Research Fellow - Cancer Biology

Site: Massachusetts Eye and Ear Infirmary

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

Job Summary

Will conduct independent and collaborative research, contributing to the advancement of knowledge and the development of innovative solutions. The fellow will work under the supervision of the Principal Investigator and collaborate with a team of researchers.

Does this position require Patient Care?

No

Essential Functions

• Design, plan, and execute research experiments or projects in alignment with departmental goals.
• Gather, analyze, and interpret data using appropriate statistical methods and tools.
• Conduct comprehensive literature reviews to inform research direction and methodologies.
• Prepare and publish research findings in peer-reviewed journals and present at conferences and seminars.
• Work collaboratively with faculty, students, and other researchers, contributing to a positive research environment.
• Mentor graduate and undergraduate students, providing guidance on research methodologies and techniques.
• Assist in the preparation of grant proposals and funding applications to support ongoing research.
• Prepare periodic reports and documents summarizing research progress and outcomes.

Qualifications

Education

Doctorate Related Field of Study required

Can this role accept experience in lieu of a degree?

No

Licenses and Credentials

Experience

Previous Research experience 3-5 years required

Knowledge, Skills and Abilities

• Demonstrated experience in research techniques, methods, or research areas relevant to the project.
• Proficient analytical skills, proficiency in statistical software, and excellent written and verbal communication skills.
• Ability to work independently as well as collaboratively within a team.
• Good interpersonal and communication skills.

Salary: $70,000.00 - $71,750.00/Annual

Additional Job Details (if applicable)

Qualifications: PhD in molecular biology, Biochemistry, biophysics, immunology, or related field strongly preferred.

The ideal candidate will have demonstrated hands-on experience with animal models and/or a strong background in cell culture and molecular biology techniques, including tissue handling, mammalian cell culture, and standard biochemical assays. Preferred qualifications include prior experience with xenograft and orthotopic murine tumor models, cancer biology research, as well as familiarity with molecular biology techniques such as Western blotting, nucleic acid extraction, single-cell RNA sequencing, spatial biology, flow cytometry, immunofluorescence, and immunohistochemistry. Exposure to biomedical imaging, quantitative assays, or interdisciplinary research environments integrating biology and technology is desirable. Strong proficiency in following experimental protocols with precision, maintaining accurate records, and working with biological samples is essential.

In vivo mouse tumor models

• Establishing, maintaining, and monitoring orthotopic and xenograft murine tumor models
• Subcutaneous, IP, and IV injections
• Handling and processing of mouse tissues following in vivo experiments
• Supporting ex vivo tissue preparation and analysis, including sample preservation for downstream assays

Cell biology and in vitro systems

• Maintaining routine 2D and 3D mammalian cell culture
• Establishing and expanding primary cell lines from tumor or tissue specimens
• Performing cell-based assays to evaluate biological responses to therapeutic or imaging agents
• Supporting experimental design and execution of mechanistic studies in vitro

Molecular and biochemical techniques

• Tissue processing for downstream molecular analyses
• Extraction of DNA, RNA, and proteins from tissue and cell samples
• Western blotting, immunodetection, and related protein analysis techniques
• Flow cytometry and sample preparation for immune and tumor cell profiling
• Supporting downstream data interpretation in collaboration with investigators

Remote Type

Onsite

Work Location

20 Staniford Street

Scheduled Weekly Hours

40

Employee Type

Regular

Work Shift

Day (United States of America)

EEO Statement:

5110 Massachusetts Eye and Ear Infirmary is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.

Mass General Brigham Competency Framework

At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.