Principal Scientist, Systems And Disease Biology SanofiPrincipal Scientist, Systems And Disease BiologyCambridge, MA$122.25–$176.58 / hourD. in systems biology, computational biology, biostatistics, or related quantitative field with proven experience in a relevant disease area (Immunology, Neurology or Oncology) OR PhD in biological sciences, biomedical sciences, immunology, neuroscience, oncology or in a related disease area and proven advanced track record of data analytics, ML/AI, or computational biology. Leading projects involving internal experiment design and data analytics as well as outsourcing of established workflows and/or complex follow-up mechanistic assays (organoid, CRISPR, proteomics).
Principal Scientist, TCR Optimization ModernaTXPrincipal Scientist, TCR OptimizationCambridge, MassachusettsWe are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. The role is well suited for a hands-on scientist who can execute complex experimental workflows, interpret multi-parameter datasets, and contribute to the generation of optimized TCR candidates with the potency, specificity, and developability required for therapeutic advancement.
Principal Scientist, Computational Protein Design ModernaTXPrincipal Scientist, Computational Protein DesignCambridge, MassachusettsWe are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. This individual will work in close partnership with structural biology, directed evolution, immunology, translational science, and program teams to advance platform innovation and therapeutic programs across Moderna’s Research and Early Development portfolio.
Principal Ai/Ml Researcher WhoopPrincipal Ai/Ml ResearcherBoston, MA$270,000–$300,000 / yearDeep expertise in modern deep learning (transformers, state space models), multimodal training, self-supervised and representation learning, RL-based post-training (PPO/DPO/GRPO), and large-scale distributed training (data, model, and context parallelism). At WHOOP, we view total compensation as the combination of base salary, equity, and benefits, with equity serving as a key differentiator that aligns our employees with the long-term success of the company and allows every member of our corporate team to own part of WHOOP and share in the company's long-term growth and success.
Principal Consultant AppianPrincipal ConsultantBoston, MA$100,000–$225,000 / yearKnowledge of software testing practices (test-driven development, automated test suites within a continuous integration framework); integrations experience using APIs such as REST and SOAP, JDBC connections, and web services; familiarity with Amazon Web Services (AWS), Artificial Intelligence (AI), Analytics, Machine Learning, Google Cloud, Application Integration, Database, Developer Tools, Management & Governance, and Elastic Containers is preferred. This includes working within an agile environment to understand our client's business processes and technical needs, launch new relational data models in production, developing APIs to integrate with multiple systems, partnering with Appian Architects and Technical Delivery Managers, and leading/mentoring consultants through fast-paced software implementations.
Principal Systems Engineer, Digital Lab Systems ModernaTXPrincipal Systems Engineer, Digital Lab SystemsNorwood, MassachusettsWe are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team.
Principal SDET – Linux Kernel Premier Global LinksPrincipal SDET – Linux KernelCambridge, MassachusettsPremier Global Links LLC is seeking an experienced Principal Software Development Engineer in Test SDET to lead test strategy, automation, and system-level validation for a highly distributed, Linux-based AI and compute platform. This is a senior technical leadership opportunity for an engineer who enjoys working at the Linux kernel level, solving complex infrastructure problems, and building scalable automated testing and continuous integration systems.
NewPrincipal FPGA Engineer Ayo SemiconductorPrincipal FPGA EngineerBoston, MassachusettsOur photonic processors will provide orders of magnitude improvement in speed and power efficiency in comparison to conventional digital compute platforms by taking advantage of the natural parallelism, speed and energy efficiency of light. Support the hardware team by performing FPGA trade studies and assessing the viability of proposed pin mappings on developmental circuit card assemblies.
Principal Embedded Software Engineer Lexington Medical, Inc.Principal Embedded Software EngineerBedford, MA$180,000–$220,000 / yearThe embedded software operates under tight real-time, safety-critical constraints, directly driving electromechanical subsystems where milliseconds and failure modes matter, and you will be in the lab working through hardware-software integration issues alongside electrical and mechanical engineers, not just reviewing designs from a distance. This is a hands-on role: you will be building the embedded software for our surgical stapling platform yourself, writing code, integrating drivers, and debugging at the hardware level, while also owning the technical architecture and setting the long-term direction for embedded systems across the platform.
Principal SAP S/4HANA Architect & Lead WayfairPrincipal SAP S/4HANA Architect & LeadBoston, MA$160,225–$176,719 / yearThe SAP Engineering team is responsible for maintaining a highly complex SAP installation used in the Finance department for all General Ledger, Accounts Payable, and Accounts Receivable functions. Experience with high-volume integrations, understanding how SAP interacts with non-SAP systems (Java/Python microservices, cloud-native platforms).
Cyber Engineer Sr. Principal (On-site) HEPCO, Inc.Cyber Engineer Sr. Principal (On-site)Nashua, NH$80–$85 / hourModernize data center networks through spine-leaf architectures, intent-based networking, and high-availability design. This individual must be able to explain complex architectural strategies, demonstrate their business value, and effectively present and defend proposed solutions to technical stakeholders and executive leadership.
