Research Associate Discovery Chemistry

Job Title: Research Associate – Discovery Chemistry
Location: 1 DNA Way, South San Francisco, CA 94080
Pay Rate: $27.25 – $35.38/hour + Benefits
Contract Duration: 12 Months (Potential for Extension)
Work Schedule: Full-Time, 40 Hours per Week
Benefits: Weekly Pay, Medical, Dental, and Vision Insurance

Position Overview
We are seeking a motivated and detail-oriented Research Associate to join the Discovery Chemistry Group at Genentech. This role will focus on supporting small-molecule drug discovery through the purification of small molecules, short peptides, macrocycles, and other chemical compounds, primarily using preparative High-Performance Liquid Chromatography (HPLC).
The successful candidate will work closely with chemists and research teams to develop and optimize HPLC methods, analyze and interpret experimental data, troubleshoot instrument and method-related issues, and present findings during team meetings.
This position offers an opportunity to work with advanced laboratory technologies, including HPLC, LC-MS, and automated purification equipment, while contributing to innovative drug discovery research. The ideal candidate will thrive in a collaborative, fast-paced environment and demonstrate strong analytical, technical, and problem-solving abilities.
Key Responsibilities

• Perform purification of small molecules, short peptides, macrocycles, and other compounds using preparative HPLC techniques.
• Develop, optimize, and implement HPLC purification methods to support drug discovery projects.
• Analyze, interpret, and summarize experimental and chromatographic data.
• Troubleshoot HPLC instruments, purification methods, and related laboratory equipment.
• Collaborate with chemists and cross-functional research teams to support ongoing projects.
• Present experimental results, findings, and project updates during group meetings.
• Utilize advanced laboratory technologies, including HPLC, LC-MS, and automated purification systems.
• Stay current with emerging purification methods, technologies, and industry best practices.
• Contribute to team objectives through innovation, teamwork, and creative problem-solving.

Required Qualifications

• Bachelor's or Master's degree in Chemistry, Biochemistry, or a related scientific discipline.
• Strong theoretical understanding of organic and analytical chemistry.
• Hands-on experience with chromatography techniques, including:
  • Reverse-Phase (RP) Chromatography
  • Normal-Phase (NP) Chromatography
  • Ion-Exchange Chromatography (IEX)
  • Solid-Phase Extraction (SPE)
• Experience with analytical techniques such as Mass Spectrometry (MS) and Nuclear Magnetic Resonance (NMR).
• Ability to work effectively in a fast-paced research environment while managing multiple priorities.
• Strong organizational skills, attention to detail, and effective time management.
• Ability to work independently and collaboratively within a team.
• Excellent verbal and written communication, interpersonal, and problem-solving skills.

Benefits Offered Through Tailored Management
At Tailored Management, we take pride in connecting talented professionals with meaningful career opportunities. We are committed to supporting our employees through comprehensive benefits designed to promote their health, well-being, and financial security.
Available benefits include:

• Medical Insurance – HDHP, PPO, and Surest plan options
• Minimum Essential Coverage (MEC)
• Dental and Vision Insurance
• Short-Term Disability (STD)
• Long-Term Disability (LTD)
• Life and Accidental Death & Dismemberment (AD&D) Insurance
• Critical Illness Insurance
• Accident Insurance
• Employee Assistance Program (EAP)

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