Research Biologist

Pay Range: $52.28hr - $57.28hr

Job Overview:

The Cardiometabolic Renal Therapeutic Area (CMR) of the organization focuses on the Client of biologic, small molecule and genetic therapeutics for the treatment of diabetes, obesity and associated complications. Our client is seeking a skilled and motivated individual who can contribute to a successful drug Client and development team in the Obesity research group in Cambridge. The successful candidate will leverage their strong in vivo pharmacology background and complementary laboratory skills to play a critical role in supporting Client efforts and established pipeline projects with an emphasis on anti-obesity therapeutics. The successful candidate will be responsible for executing critical capabilities in the laboratory setting and working with other scientists within and across departments to achieve project and department goals.

Key responsibilities include:

• Plan and independently execute in vivo experiments to support preclinical characterization and evaluation of targets/pathways that regulate energy balance.
• Perform routine rodent handling, dosing via multiple routes of administration (including but not limited to PO, IP, SQ, IV), blood collection (including cardiac puncture), perfusion, and tissue collection.
• Conduct metabolic assessments, including food intake measurements, glucose tolerance tests (GTT), and insulin tolerance tests (ITT).
• Perform molecular and biochemical assessments on ex vivo samples.
• Function independently while working within a team-oriented lab environment and cross-functional project teams.
• Maintain accurate records, independently analyze data, and report data in written and oral formats. Perform all work in full compliance with Research Policies and complete all required training activities in the timeframe specified.
• Conduct experiments to identify and validate drug targets.
• Support assay design, optimization, validation, and data analyses.
• Design and execute molecular and cell biology experiments.
• Troubleshoot and analyze complex data in support of drug Client projects.
• Presentation of results and conclusions both orally and written.

Minimum qualifications:

• B.S. and/or M.S. in biology or a closely related field with 3+ years of laboratory experience.

Additional Skills/Preferences:

• A background in the biology and physiology of energy balance regulation and metabolic disease is a plus.
• Experience with immunohistochemistry, brain sectioning, and confocal or fluorescence microscopy imaging is a plus.
• Demonstrated ability to work on cross-functional teams and projects.
• Strong communication skills and experience presenting data in a team environment.