Atmospheric Scientist Jobs in the United States
Takeda
Boston, MA
Strong scientific background and experience with global Regulated assay development and validation across technology platforms in sample preparation methods as well as mass spectrometry platformsExperience with outsourcing and working with external partners to develop/transfer assays, oversee data generation/analysis and delivery of high-quality data from global clinical trials under regulated settings (GLP, GCP, GCLP and CAP/CLIA etc.).Experience within GI, immunology, neurology and/or oncology therapeutic areas, and experience supporting novel modalities. with 5+ years experience, MS with 10+ years experience, or BS with 12+ years experience; 5 years of Industry experience requiriedSignificant drug development experience from a bioanalytical chemistry perspectiveIn depth, expert knowledge of bioanalytical chemistry, including sample preparation procedures, HPLC and mass spectrometry (MS/MS) analysis techniques and instrumentation, and validation experimental design and related laboratory statistics.
Takeda
Boston, MA
POSITION OBJECTIVES:The Bioanalytical and Biomarker Sciences and Technologies (BST) department at Takeda is seeking a strong scientific leader to join the group as a biomarker development or bioanalytical expert with experience in one or more technologies including immunoassay, cell-based assays, flow cytometry, LCMS, and/or genomics, to support the clinical development of novel therapeutics across a range of disease areas including oncology, immunology, gastrointestinal, neuroscience. Success in this role will be evaluated by the ability to build effective partnerships with relevant colleagues within BST and across Takeda, and align and deliver on BST deliverables with a focus on high-quality and timely delivery of biomarker and bioanalytical data for ongoing clinical trials.
Takeda
Boston, MA
Experience with high performance computing, relational databases (e.g., SQL), and cloud computing or distributed computing (Amazon Web Services).InnovationReceives high level instructions on all work, determines methods for new assignments, works closely with manager, may manage junior staff Determines methods for new assignments; perform literature search as needed to propose and develops innovative solutionsInteractionConducts scientific presentations to internal audiencesDecision-making and AutonomyIndependently manages own workload Scientifically independent Ability to search literature and come up with innovative solution to difficult problemsLeadershipAbility to work in a team and influence team to make data driven decisionsEducation & Competencies PhD degree in Systems Biology, Bioinformatics or Computational Biology with 2+ years relevant experience, or MS with 8+ years relevant experience, or BS with 10+ years relevant experience. Accountabilities: Serve as a subject matter expert in projects requiring multi-omic and multi-modal analyses from preclinical and clinical studies to identify and execute biomarker studies, patient stratification, and identify novel drug targets/biomarkers.
Takeda
Boston, MA
Leads BST sub team of subject matter and logistical experts to coordinate execution of BST deliverables to support clinical trials in accordance with clinical study timelinesResponsible for overseeing implementation of biomarker and bioanalytical plans by working with BST sub team on vendor selection and oversight, contract executions, timely assay development and validation activities, and high-quality biomarker and bioanalytical data delivery to clinical trialsRepresents BST at cross functional teams (GPT, CST, SET) and keeps BST leadership informed of progressCollaborates cross functionally with Clinical Sciences, QCP, Regulatory, DMPK, Research and other functions to support program objectivesInfluences and inspires scientists in the organization, works effectively in the matrix environment, and maintains a culture that encourages innovation, scientific rigor, and growth opportunities. Lead will support the clinical development of novel therapeutics by developing translational and clinical biomarker strategies for preclinical and clinical programs through cross functional collaboration with NS Clinical Sciences, NS DDU, Clinical Pharmacology, DMPK and others as well as external experts in the field of NeuroscienceBST Lead will also oversee implementation of biomarker and bioanalytical strategies in clinical trials by working closely with BST biomarker and bioanalytical SMEs, study logistics and BST functional heads, and will monitor execution and ensure timely fit-for-purpose assay development and validation at CROs and data delivery to support decision making in clinical studies and portfolio progressionBST Lead will lead Translational and BST sub teams and will collaborate cross-functionally to align on strategy and plans, and assure effective delivery of data to clinical trials to support decision making.
