatory submissions and interactions with health authorities, including the authoring of nonclinical safety sections of US and international regulatory applications, and help resolve nonclinical safety queries.
Korro Bio IncAssociate Director / Director, Toxicology Korro Bio IncAssociate Director / Director, ToxicologyCambridge, MA$175,000–$260,000 / yearExperience designing, outsourcing, and overseeing nonclinical toxicology studies at external CROs, including international vendors; prior experience working with CROs in China (or broader APAC region) is highly desirable. By editing RNA instead of DNA, Korro is expanding the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability.
Antares TherapeuticsNewSr. Scientist/Principal Scientist, Toxicology (Small Molecule) Antares TherapeuticsSr. Scientist/Principal Scientist, Toxicology (Small Molecule)Boston, MA$160,000–$220,000 / yearAntares Therapeutics is seeking an enthusiastic and self‑motivated Senior Scientist/Principal Scientist, Toxicology to join the Nonclinical Development group and support nonclinical safety assessment activities from discovery through IND‑enabling stages across the Antares pipeline. The successful candidate will play a key role in the design, execution, and interpretation of nonclinical safety studies, working both hands‑on in the laboratory and in close collaboration with external CROs.
Centessa Pharmaceuticals PlcSenior Director, Toxicology CNS Specialist Centessa Pharmaceuticals PlcSenior Director, Toxicology CNS SpecialistBoston, MA$275,000–$300,000 / yearThe successful candidate will work independently to direct their own program work, provide day-to-day scientific guidance to entry-level toxicology staff, and collaborate closely with peers across nonclinical and development functions. Deep expertise supporting small molecule programs across discovery, IND-enabling, and early clinical development, with demonstrated experience advancing CNS-active candidates.
Inductive Bio IncToxicologist Inductive Bio IncToxicologistBoston, MALocationNew York City, San Francisco, or BostonEmployment TypeFull timeLocation TypeHybridDepartmentScienceOverviewApplicationAt Inductive Bio we're tackling the challenge of making drug discovery more efficient. In this role, you will help shape our scientific offering, ensure that our models are rigorously validated, and guide us toward solutions that have meaningful impact in real-world drug discovery programs.
Agios Pharmaceuticals IncNewSenior Manager/Associate Director, Global Safety Scientist, MSRM Agios Pharmaceuticals IncSenior Manager/Associate Director, Global Safety Scientist, MSRMCambridge, MA$153,541–$230,312 / yearManager level is expected to be between $131,035 and $196,553 annualized and the current base salary range for this position at the Associate Director level is expected to be between $153,541 and $230,312 annualized; final salary will be determined based on various factors including, but not limited to, years of relevant experience, job knowledge, skills and proficiency, degree/education, and internal comparators. The Global Safety Scientist will work closely with the Head of Safety Sciences and the Global Safety Leads and be responsible for leading and planning the development of aggregate safety reports, signal detection review, authoring and analyzing data for safety topic reports, and creation and update of risk management plans.
Bristol-Myers Squibb CoNewSenior Scientist, Discovery Biology Oncology Bristol-Myers Squibb CoSenior Scientist, Discovery Biology OncologyCambridge Crossing, MA$137,570–$166,706 / yearProficient with molecular and cellular biology related techniques, including but not limited to 2D/3D/spheroid cell culture and related cellular assays, Western blot and/or JESS, qRT-PCR, flow cytometry, proliferation and/or cytotoxicity assays (CyQuant, CTG, apoptosis, IncuCyte, etc.), ELISA, MSD and/or HTRF assays, colony formation assay, processing of DNA/RNA/protein, IP/Co-IP. In addition, the individual will coordinate with other functions, such as informatics and predictive science, lead discovery and optimization, in vivo pharmacology, and translational research teams to design/execute work related to patient stratification, identification of appropriate PD markers and assay development/transfer for miniaturization, among others to ensure timely project advancement.
Prime Medicine IncSenior Scientist, Safety Assessment Prime Medicine IncSenior Scientist, Safety AssessmentCambridge, MA$145,000–$177,000 / yearD. in toxicology or a related field with 6+ years of pharma/biotech experience in nonclinical safety assessment, or an M.S. in toxicology or a related field with 10+ years of experience in nonclinical safety assessment, the ability to work independently, provide domain expertise and leadership, as well as cross-functionally in a fast-paced, matrixed environment with a positive, flexible attitude. Position Overview We are seeking an enthusiastic, self-motivated Senior Scientist to join the Nonclinical Development group, supporting the nonclinical safety assessment function for IND-enabling programs across Prime Medicines pipeline.
Bristol-Myers Squibb CoNewSenior Dir, In-Vivo & Non-Clinical Pharmacology Bristol-Myers Squibb CoSenior Dir, In-Vivo & Non-Clinical PharmacologyCambridge Crossing, MA$252,640–$306,137 / yearThis leader will partner deeply with Research leadership and the Pharmacology, DMPK, Toxicology, and Translational Science units to deliver the applications, workflow capabilities, AI, and supporting data flows that enable non-clinical decisions across in-vivo biology, DMPK, ADME, non-clinical safety, toxicology, and bioanalytical science. Non-clinical pharmacology generates the evidence that determines which candidates enter humans, and this role matters now because scientists need better integrated applications, AI, and workflows to generate, interpret, and act on that evidence with greater speed and confidence.
Alnylam Pharmaceuticals IncScientist Investigative Sciences Alnylam Pharmaceuticals IncScientist Investigative SciencesMADevelop and implement cell-based and biochemical assays to assess receptor binding signaling endocytosis and trafficking to support novel ligand candidate derisking and selection. Expertise in characterizing receptor-ligand interactions and downstream cell signaling or cellular function readouts is highly desired.
Prime MedicineNewSenior Scientist, Safety Assessment Prime MedicineSenior Scientist, Safety AssessmentCambridge, MA$145,000–$177,000 / yearD. in toxicology or a related field with 6+ years of pharma/biotech experience in nonclinical safety assessment, or an M.S. in toxicology or a related field with 10+ years of experience in nonclinical safety assessment, the ability to work independently, provide domain expertise and leadership, as well as cross-functionally in a fast-paced, matrixed environment with a positive, flexible attitude. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.
SanofiSenior Clinical Lead, Early Clinical & Experimental Therapeutics SanofiSenior Clinical Lead, Early Clinical & Experimental TherapeuticsCambridge, MA$236,250–$341,250 / yearIn these roles, duties include: Design safe, rapid and informative First-In-Human studies for oncology assets potentially including natural history, experimental model validation, mechanistic and signal seeking, streamlined Proof-of-Mechanism as well as Proof-of-Concept studies providing robust data for early Go/No Go decisions and other pharmacokinetic studies. A key focus of this role is to support the path from the research phase through early clinical development including early and rapid Proof-of-Mechanism/Proof-of-Concept, as well as natural history studies and experimental model validation to contribute to Human Target Validation (HTV) and evaluating the pharmacology of novel therapeutic approaches.
Rhythm PharmaceuticalsDirector, Nonclinical Development Rhythm PharmaceuticalsDirector, Nonclinical DevelopmentBoston, MAFull timePropose, design, and oversee nonclinical toxicology, DMPK, and ADME studies at external CROs (GLP and non‑GLP), providing scientific oversight of protocols, execution, data interpretation, and final reports, and managing CRO relationships, timelines, and budgets. Serve as the nonclinical development lead on cross‑functional program teams, providing scientific input to development strategy, risk assessment, and decision‑making across multiple programs.