NIH Accelerating Medicines Partnership) on novel computational and experimental approaches + Communicate findings and recommend follow-up actions in multiple settings (including 1:1, seminars, and team meetings) **Basic Qualifications** + Principal Scientist Bachelor's Degree in computational biology, computational genomics/genetics, computer science, statistics, mathematics, or other related discipline 8+ years of academic / industry experience + or Master's Degree in computational biology, computational genomics/genetics, computer science, statistics, mathematics, or other related discipline 6+ years of academic / industry experience + or PhD in computational biology, computational genomics/genetics, computer science, statistics, mathematics, or other related discipline 4+ years of academic / industry experience **Preferred Qualifications** + Advanced hands-on knowledge of at least one high-level programming language such as R or Python for computational research and reproducible research practices + 5+ years of post-graduate experience in computational biology research (biopharma industry preferred) with track record (such as scientific publications) in driving and advancing research projects/programs with computational approaches + Hands on experience analyzing and integrating high-dimensional molecular datasets such as multi-omics (RNA-seq, ATAC-seq, proteomics, ChIP-seq/CUT&RUN ), single cell (CITE-seq, scATAC-seq, perturb-seq) + Hands on experience on spatial profiling (Xenium, Visium, GeoMx, CosMX ) data analyses and interpretation + Experience implementing and/or developing statistical methodologies and machine learning algorithms applied to the biological problems + Background in human disease biology, especially in areas of neurodegenerative disease, cardiovascular diseases and autoimmune diseases strongly preferred + Experience applying computer vision models to cellular imaging data preferred + Experience utilizing and applying AI agent such as claude coding to accelerate workflow preferred + Scientific curiosity with an ability of self-learning + Strong oral and written communication skills If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. **Work-life benefits include:** Paid Time Off + US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) + Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.