Takeda
Boston, MA
This is a highly visible, strategic, and matrixed role, responsible for leading the Translational subteam (TST) partnering with Gastrointestinal and Inflammation Drug Discovery Unit (GI² DDU) research scientists and Gastrointestinal and Inflammation Therapeutic Area Unit (GI² TAU) physician-scientists and relevant partner lines and functions to identify and validate biomarkers relevant to patients in clinical studies. Lead Translational subteam (TST) and matrix leadership and collaboration across multiple functional areas, working closely with physician-scientists, clinical leads, clinical pharmacologists, BST, discovery research scientists, and non-clinical and other functions to build consensus for a fit-for-purpose biomarker strategy.
Takeda
Boston, MA
Works closely with colleagues from Takeda’s Neuroscience Drug Discovery Unit, Biomarker Sciences & Technologies, Clinical Imaging, Digital Health Sciences, Statistics, Computational Biology and Quantitative Clinical Pharmacology groups to ensure close alignment between scientific and clinical strategy. Serve as a key point of contact for translational activities in rare neurology disordersRepresents Takeda in interactions with the external scientific community and consortia effortsContributes to Takeda’s strategy in rare neurology disorders as a key member of the Rare Neurology Disorders Unit.
Takeda
Boston, MA
Join Takeda as an Associate Director of Protein Production where you will be an inspirational, strategic leader to oversee the strategic and technical operations for the production with close communication and collaboration with the analytical team to ensure robust production of high quality therapeutic proteins in Global Biologics. You will also have a deep expertise in high-quality antigen generation, protein production for structural studies, and high-throughput to medium, large-scale biologics production with deep expertise of analytical and biophysical characterization of therapeutic proteins.
Takeda
Boston, MA
Generate and execute preclinical development strategies to support candidate selection and mechanistic characterization, facilitating efficient clinical validation of impactful medicines for patients with inflammatory and autoimmune disordersApply deep scientific expertise in immunology and/or cell biology to creatively mature innovative novel concepts within our team, in matrixed collaboration with other Takeda scientists, and external partners. About the Role:The Gastrointestinal and Inflammation (GI2) Drug Discovery Unit at Takeda is building a new team of experienced, innovative, and collaborative researchers to deliver an industry-leading portfolio of drugs for various gastrointestinal, autoimmune, and inflammatory diseases.
Takeda
Boston, MA
Global Biologics (GB) mission is the discovery of transformative, innovative Biologics therapeutics to support Takeda's pipeline and advance novel therapeutics into clinical development in Takeda's three therapeutic areas of interest: Oncology (immuno-oncology, cell therapies), Gastroenterology, and Neuroscience, The In Vitro Pharmacology group plays a crucial role in evaluating the biological activity of potential therapies, selecting candidates for preclinical and clinical development. How you will contribute:Functional leadership: Lead and innovate in the design, development, and execution of in vitro pharmacology assays to assess the biological activity, mechanism of action, and efficacy of novel biologic therapies targeting GI diseases, inflammation, and neurological disorders.
Takeda
Cambridge, MA
Mentors, motivates, empowers, develops and retains staff to support assigned activities. EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS: Education and experienceMD or internationally recognized equivalent plus 3 years of clinical research experience within the pharmaceutical industry or biomedical/clinical experience within academia (or a combination of afore mentioned).Previous experience successfully leading matrix teams preferred.SkillsSuperior communication, strategic, interpersonal and negotiating skills.Ability to proactively predict issues and solve problems.Ability to drive decision-making within a multi-disciplinary, multi-regional, matrix teams.Diplomacy and positive influencing abilities.KnowledgeClinical and basic scientific knowledge of neurodegenerative disorders, especially dementia and Parkinson disease strongly preferred.Regional/global Provides leadership in meetings and negotiations with key opinion leaders, establishment of strategy for assigned compounds, and the direction of clinical scientists involved in developing documents required to outline the Company positions on research programs or regulatory applications (e.g.
