Research Associate II, High-Throughput Screening

Position Title: Research Associate II, High-Throughput Screening

Reports To: Director, Platform

Location: Watertown, MA

Join the adventure!

CAMP4 Therapeutics is leveraging a proprietary RAP platform to discover antisense oligonucleotide (ASO) therapeutics targeting regulatory RNAs (regRNAs) to treat a broad range of CNS diseases. We are seeking a motivated Research Associate II to join our high-throughput screening team to help identify, characterize, and optimize novel ASO therapeutics.

The successful candidate will execute, optimize, and automate existing in vitro screening workflows, culture relevant cell models, generate high-quality molecular data, and collaborate with Discovery, Chemistry, and Data Science colleagues. This role is ideal for a hands-on scientist who combines careful experimental execution with strong organization, curiosity, creativity, and teamwork.

Key Responsibilities:

• Plan and execute high-throughput in vitro screens supporting Platform and Discovery efforts to identify ASO candidates that modulate expression of disease-relevant genes
• Operate liquid-handling platforms and associated laboratory automation with a strong focus on accuracy, reproducibility, and throughput
• Culture, maintain, and experimentally manipulate immortalized, primary, and iPSC-derived cell models
• Perform molecular assays, including RNA isolation, quantitative PCR, digital PCR (dPCR), and protein-based readouts
• Analyze screening data, assess assay quality, identify trends, and communicate results to cross-functional project teams
• Develop, optimize, qualify, troubleshoot, and transfer screening assays, workflows, protocols, and data quality controls to drive improvements in efficiency and capabilities
• Collaborate with Platform, Discovery, Chemistry, and Data Science teams to manage screening priorities and advance hits through validation and characterization
• Maintain detailed and accurate records of experimental designs and results, protocols, sample inventories, and data files
• Support routine laboratory operations, including reagent and supply ordering and preparation, equipment maintenance, and general laboratory upkeep
• Demonstrate a strong work ethic by taking initiative, operating with urgency, and collaborating effectively to advance the discovery of breakthrough medicines for patients

Qualifications:

Education & Experience

• BS or MS degree in molecular biology, biochemistry, cell biology, bioengineering, or related discipline
• Relevant research experience in an industry or academic setting (3+ years with BS degree or 1+ year with MS degree); biotechnology or pharmaceutical industry experience is preferred

Skills & Competencies

• Extensive hands-on experience with mammalian cell culture and cell-based assays
• Experience with basic molecular biology techniques including RNA isolation, quantitative PCR, and western blotting
• Demonstrated ability to execute experiments carefully, document work thoroughly, and deliver reproducible results
• Experience with liquid-handling automation and high-throughput screening is strongly preferred
• Experience with primary cells, differentiated iPSC-derived cells, dPCR, and ASOs, or other oligonucleotide therapeutics is a plus
• Experience with functional genomics or CRISPR-based screening is a plus
• Working proficiency with Microsoft Office, GraphPad, R, or a similar software
• Flexibility and comfort wearing multiple hats and executing on multiple projects in parallel
• Attention to detail, high professional integrity, commitment to excellence in execution, and capability of managing tasks and projects independently
• Clear written and verbal communication skills and the ability to present data to multidisciplinary audiences
• Collaborative, creative, adaptable, and self-motivated, with a commitment to scientific rigor and high-quality execution

Compensation and Benefits:

At CAMP4 Therapeutics, we offer a competitive and thoughtfully designed total rewards program. The anticipated salary range for this role is $85,000 - $110,000. Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity. In addition to base salary, employees are eligible to receive an annual bonus and equity incentive opportunities.

Our benefits include medical, dental, and vision insurance; life and disability coverage; paid parental leave; a 401(k) plan with company contribution; Employee Stock Purchase Program, Trek Time (flexible time off); tuition assistance; and additional perks that support your well-being and professional growth.

About CAMP4:

CAMP4 is developing disease-modifying treatments for a broad range of genetic diseases where amplifying healthy protein may offer therapeutic benefits. Our approach amplifies mRNA by harnessing a fundamental mechanism of how genes are controlled. To amplify mRNA, our therapeutic ASO drug candidates target regulatory RNAs (regRNAs), which act locally on transcription factors and are the master regulators of gene expression. CAMP4's proprietary RAPTM Platform enables the mapping of regRNAs and design of optimal chemistry to generate potent therapeutic candidates to address hundreds of genetic diseases across multiple tissues. Learn more about us at www.camp4tx.com and follow us @CAMP4tx.