Medicilon USA Corp is seeking a motivated and detail-oriented Research Associate to join our DMPK and Bioanalysis team in Lexington, MA. This is a hands-on laboratory role supporting preclinical drug discovery and development, with a primary focus on bioanalytical sample preparation, LC-MS/MS, and quantitative analysis.
The ideal candidate will have practical experience in analytical chemistry, bioanalysis, or DMPK, with a strong understanding of laboratory techniques and biological sample processing. This individual will work closely with Scientists and cross-functional teams to support pharmacokinetic (PK), toxicokinetic (TK), pharmacodynamic (PD), biomarker, and biodistribution studies across multiple therapeutic modalities.
Key Responsibilities
Perform bioanalytical sample preparation and quantitative analysis of biological matrices, including plasma, serum, urine, and tissue samples.
Support LC-MS/MS method development, optimization, and analysis of small molecules, biologics, oligonucleotides, and other therapeutic modalities.
Perform sample preparation techniques, including protein precipitation, liquid-liquid extraction, and solid-phase extraction (SPE).
Prepare calibration standards, quality control samples, reagents, and study samples.
Operate, maintain, and troubleshoot LC-MS/MS, HPLC, and other analytical laboratory instruments.
Process, analyze, and summarize experimental data using Analyst, Excel, GraphPad Prism, or other relevant software.
Support bioanalytical studies for PK, TK, PD, biomarkers, and biodistribution.
Assist with additional bioanalytical platforms, including ELISA/MSD, ligand-binding assays, qPCR/ddPCR, and cell-based assays, as needed.
Support in vitro ADME assays, including metabolic stability, plasma protein binding, permeability, and drug-drug interaction (DDI) studies.
Maintain accurate laboratory records and documentation in accordance with established SOPs, study protocols, and applicable GLP/GxP requirements.
Assist with data interpretation, study reports, and technical documentation.
Collaborate with Scientists and project teams to ensure accurate, efficient, and timely study execution.
Qualifications
Bachelor's or Master's degree in Analytical Chemistry, Chemistry, Biochemistry, Pharmaceutical Sciences, Pharmacology, Biology, or a related field.
1–3 years of relevant laboratory experience in bioanalysis, analytical chemistry, DMPK, pharmaceutical research, or a related field.
Hands-on experience with LC-MS/MS and/or HPLC instrumentation.
Experience with biological sample preparation and processing, including plasma, serum, urine, or tissue samples.
Understanding of chromatographic techniques, mass spectrometry, and quantitative bioanalytical methods.
Familiarity with laboratory data analysis, documentation, and quality control procedures.
Strong attention to detail, organizational skills, and ability to follow established experimental protocols and SOPs.
Good communication, problem-solving, and teamwork skills.
Ability to work independently on assigned laboratory tasks while collaborating effectively with a multidisciplinary team.
Preferred Qualifications
Previous experience in a CRO, pharmaceutical, or biotechnology laboratory environment.
Experience with LC-MS/MS method development, optimization, qualification, or validation.
Experience with bioanalysis of small molecules, oligonucleotides, biologics, or other novel therapeutic modalities.
Familiarity with ELISA/MSD, ligand-binding assays, qPCR/ddPCR, or cell-based assays.
Knowledge of GLP principles and FDA/EMA bioanalytical method validation guidelines.
Experience with in vitro ADME assays or PK data analysis using Phoenix WinNonlin.
Hands-on experience supporting in vivo rodent studies, including animal handling, compound dosing, blood collection, necropsy, and tissue harvesting.
Experience processing biological samples collected from in vivo studies for downstream bioanalytical analysis.
Numbers & Facts
Location
Lexington, MA
Job Type
Full-time
Skills
Analysis Skillsunmatched
Analytical Chemistryunmatched
Assaysunmatched
Biochemistryunmatched
Biologyunmatched
Biomarkersunmatched
Biotech and Pharmaceuticalunmatched
Blood Bankunmatched
Calibrationunmatched
Chromatographyunmatched
Clinical Researchunmatched
Communication Skillsunmatched
Contract Research Organization (CRO)unmatched
Cross-Functionalunmatched
Data Analysisunmatched
Dental Insuranceunmatched
Detail Orientedunmatched
Documentationunmatched
Droplet Digital PCR (ddPCR)unmatched
Drug Developmentunmatched
Drug Discoveryunmatched
Drug Interactionsunmatched
FDA (Food and Drug Administration)unmatched
GLP (Good Laboratory Practices)unmatched
Health Insuranceunmatched
High Performance Liquid Chromatography (HPLC)unmatched