Chenega Corporation
Ft Detrick, MD
The Genomics Computational Systems Biologist shall provide laboratory and scientific support within the Center for Genome Sciences (CGS) to perform next generation sequencing computational and analytical tools, comprising the ability to construct high-throughput analysis pipelines for omics data, and to integrate with in-house databases. Analyze large-scale and high-throughput genomics datasets generated from Pacific Biosciences, Oxford Nanopore and Illumina sequencers (e.g., whole genome sequencing and RNA-Seq).
Chenega Corporation
Ft Detrick, MD
Contractor shall support approximately 10 small animal studies in BSL-2, -3, and -4 laboratories, by autonomously running downstream analysis including assessment of viral replication (plaque assay and RT-qPCR), transcriptomic analysis (spatial, single cell and/or bulk), blood chemistry, viral antigen and/or antiviral antibody detection using in-house Luminex assays or ELISAs, determine cytokine and chemokines levels. Design and perform basic and specialized molecular biology techniques including but not limited to: PCR, qRT-PCR, DNA preparations and purification, cloning, transformations, fluorescence in-situ Hybridization (FISH), flow cytometry, Western blot, IFAs, high content imaging, plaque assays, PRNTs, and other molecular biology techniques and other assays to support ongoing projects.
Chenega Corporation
Ft Detrick, MD
Design novel protocols and technologies to build DSD capabilities that are based on pathogen and/or host biomarker characterization, immune response characterization to understand host immune response post infection or MCM application, small molecule toxin research to include understanding host biomarker responses post exposure, toxicity, and organoid models, as well as other diagnostics relevant technologies. Evaluate large datasets from biomarker characterization efforts to include building bioinformatic pipelines for data processing and analysis using open-source programming languages (R, Python, etc) as well as visualization of large datasets for reports and presentations.
Chenega Corporation
Ft Detrick, MD
Perform basic cell culture and basic virology assays such as plaque assays (PA), plaque reduction neutralization test (PRNT), PCR, qRT-PCR, DNA preparations and purification, cloning, transformations, fluorescence in-situ Hybridization (FISH), flow cytometry, Western blot, IFAs, high content imaging, plaque assays, PRNTs, virus propagation and purification and other assays to support ongoing projects. The Laboratory Technician 3 - Research Technical Support shall provide support in using animal models and in vitro models to evaluate vaccines performing immunogenicity studies such as cellular/humoral immune responses using ELISA, flow cytometry and other immunological techniques, as well as basic virology studies.
Chenega Corporation
Ft Detrick, MD
The Laboratory Technician shall provide laboratory support with laboratory experiments in BSL-2 and BSL-3 laboratories and thus must hold and maintain BPRP status, IAW the provisions in this contract and applicable regulations. The contractor shall aid in the execution of scientific studies and plaque assays, PCR and other assays, animal procedures, collection/data analyzing, and maintain laboratory and laboratory equipment.
Chenega Corporation
Ft Detrick, MD
Chenega Professional & Technical Services, LLC, a Chenega Professional Services’ company, is looking for a Scientist 1 - Therapeutics Research Scientific Support to support the United States Army Medical Research Institute of Infection Diseases by conducting basic and applied research on current and emerging threats in support of the biodefense and infectious disease program. Construct mutant bacterial and viral strains and perform phenotypic characterization of the mutants using in vitro (growth kinetics, intracellular growth within macrophages) and in vivo (determine LD50 studies, bacterial/viral infection studies etc) methods.
Talent Software Services, Inc.
West Point, PA
Appointees will work within multidisciplinary teams focused on the discovery of Client drug targets and development of biomarkers for clinical translation supporting new therapeutics. Preferred:Hands-on experience performing unbiased, quantitative discovery analyses with high resolution LC-MS instrumentation (i.e. DDA, DIA approaches using label-free or TMT quantification).
Talent Software Services, Inc.
San Diego, CA
Expertise in downstream analysis for common NGS data types, such as WGS/WES/panel-seq, bulk RNA-seq, single-cell RNAseq and spatial transcriptomics (experience in building NGS pipelines is not required but is a plus). We welcome applications from individuals with a track record of innovative translational research in immunology, regardless of their current setting (clinical, academic, or industrial).