GSK plcPrincipal Scientist, Protein Biochemistry GSK plcPrincipal Scientist, Protein BiochemistryCambridge, MA$115,500–$192,500 / yearYou will be expected to operate with a high degree of scientific independence, proactively identify and address technical risks, and introduce innovative approaches that elevate the performance, scalability, and impact of protein biochemistry workflows across the organization, including identifying opportunities to increase throughput and reproducibility and driving fit-for-purpose solutions from prototype to routine use. Advanced working knowledge of biophysical and analytical techniques used to characterize proteins at scale (e.g., mass photometry, mass spectrometry, differential scanning fluorimetry, HPLC/SEC, DSC, ITC, BLI, SPR), with a track record of using these data to guide construct strategy, workflow optimization, and program decisions.
Wave Life SciencesNewOligo Chemistry and Biochemistry Co-op (Fall 2026) Wave Life SciencesOligo Chemistry and Biochemistry Co-op (Fall 2026)Cambridge, MAOur toolkit of RNA-targeting modalities includes editing, splicing, RNA interference and antisense silencing, providing us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. Our diversified pipeline includes clinical programs in Duchenne muscular dystrophy, Alpha-1 antitrypsin deficiency and Huntington's disease, as well as a clinical program in obesity and a preclinical program in NASH/MASH.
Keros TherapeuticsResearch Associate Co-Op, Protein Biochemistry/Engineering Keros TherapeuticsResearch Associate Co-Op, Protein Biochemistry/EngineeringLexington, MA$28–$32 / hourWith a focus on developing differentiated product candidates that are designed to alter TGF- signaling, we aim to target the pathways critical for the growth, repair and maintenance of blood cells and a number of tissues, including bone, skeletal muscle, adipose and heart tissue. Support protein production efforts, including expression in mammalian systems, purification to achieve high quality reagents using FPLC, affinity, ion-exchange, and SEC chromatography, and continuous optimization of production methods for novel biomolecules.
Keros TherapeuticsResearch Associate Co-Op, Protein Biochemistry Keros TherapeuticsResearch Associate Co-Op, Protein BiochemistryLexington, MA$28–$32 / hourProtein expression: assist with routine mammalian expression of our therapeutic molecules to support ongoing studies, assess novel drug candidates through transient expression with CHO and HEK cells, establish stable cell-lines of new drug candidates when necessary. With a focus on developing differentiated product candidates that are designed to alter TGF- signaling, we aim to target the pathways critical for the growth, repair and maintenance of blood cells and a number of tissues, including bone, skeletal muscle, adipose and heart tissue.
Wave Life Sciences LtdOligo Chemistry and Biochemistry Co-op (Fall 2026) Wave Life Sciences LtdOligo Chemistry and Biochemistry Co-op (Fall 2026)Cambridge, MAOur toolkit of RNA-targeting modalities includes editing, splicing, RNA interference and antisense silencing, providing us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. Our diversified pipeline includes clinical programs in Duchenne muscular dystrophy, Alpha-1 antitrypsin deficiency and Huntington's disease, as well as a clinical program in obesity and a preclinical program in NASH/MASH.
Pride GlobalSenior Associate Scientist (Physical Biochemistry) Pride GlobalSenior Associate Scientist (Physical Biochemistry)Cambridge, MA$34.61–$41.54 / hourOnly applicable for San Francisco Candidates: Under the San Francisco Lactation in the Workplace Ordinance, we will provide written notice of lactation accommodation rights, and this notice will automatically be given upon hiring, any inquiry of parental leave or lactation accommodation. The Science Team at Russell Tobin and Associates is hiring a "Senior Associate Scientist - (Physical Biochemistry)" for a top leading pharmaceutical organization.
Boston UniversityLABORATORY TECHNICIAN, BS-Biochemistry - Lau Lab Boston UniversityLABORATORY TECHNICIAN, BS-Biochemistry - Lau LabBoston, MA$41,643–$42,000The candidate will work on NIH grant support investigations into how transposons mobilize and become expressed in model organism cells, like Drosophila, mouse and mosquito cells. Our group studies basic gene regulation mechanisms by small RNAs and the RNA interference pathway in model organisms.
