Conceive, design, and develop novel technologies addressing some of the most consequential challenges of our time, such as holistic data center co-optimization (computation, energy, water resources, power systems, waste heat recovery), nuclear fusion energy, AI-driven acceleration of AI workloads and quantum computing simulation on HPC systems, and trustworthiness of AI/LLM-based systems. Develop novel methods for high-assurance multi-agent and multi-objective real-time control of complex cyber-physical systems, LLM-enabled explainable decision-making, agentic frameworks, and diffusion-model and inverse-model approaches for design and optimization.