BAS Principal - Valuation, Financial Forensics, Litigation (VFL) LitmanGerson AssociatesBAS Principal - Valuation, Financial Forensics, Litigation (VFL)Woburn, MA$140,000–$230,000 / yearFull timespecializing in a given subset Education and Experience:Bachelor's degree in Accountancy, Marketing, Finance, or a related fieldMaster's degree in Accountancy, Marketing, Finance or a plan to pursue preferredOne or more of the following credentials: certified public accountant (CPA), certified valuation analyst (CVA), accredited in business valuation (ABV), chartered financial analyst (CFA), certified business appraiser (CBA), accredited senior appraiser (ASA), certified divorce financial analyst (CDFA) CPA, CVA, ABV, CBA, or ASA certification is required 10+ years' of recent experience in a related field, with a proven ability to lead and develop client relationships. Acts as the firm's preeminent resource in specific technical areasProvides advice and council to clients, partners, and staffManages client expectations, develop solutions, and champions the implementation of client needs and ideasConsistently meets client deadlines timely and adheres to delivering specific client scopesIdentifies and recommends additional services that would be beneficial to clientsProvides exceptional customer service, ensuring client understands services, processes, etc.
Principal Electrical & Compliance Engineer VEIRPrincipal Electrical & Compliance EngineerWoburn, Massachusetts$180,000–$200,000 / yearVEIR’s initial focus is AI data centers behind the meter, with solutions engineered for repeatable deployment through reference designs and integrated controls, designed to incorporate learnings as deployments scale. Own the electrical integration interface designs between VEIR system and datacenter distribution systems, from medium-voltage (MV) switchgear and transformers through low-voltage (LV) switchgear, busway, PDUs, power sidecars, and rack busbars.
Principal Design Quality Engineer I Nova BiomedicalPrincipal Design Quality Engineer IWaltham, MA$120,000–$160,000 / yearNova Biomedical is proud to be a global leader in osmolality testing and biotechnology and in vitro diagnostic (IVD) instrumentation, dedicated to advancing patient care and scientific discovery with a legacy that continues to shape the future of life sciences. With headquarters in Norwood and Waltham, Massachusetts, and a global team of nearly 2,000 employees, we’re building a collaborative, empowered culture grounded in shared values: Customer Centricity, Ingenuity, Ownership & Accountability, Collaboration, and Integrity .
Principal Clinical Content- Physician - Uptodate, Physician Editor, Neurology Wolters KluwerPrincipal Clinical Content- Physician - Uptodate, Physician Editor, NeurologyWaltham, MARemote$173,500–$310,000 / yearUpToDate editors work closely with outside authors, section editors, editors-in-chief, and peer reviewers to ensure the material is accurate and free of bias. In the remaining 10 to 20% time, Physician Editors should continue patient care activities, using their clinical experience to help ensure the content of the program is maximally useful at the point of care.
Principal Systems Developer - DevSecOps InterSystemsPrincipal Systems Developer - DevSecOpsBoston, MassachusettsThis technical leadership role in the Database Platforms (DP) department will contribute to InterSystems’ next generation cloud-native database platform product as well as the InterSystems IRIS, InterSystems IRIS for Health and InterSystems Health Connect database platforms. The Platform Operations team needs an experienced developer or architect who can drive DevSecOps enhancements and maintenance including configuration, security, monitoring, licensing and upgrading for cloud with Kubernetes and traditional on-prem deployments on a range of supported platforms.
Principal Systems Developer - Devsecops InterSystemsPrincipal Systems Developer - DevsecopsBoston, MA$144,000–$205,000 / yearThis technical leadership role in the Database Platforms (DP) department will contribute to InterSystems' next generation cloud-native database platform product as well as the InterSystems IRIS, InterSystems IRIS for Health and InterSystems Health Connect database platforms. The Platform Operations team needs an experienced developer or architect who can drive DevSecOps enhancements and maintenance including configuration, security, monitoring, licensing and upgrading for cloud with Kubernetes and traditional on-prem deployments on a range of supported platforms.
Senior Principal AI Engineer Vertex PharmaceuticalsSenior Principal AI EngineerBoston, MassachusettsIn addition to building out the core platform, this engineer will own the vision and day-to-day operations of a centralized AI Gateway / Control Plane / Control Tower that enables agent monitoring, observability, policy enforcement, governance, and operational controls across AI solutions at Vertex. Demonstrated experience using AI-assisted software development and autonomous coding agents to design, generate, test, review, debug, optimize, and refactor code across complex enterprise systems.
Principal Network Engineer Sun Life FinancialPrincipal Network EngineerWellesley Hills, MA$70,300–$105,500 / yearAdvanced proficiency in Infrastructure as Code (IaC) using Terraform or AWS CloudFormation, paired with experience utilizing Generative AI developer tools (e.g., Amazon Q, Amazon Bedrock, or AI coding assistants) to accelerate code generation, automate network compliance validation, and scale CI/CD network deployment pipelines. The ideal candidate will have strong experience designing, implementing, and supporting enterprise network infrastructure, with expertise in Cisco routing and switching technologies, WatchGuard firewalls, AWS networking services, Infrastructure as Code, and utilizing Generative Developer tools.
Principal Mechanical Design Engineer RISE RoboticsPrincipal Mechanical Design EngineerSomerville, MAFounded in 2011 by graduates of MIT and RISD (Rhode Island School of Design), and backed by Engine Ventures, Techstars, Fortistar and Gates Corporation, RISE Robotics is leading the way to Zero Emission heavy machinery by providing the world’s most efficient and productive alternative to hydraulics. Proven technical aptitude and experience with electro-mechanical design and related manufacturing processes that might include: complex mechanical assemblies; rotating machinery; tolerance studies; design for assembly / manufacturing; EE and ME component and material selection; FMEA; design for life.