Integrated Resources, IncScientist I Integrated Resources, IncScientist IWaltham, MA$50–$53 / hourContractorKey Responsibilities Perform characterization testing of gene therapy samples to determine and quantify host cell proteins using solid-phase enhanced sample preparation and LC-MS analytical techniques commonly used in proteomics (i.e. proteomic profiling using DDA or DIA, targeted quantitation using MRM or PRM). Basic Qualifications Masters degree in Analytical Chemistry, Biochemistry, or a related discipline with 2-4 years of relevant biotechnology or pharmaceutical industry experience, preferably performing impurity monitoring using LC-MS or proteome/HCP profiling or Doctorate degree with 1-3 years of relevant experience in proteomics.
Pyramid, IncScientist I Pyramid, IncScientist IWaltham, MA$40–$49 / hourContractorKey Requirements and Technology Experience: Skills-MASS SPECTROMETR, automation liquid handler, Method development and troubleshooting Master’s degree in Analytical Chemistry, Biochemistry, or a related discipline with 2-4 years of relevant biotechnology or pharmaceutical industry experience, preferably performing impurity monitoring using LC-MS or proteome/HCP profiling or Doctorate degree with 1-3 years of relevant experience in proteomics. Key Responsibilities: Perform characterization testing of gene therapy samples to determine and quantify host cell proteins using solid-phase enhanced sample preparation and LC-MS analytical techniques commonly used in proteomics (i.e. proteomic profiling using DDA or DIA, targeted quantitation using MRM or PRM).
Manifold BioScientist, cDNA Display Manifold BioScientist, cDNA DisplayBoston, MAResponsibilities: • Design, develop, and validate a cell-free display platform (cDNA display or similar) compatible with diverse binder formats • Work with automation team to scale and automate the platform to enable routine, high-throughput screening against large panels of therapeutic targets • Collaborate with ML and computational teams to ensure screening outputs feed effectively into model training pipelines • Work with the protein engineering team to support discovery campaigns and affinity maturation as platform capacity allows • Stay current on advances in cell-free display, laboratory automation, and computational protein design. Why you might be a good fit: Building systems that generate data at a scale previously impossible excites you You thrive in fast-moving environments where you own a problem end-to-end You are energized by working at the intersection of wet lab science, automation, and AI-driven biotherapeutic discovery You are a collaborative scientist who communicates well across teams with different technical backgrounds.
Exponent Inc.Scientist (Ph. D.) Exponent Inc.Scientist (Ph. D.)Natick, Massachusetts$125,000–$155,000 / yearYou will be responsible for: Analyzing scientific information to address microbiological, biological, and material science matters related to microbiological contamination root cause analysis, forensics, and product development, but also including a wide range of topics from medical devices and pharmaceuticals to consumer products and electronics. A strong theoretical and practical knowledge of various microbiological and biological assays (such as nucleic acid amplification tests, immunoassays, bacterial culture, protein quantification, and enzyme assays) and how material interactions can impact those techniques.
Vivo HealthStaffBioinformatics Scientist Vivo HealthStaffBioinformatics ScientistBoston, MA$170,000–$190,000 / yearEvery team member plays a crucial role in driving the future of biotech research, building the world's most efficient sequencing engine that operates overnight and scales globally. This role is heavily bioinformatics-focused, emphasizing deep domain expertise and the building of scalable products over general software platform skills.
PharmaEssentia U.S.A.Principal/ Senior Scientist – T Cell Engager & Multispecific Protein Engineering PharmaEssentia U.S.A.Principal/ Senior Scientist – T Cell Engager & Multispecific Protein EngineeringBEDFORD, MAFull timeRequired QualificationsPhD in Immunology, Protein Engineering, Biochemistry, Molecular Biology, or a related field, with 7+ years of relevant industry experience in biologics or protein therapeutics discovery (4+ years for Senior Scientist level). The successful candidate will combine deep expertise in protein engineering, antibody and multispecific formats, and immuno-oncology biology with strong scientific leadership and hands-on execution.
CEDENTSenior Scientist, Bioanalytical Sciences CEDENTSenior Scientist, Bioanalytical SciencesCambridge, MADevelop and oversee ligand-binding immunoassays (ELISA, MSD, Luminex or similar platforms) for the detection of translated proteins and anti-drug or anti-protein antibodies, including screening, confirmatory, and neutralizing antibody assays in accordance with regulatory guidance. You will be a subject matter expert in nucleic acid and protein bioanalysis, working to generate critical data that informs decision-making across preclinical and clinical development.
