Postdoctoral Fellow-MSH-30020-176

Description

In response to this challenge, Additional Ventures - a nonprofit organization dedicated to funding transformative research in single ventricle heart disease - has established the Additional Ventures Cures Collaborative (AVCC), an ambitious, multi-institutional, and deeply interdisciplinary consortium with the explicit goal of developing curative therapies for patient living with single ventricle disease.

https://www.additionalventures.org/initiatives/biomedical-research/cures-collaborative/

The AVCC brings together leading investigators across cardiac developmental biology, bioengineering, regenerative medicine, stem cell biology, computational modeling, and clinical cardiology, creating a uniquely integrated research environment that bridges the full spectrum from fundamental science to translational application. The Dubois Laboratory is a proud member of this collaborative, embedded within a rapidly expanding and highly connected community of single ventricle researchers who share data, tools, and insights across institutional boundaries. This position offers an exceptional opportunity to conduct research at the heart of this effort, with direct access to the collaborative's scientific network, resources, and translational momentum.

About the Dubois Laboratory

The Dubois Laboratory investigates the fundamental mechanisms governing cardiac development, with particular focus on ventricular chamber morphogenesis, cardiomyocyte specification and maturation, and the developmental origins of congenital heart disease. We combine mouse genetics, human pluripotent stem cell models, single-cell and spatial transcriptomics, and functional assays to understand how the heart is built and how that process is compromised in disease. Our work is deeply integrated with the AVCC's mission, and the successful candidate will work at the intersection of developmental biology, stem cell science, and cardiac bioengineering to advance a transformative therapeutic strategy for single ventricle disease. https://labs.icahn.mssm.edu/duboislab/

Responsibilities

Position Overview

The Dubois Laboratory is recruiting a highly motivated Postdoctoral Fellow to lead a research program focused on the generation of highly functional, mature cardiomyocytes and their application toward building a pulsatile cardiac conduit as a potential therapy for single ventricle heart disease. This is a scientifically ambitious and technically multidisciplinary project that will require expertise spanning stem cell biology, cardiac differentiation, tissue engineering, and functional cardiac physiology. The successful candidate will have a central and intellectually independent role in shaping and executing this research, working in close collaboration with

AVCC partners across institutions and disciplines. We are looking for an individual who combines scientific rigor and creativity with the drive to work both independently and as a fully engaged member of a collaborative team. This position is ideally suited to a researcher who is motivated by the prospect of developing work that could ultimately benefit patients.

Key Responsibilities

• Lead the design and execution of research projects aimed at generating highly functional

and mature cardiomyocytes from human pluripotent stem cells (hiPSCs) for therapeutic

applications in single ventricle disease

• Develop and optimize protocols for cardiomyocyte maturation, including metabolic,

electrical, mechanical, and structural maturation endpoints

• Collaborate with AVCC bioengineering partners on the integration of mature

cardiomyocytes into pulsatile conduit constructs, contributing biological expertise to an

interdisciplinary design process

• Apply advanced functional assays to characterize cardiomyocyte maturity and

performance, including electrophysiology, calcium imaging, contractile force

measurements, and metabolic profiling

• Leverage single-cell and spatial transcriptomic tools to interrogate cardiomyocyte

identity, maturation state, and functional heterogeneity

• Participate actively in AVCC collaborative meetings, contribute to cross-institutional data

sharing, and help build the broader single ventricle research community

• Mentor junior laboratory members including graduate students and research technicians
• Contribute to the preparation

Qualifications

Qualifications

Required

• PhD, MD/PhD, or equivalent doctoral degree in cell biology, developmental biology,

biomedical engineering, physiology, or a closely related field

• Demonstrated expertise in human pluripotent stem cell culture and directed cardiac

differentiation

• Strong publication record commensurate with experience, with evidence of independent

scientific thinking and productivity

• Solid foundation in cell and molecular biology techniques
• Excellent written and oral communication skills, including experience presenting in

scientific forums

• Ability to work independently and collaboratively in a multidisciplinary research

environment

• Enthusiasm for translational research and a genuine interest in the clinical problem of

single ventricle heart disease

Preferred

• Experience with cardiomyocyte maturation strategies and functional characterization

(electrophysiology, contractility, calcium handling, metabolomics)

• Familiarity with cardiac tissue engineering technologies
• Experience with single-cell RNA sequencing, spatial transcriptomics, or other highdimensional

genomic approaches

• Background in cardiac development, congenital heart disease, or cardiovascular

physiology

• Prior experience in a collaborative, multi-institutional research environment
• Experience mentoring junior researchers

What We Offer

• A scientifically ambitious and clinically motivated research program with real potential for

therapeutic impact

• Integration into the Additional Ventures Cures Collaborative and its expanding network

of world-leading single ventricle researchers

• Access to state-of-the-art facilities at one of the world's premier biomedical research

institutions

• A highly interdisciplinary environment spanning developmental biology, stem cell

science, bioengineering, and clinical cardiology

• Dedicated mentorship supporting the development of an independent scientific career
• Competitive salary and benefits commensurate with experience and qualifications

How to Apply

Interested candidates should submit the following materials in a single email to:

nicole.dubois@mssm.edu

• A current curriculum vitae (CV) including a full list of publications
• A brief letter of intent (1-2 pages) describing your research experience, relevant

expertise, your specific interest in this position, and your longer-term scientific goals

• Contact information for three references
• Review of applications will begin immediately and will continue until the

Employer Description

Strength through Unity and Inclusion

The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai's unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.

At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history.

About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time - discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients' medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report's "Best Children's Hospitals" ranks Mount Sinai Kravis Children's Hospital among the country's best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek's "The World's Best Smart Hospitals" ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

Equal Opportunity Employer

The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.

Compensation

The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.