NewPrincipal Scientist, Structural Biology NovartisPrincipal Scientist, Structural BiologySan Diego, CaliforniaAnalytical Skill (Inactive), Analytical Skill (Inactive), Analytical Thinking, Chemical Biology, Chemistry, Clinical Trials, Collaboration, Communication Skills (Inactive), Curious Mindset, Data (Inactive), Data Analysis, Design of Experiments (DOE), Detail-Oriented, Drug Development, Drug Discovery Process, Ethics, Gene Therapy, Immunology, Inventory Management, Laboratory (Inactive), Leading Project Teams, Lifesciences (Inactive), Machine Learning (ML), Management (Inactive), Medical Research {+ 10 more} This is a highly collaborative and hands-on role spanning end-to-end workflows from protein construct design and protein production through high-resolution structure determination, contributing directly to drug discovery programs across multiple therapeutic areas.
Principal Scientist - BioProcess Development Wacker Chemie AGPrincipal Scientist - BioProcess DevelopmentSan Diego, CA$140,000–$155,000 / yearAdobe will use this information on behalf of the owner of the Website to evaluate how users use the Website, to generate reports about website activity, and to provide the website owner with additional services relating to the usage of the Website and Internet usage. The Principal Scientist independently leads complex development programs, drives platform and technology innovation, and ensures successful technology transfer to Manufacturing and MSAT.
PRINCIPAL SCIENTIST- (Protein Immunotherapy) Scripps ResearchPRINCIPAL SCIENTIST- (Protein Immunotherapy)San Diego, CA$120,000–$150,000 / yearPart timeLeveraging the unique scientific environment of Scripps Research, impacting translational sciences, Calibr-Skaggs has created a portfolio of drug candidates, and is shaping a new paradigm for advancing nonprofit biomedical research to impact patients while re-investing in further innovative research. Design and execute project plans focused on comprehensive immune profiling using flow cytometry, including signaling pathway characterization, xenograft-derived cell processing, and functional assays such as cytotoxicity, proliferation, activation, and survival assays.
Associate Principal Scientist, Immunology Discovery Merck & Co IncAssociate Principal Scientist, Immunology DiscoverySan Diego, CA$142,400–$224,100 / yearKey Responsibilities: Define and drive drug discovery immunology project/program strategies and collaborate effectively with colleagues within Discovery Immunology and across other functional areas (i.e. Discovery Biologics, Quantitative Biosciences, Pharmacokinetics, Dynamics, Metabolism and Bioanalytics) to achieve organizational objectives. Preferred Experience and Skills: Experience leading cross-functional biologics or chemistry discovery programs for Gastroenterology, Dermatology, and/or Rheumatology, especially autoimmune or immune-mediated disorders, including in both large and small pharma contexts.
Senior Principal Scientist, Computational Multiomics, Precision Measures Johnson and JohnsonSenior Principal Scientist, Computational Multiomics, Precision MeasuresSan Diego, CAFull timePartner with Neuroscience Discovery on the evaluation of target opportunities from the perspective of cutting-edge genetics, bioinformatics, biosignatures, brain biology, and mechanism, drawing upon a combination of internal and external human data resources and integrative analytics. We are searching for a Senior Principal Scientist, Computational Multiomics, Precision Measures, to be in either Cambridge, MA; Spring House, PA; La Jolla, CA United States of America or Beerse, Antwerp, Belgium, and follows a hybrid schedule of three days in the office and two days remotely per week.
Principal Environmental Scientist (Natural Resources) Project Resource CollectivePrincipal Environmental Scientist (Natural Resources)San Diego, CaliforniaCollaborating with internal subject matter experts (biologists, archaeologists, GIS specialists, planners, regulatory specialists, and engineers) and external technical partners, protection agencies, and state or federal lead agencies. Experience leading projects/programs and working in dynamic, collaborative environments that require flexibility in assuming new roles and changing project directions.
Scientist – Preclinical Team Capricor TherapeuticsScientist – Preclinical TeamSan Diego, CaliforniaCapricor Therapeutics does not accept candidate submissions or referrals from recruiting agencies, staffing firms, or third-party recruiters without express written approval from Talent Acquisition and a fully executed agreement with Capricor. We are seeking a Science to join our Pre-Clinical team to support the progression of our therapeutic programs through the design, execution, and optimization of in vivo research activities and preclinical studies.