Harvard UniversityHMS - Research Associate (Cryo-EM Specialist) in Harvard Cryo-EM Center for Structural Biology, Department of Biological Chemistry and Molecular Pharmacology Harvard UniversityHMS - Research Associate (Cryo-EM Specialist) in Harvard Cryo-EM Center for Structural Biology, Department of Biological Chemistry and Molecular PharmacologyBoston, MA$80,000–$105,000 / yearThis facility houses sample preparation devices, including: • Vitrobot Mark IV • Wohlwend High Pressure Freezer • Leica EM AFS2 Freeze Substitution • Glacios 2 cryo-electron microscope with X-FEG fringe-free imaging • Selectris energy filter • Falcon4i direct electron detector. Responsibilities to Harvard Medical School will take place at the Harvard Cryo-EM Center for Structural Biology (HCCSB), a joint effort by Harvard Medical School, Dana-Farber Cancer Institute, Boston Childrens Hospital, Massachusetts General, Bringham, and Harvard FAS to provide state-of-the-art cryo-EM instrumentation and expertise for the structural biology community.
Keros TherapeuticsContract Senior Research Associate, Protein Science Keros TherapeuticsContract Senior Research Associate, Protein ScienceLexington, MA$65–$74 / hourWith a focus on developing differentiated product candidates that are designed to alter TGF- signaling, we aim to target the pathways critical for the growth, repair and maintenance of blood cells and a number of tissues, including bone, skeletal muscle, adipose and heart tissue. Our group exploits multidisciplinary approaches in protein sciences and protein engineering, to better the understanding of the biochemical, biophysical, and structural functional properties of the biomolecules within the TGF- superfamily that drive the signaling pathway.
Integrated Resources, IncSenior Process Engineer (Biologic Drug Substance / Technology Transfer Integrated Resources, IncSenior Process Engineer (Biologic Drug Substance / Technology TransferBoston, MAAs a technical subject matter expert, this role partners with Process Development and Clinical Supply (PDCS), the internal non-GMP pilot network, company Operations, Quality (QA), Regulatory (RA), and internal/external manufacturing sites to plan and execute transfer activities, ensure GMP-compliant manufacture, and drive process readiness. Serve as technical SME for routine activities for biologics tech transfer & GMP manufacture and validation including but not limited to creation/review of technical protocols or reports, manufacturing records, & quality records, sample plan coordination, and monitor & trend manufacturing batch performance.
Northeastern UniversityAssociate Research Scientist Northeastern UniversityAssociate Research ScientistBoston, MA$67,855–$95,845 / yearThe Antibiotic Discovery Center (ADC) at Northeastern University is an interdisciplinary research hub dedicated to discovering, characterizing, and developing novel antibiotics and bioactive natural products. Researchers at the ADC work collaboratively to identify new compounds from diverse microbial sources, elucidate their mechanisms of action, and advance them toward preclinical development through innovative screening, analytical, and genomic approaches.
RD PartnersQuality Control Microbiologist RD PartnersQuality Control MicrobiologistNorton, Massachusetts£74,880–£93,600Perform routine/non-routine analytical (HPLC/UPLC) and/or microbiological assays for raw materials, in-process samples, product release, and stability studies following SOPs. R&D Partners is a global functional service provider and strategic staffing resource specializing in scientific, clinical research & engineering.
LanceSoft IncMicrobiologist LanceSoft IncMicrobiologistNorton, MAFull timePerform routine and non-routine microbiological assays (bioburden, TOC, endotoxin, conductivity), with increasing complexity, to support critical utility samples, in-process samples, and product release, following established SOPs Maintain up-to-date training records, adhere to the testing schedule, and ensure the timely completion of all assignments to support the seamless operation of QC activities and uphold the department's commitment to meeting project timelines and quality metrics Assist in the maintenance of laboratory equipment and inventory to ensure smooth laboratory operations Ensure data is submitted timely; may qualify as a data reviewer to ensure timely and efficient data availability. Collaborate with QC and cross-functional teams to ensure seamless quality control operations and to support the collective company goals Participate in inspection readiness activities as well as supporting onsite audits and inspections, as needed.
Novartis AGPrincipal Scientist, ADPKD Biology Lead (Renal Research) Novartis AGPrincipal Scientist, ADPKD Biology Lead (Renal Research)Cambridge, MA$108,500–$201,500 / yearThe role will translate insights from human genetics and disease biology into differentiated target hypotheses, lead target triage and validation in advanced human-relevant model systems, including 3D platforms, and deliver decision-grade biology packages to enable robust, biology-driven portfolio go/no-go decisions and progression to preclinical proof-of-concept. Strong hands-on understanding of state-of-the-art in vitro methods, including molecular biology, biochemistry, and cellular analytics, as well as translatable cellular disease models in both 2D and 3D systems (advanced kidney organoids).
