Scientist II - LNP Formulation

Hot Job

Scientist II - LNP Formulation

Apollo Professional Solutions

San Diego, CA 92111

$40 - $50/hour

Posted 10/13/2026

Job ID: 77689

Job Description

Scientist II - LNP Formulation

Location: San Diego, CA (Onsite)

Relocation Assistance: Not Available

Help Advance the Future of Nucleic Acid Delivery

We are seeking a talented and highly motivated Scientist II - LNP Formulation to join an innovative formulation development team focused on advancing non-viral delivery technologies. This hands-on laboratory role is ideal for scientists with experience in lipid nanoparticle (LNP) formulation, nucleic acid delivery, and formulation development who are eager to contribute to cutting-edge therapeutic programs.

Working alongside experienced formulation scientists, you will support the development, optimization, and characterization of both targeted and non-targeted lipid nanoparticles for in vitro and in vivo applications.

Key Responsibilities Lipid Nanoparticle Formulation & Development

• Formulate and optimize lipid nanoparticles (LNPs) and targeted lipid nanoparticles (tLNPs) for the delivery of nucleic acids, including mRNA, siRNA, and DNA.
• Execute formulation activities with guidance from senior scientists to support preclinical research programs.
• Design and conduct experiments to improve nanoparticle performance, encapsulation efficiency, and overall formulation robustness.
• Support early-stage formulation development activities and process optimization efforts.

Experimental Design & Characterization

• Implement Design of Experiments (DoE) strategies to evaluate formulation variables and identify optimal LNP compositions and manufacturing parameters.
• Perform and interpret LNP characterization studies using techniques such as:
• Dynamic Light Scattering (DLS)
• Zeta Potential Analysis
• Ribogreen Assays

Analyze formulation performance data and generate actionable insights to guide development decisions. Cross-Functional Collaboration

• Partner with research, analytical, and development teams to support formulation requests and project objectives.
• Contribute technical expertise to ongoing development programs and provide formulation support across multiple initiatives.
• Present experimental findings, recommendations, and project updates to team members and leadership.

Scale-Up & Process Support

• Assist with downstream processing and formulation activities, including:
• Cryoprotection studies
• Stability assessments
• Process scale-up initiatives

Support efforts to improve formulation reproducibility and manufacturability. Documentation & Laboratory Operations

• Maintain accurate, organized, and detailed laboratory records documenting experiments, observations, and results.
• Ensure data integrity and compliance with laboratory documentation standards.
• Participate in routine laboratory operations, including:
• Inventory management
• Supply ordering
• Buffer preparation
• Equipment maintenance and autoclaving activities

Qualifications Required

• Bachelors degree in Chemistry, Biochemistry, Chemical Engineering, Pharmaceutical Sciences, or a related scientific discipline with 5+ years of biopharmaceutical industry experience, OR
• Masters degree in a related field with 2+ years of industry experience.
• Minimum 2 years of hands-on experience in lipid nanoparticle (LNP) formulation and nucleic acid encapsulation.
• Direct experience working with nucleic acid payloads such as mRNA, siRNA, or DNA.
• Strong knowledge of LNP characterization methodologies, including DLS, Zeta Potential, and Ribogreen assays.
• Advanced proficiency with Microsoft Excel for data analysis and reporting.
• Exceptional attention to detail with a demonstrated record of generating high-quality, reproducible experimental data.
• Strong organizational, communication, and collaboration skills in a fast-paced research environment.

Preferred

• Experience with statistical analysis and visualization software such as JMP and GraphPad Prism.
• Hands-on experience developing targeted lipid nanoparticles (tLNPs), including:
• Monoclonal antibody (mAb)-coated LNPs
• Fab-coated LNPs
• ScFv-coated LNPs
• VHH-coated LNPs

Experience supporting immune cell-targeted delivery applications. Knowledge of formulation scale-up and stability assessment workflows. Why Join This Opportunity?

• Contribute to innovative LNP and nucleic acid delivery technologies.
• Work on impactful research programs supporting next-generation therapeutics.
• Gain exposure to advanced formulation development, characterization, and scale-up activities.
• Collaborate with a highly skilled, cross-functional scientific team in a fast-paced biopharmaceutical environment.

Position Type: Contract

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About San Diego, CA

Ready to embark on an exciting career journey in sunny Southern California? Explore our job opportunities in the thriving city of San Diego! Known for its stunning beaches, perfect weather, and vibrant culture, San Diego offers a unique combination of career growth and quality of life. With renowned attractions like Balboa Park, the San Diego Zoo, and the USS Midway Museum, along with a diverse culinary scene and a plethora of art galleries and theaters like the La Jolla Playhouse, theres always something new to experience. Whether youre a sports enthusiast looking to cheer for the Padres at Petco Park or seeking outdoor adventures at Torrey Pines State Natural Reserve, San Diego has something for everyone. Begin your job search today and discover why this picturesque city is the perfect place to elevate your career!

Salary Notes: The compensation listed reflects the good-faith rate currently anticipated for this position and may be adjusted, where permitted by law, based on business needs, applicable qualifications and experience.

EEO Statement: Apollo Professional Solutions, Inc. is an equal opportunity employer. We provide equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, marital status, age, national origin, ancestry, disability status, medical condition, pregnancy, genetic information, protected veteran status, gender, sexual orientation, gender identity or expression, or any other status or characteristic protected under federal, state, or local law.

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