Senior Director, Clinical Operations

Location: Boston/Cambridge, MA, USA - Hybrid (minimum 2-3 days per week onsite)

Reporting to: SVP Clinical Operations

About Hemab

Hemab is building preventative treatments for serious, underserved bleeding disorders. These are therapies designed to work with the bodys own biology and stop bleeds before they start, instead of treating them after they happen. Were patient-first, science-led and clinical-stage - with a pipeline that takes different scientific approaches to different patient needs.

We went public via our 2026 IPO, and were scaling across two homes: Cambridge, MA, USA, and Copenhagen, Denmark.

The role

As Senior Director, Clinical Operations, youll lead operational strategy and execution for one of our programs (either HMB-002 or HMB-003), from early development through pivotal trials. Youll own the delivery of complex global studies, anticipate what could put the program at risk, and make sound decisions when the path forward isnt straightforward.

This is a clinical leadership role with genuine accountability. Youll shape development plans alongside scientific and medical colleagues, lead teams and external partners, and build the structure needed to deliver without losing speed.

What youll do

• Own end-to-end clinical operations strategy and delivery for one of the assigned assets (either HMB-002 or HMB-003), ensuring studies meet critical milestones, quality expectations and budget commitments.
• Translate development strategy into executable plans, using critical-path analysis, scenario planning and early risk identification to protect timelines.
• Take charge when trials encounter difficulties, diagnosing root causes, evaluating options and driving recovery plans through to resolution.
• Represent Clinical Operations on the Asset Team and Clinical Strategy Subteam, challenging assumptions constructively and bringing evidence-based recommendations to development decisions.
• Lead global site activation, recruitment and enrollment strategies, addressing feasibility and patient-access challenges before they affect delivery.
• Hold CROs and external partners accountable for performance, budgets, forecasts, change orders and agreed deliverables.
• Build practical frameworks for governance, decision-making, reporting and trial oversight, maintaining ICH-GCP compliance and inspection readiness.
• Lead and develop Clinical Operations colleagues, strengthen cross-functional accountability and communicate program risks and recommendations clearly to executive leadership and the Board.

What youll bring to Hemab

• Substantial clinical operations leadership experience in biotechnology or pharmaceuticals, with accountability for complex global development programs.
• Demonstrated ownership of clinical programs across early and late development, including pivotal studies and challenging enrollment environments.
• Evidence of recovering underperforming trials through sound judgment, scenario planning and decisive execution.
• Strong command of ICH-GCP, global regulatory requirements, clinical trial budgets and CRO performance management.
• Experience leading and developing teams through changing priorities, with the ability to influence senior stakeholders and challenge decisions constructively.
• Ability to move between asset-level strategy and hands-on execution, knowing when to decide, collaborate or escalate.

Nice to have

• Experience in rare diseases, hematology or bleeding disorders, particularly von Willebrand disease, hemophilia or Glanzmann thrombasthenia.
• Experience contributing to BLA/MAA submissions or implementing clinical technologies and innovative trial models.

What to expect, honestly

Hemab is still building a lot of its own structure. Systems here tend to get created as we need them, not handed down in advance. Whoever takes this role will likely build some of their own process instead of inheriting a finished one. We work across two hubs and multiple time zones - bridging that well takes real, deliberate effort. And because were growing quickly, priorities can shift with less notice than they would at a larger, more established company.

Were still defining parts of our governance, responsibilities and ways of working. Youll help establish what works, sometimes without a complete team or established infrastructure. Youll need to take ownership, ask for help without ego and work across functions and time zones.

At our size, how you work matters as much as your credentials. Good structure should create speed and trust.

Why Hemab

At Hemab, your work ultimately connects back to something simple. People living with serious bleeding disorders get something theyve never had before - the chance to prevent a bleed, instead of reacting to one after it happens. Youll be joining at a stage where individual decisions still carry real weight, and where your work can help turn promising science into a preventative treatment that actually reaches patients.

How we treat our people is meant to be an extension of how we think about patients: with care, honesty, and respect. Were still building the consistency to back that up across every hiring process, every time. Wed say that plainly instead of pretending otherwise. If any part of your experience with us falls short of it, tell us.

Hemab builds balanced candidate slates and assesses everyone against a single standard. If you need a reasonable adjustment at any stage of the hiring process, please tell us.

Equal Employment Opportunity

Hemab Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.