Principal Scientist, Assay Development Allen SpoldenPrincipal Scientist, Assay DevelopmentSan Diego, CaliforniaLead assay teams on a projects, contribute to core teams, and work with cross -functional teams to deliver the best -in -class reagents and software. The successful candidate will love doing good science in the laboratory with a great group of scientists as well as analyzing a lot of data with a strong focus on the customer experience.
Principal Scientist, Pharmaceutical Development Neurocrine Biosciences IncPrincipal Scientist, Pharmaceutical DevelopmentSan Diego, CA$130,800–$179,000 / yearThe company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in patients with Prader-Willi syndrome, endometriosis and uterine fibroids , as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. Collaborate cross-functionally with internal teams (e.g., Discovery, Chemical Development, Analytical, Clinical, Regulatory, Quality, and Supply Chain) to advance programs and ensure effective knowledge transfer across development stages.
Senior Principal Scientist, Neuroscience, Clinical Biomarker, Late Phases, Translational Medicine Bristol-Myers Squibb CoSenior Principal Scientist, Neuroscience, Clinical Biomarker, Late Phases, Translational MedicineSan Diego, CA$184,060–$223,036 / yearBased on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day. Key Responsibilities: Designs and implements program-specific late development biomarker/translational plans, responsible for aiding in creation of clinical protocols, SAPs, SOWs, lab manual, and interfacing with CRO for execution of services, in conjunction with Biospecimen Operations and Procurement.
Principal Scientist, Medicinal Chemistry Neurocrine Biosciences IncPrincipal Scientist, Medicinal ChemistrySan Diego, CA$130,800–$179,000 / yearThe company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in patients with Prader-Willi syndrome, endometriosis and uterine fibroids , as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. Your Contributions (include, but are not limited to): Leads projects and initiatives in the rapid optimization of lead molecules utilizing modern technology available to medicinal chemists such as automated synthesis and purification.
Principal Scientist, Analytical Development Neurocrine Biosciences IncPrincipal Scientist, Analytical DevelopmentSan Diego, CA$130,800–$179,000 / yearThe company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in patients with Prader-Willi syndrome, endometriosis and uterine fibroids , as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. About the Role: Responsible for leading analytical development activities for multiple projects to support drug substance development from preclinical through commercial phase, with a focus on small molecules.
Senior Scientist / Principal Scientist - Process Chemistry Treeline Biosciences IncSenior Scientist / Principal Scientist - Process ChemistrySan Diego, CA$166,380–$189,533 / yearThe successful candidate will collaborate with cross-functional teams, including Medicinal Chemistry, DMPK, Toxicology, Drug Product, and Analytical Sciences to develop practical routes that support SAR exploration and deliver material for biological and early toxicology studies. Treeline Biosciences, a clinical-stage biotechnology company advancing precision medicines, is seeking an experiencedsmall molecule process chemistto drive the development, scale-up, andcommercialreadiness of oursmallmolecule, clinical-stageportfolio.
Principal Scientist, Medicinal Chemistry Iambic TherapeuticsPrincipal Scientist, Medicinal ChemistrySan Diego, CaliforniaThe ideal candidate will be passionate about solving medicinal chemistry challenges, as well as proactively interfacing with diverse teams working on automated experimentation, AI-driven molecular generation, property predictions, and bioassay data generation. Execute on high quality ideas by employing a broad range of modern organic chemistry transformations, synthetic methods, creative use of parallel experimentations and implementing innovative techniques.
NewSenior Principal Scientist: Metabolomics/Cell Therapy Media Development GenentechSenior Principal Scientist: Metabolomics/Cell Therapy Media DevelopmentSan Diego, CaliforniaAs a member of this team, you will lead cutting-edge efforts to develop and optimize cell culture media platforms while collaborating closely with key stakeholders across Analytical Development, Research, Manufacturing Operations, and cross-functional teams within Genentech and Roche. Strategic technical leadership: Proven track record of leading complex technical projects from conception to completion with strong organizational skills and scientific rigor; demonstrated ability to translate research insights into practical manufacturing solutions.
Principal Research Scientist II Lipid Chemistry AbbVie IncPrincipal Research Scientist II Lipid ChemistrySan Diego, CAIndependently lead research efforts through deep technical understanding and work collaboratively within a cross-functional product development team to drive design, functional screening, development and production of novel tLNP formulations for targeted, extra hepatic delivery of nucleic acid payloads. Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position.