BrukerSenior Scientist BrukerSenior ScientistNewton, Massachusetts$99,450–$177,000 / yearFull timeThe ideal candidate should have demonstrated wet lab experience working independently in a biophysics, chemistry, biochemistry, or molecular biology laboratory, have exceptional attention to detail, be creative, and be able to critically analyze data and communicate results to the team. Responsibilities: • Support and spearhead the method development and optimization of novel molecular biology assay schemes for spatial omic applications including molecular barcoding, fluorophore marking, nucleic acid hybridization, amplification and sequencing techniques, and probe library preparation.
Generate Biomedicines IncNewSenior Director, Protein Analytics & Biophysics Generate Biomedicines IncSenior Director, Protein Analytics & BiophysicsSomerville, MA$210,000–$290,000 / yearSuccess in this role will require enterprise leadership: developing leaders and senior scientists, building an inclusive and high-accountability culture, partnering deeply across Protein Sciences, Prototyping, Technology, Data Sciences, Machine Learning, Biology, and CMC/Tech Ops, and translating an ambitious scientific vision into robust capabilities that improve decision quality, speed, and scale. The ideal candidate brings deep technical breadth, a quantitative mindset, and a clear point of view on how pooled assays, DNA/barcode-enabled readouts, synthetic biology, automation, microfluidics, advanced detection, and computational modeling can transform how protein therapeutics are evaluated.
Alnylam PharmaceuticalsNewSenior Scientist, Cell Biology Alnylam PharmaceuticalsSenior Scientist, Cell BiologyCambridge, MA$126,400–$189,600 / yearLearn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careersAboutAlnylamWe are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).Alnylam's robust Total Rewards package is designed to support your overall health and well-being.
Pfizer IncNewAssociate Scientist Pfizer IncAssociate ScientistAndover, MA$60,200–$100,400 / yearThe ideal candidate will have knowledge in protein biochemistry and analytical chemistry, and experience using some or all of the following techniques: all modes of HPLC/ UPLC, SDS-PAGE, iCE, CE, and/or peptide mapping for analysis of biologicals including proteins, antibodies, peptides, and conjugates. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act.
Artech LLCScientific - Research Scientist Research Scientist Artech LLCScientific - Research Scientist Research ScientistCambridge, MA$45–$50.90 / hourThis role is heavily focused on wet lab work and will contribute to cutting-edge research projects aimed at understanding cancer biology, identifying Client drug targets, and developing new therapeutic approaches. QualificationsBachelor’s or Master’s degree in Biological Sciences, Molecular Biology, Biochemistry, or a related field with extensive and demonstrated experience conducting oncology research in an academic or industry setting.
Compass TherapeuticsPrincipal Analytical Scientist, CMC Compass TherapeuticsPrincipal Analytical Scientist, CMCBoston, MA$140,000–$188,000 / yearDemonstrated expertise applying analytical techniques for protein analysis, including binding ELISAs, chromatographic purity assays, cell-based potency assays, extended characterization, routine compendial assays, and analytical comparability in support of commercialization. We have a robust pipeline of novel product candidates designed to target multiple key biological pathways to drive an effective anti-tumor response, including angiogenesis modulation, immune activation within the tumor microenvironment, and reduction of tumor-driven immunosuppression.
Boston Medical CenterNewInpatient Clinical Dietitian (Registered Dietitian Boston Medical CenterInpatient Clinical Dietitian (Registered DietitianBoston, MA$33.36–$42.52 / hourProvides nutritional care when consulted for several malnourished and/or critically ill patients; diagnoses malnutrition and documents in EHR using BMC approved malnutrition diagnostic criteria; utilizes the nutrition-focused physical exam to assess nutritional status; evaluates patient's nutritional needs and develops nutritional care plan; determines solutions for total parenteral nutrition and tube feedings when appropriate and submit to MD for approval as well as chart in the medical records. Additional advanced board certifications preferred for complex patient population: Certified Nutrition Support Clinician (CNSC), Certified Lactation Counselor (CLC), Pediatric Critical Care Nutrition (CSPCC), Certified Pediatric Nutrition (CSP), Certified Specialist in Obesity and Weight Management (CSOWM), Certified Diabetes Educator (CDE), or other advanced board certification.
Alloy TherapeuticsScientist / Senior Scientist, Bioanalytical LC–MS – Oligonucleotide Alloy TherapeuticsScientist / Senior Scientist, Bioanalytical LC–MS – OligonucleotideWaltham, MAFull timeThis LC–MS-focused role involves generating and interpreting data on oligonucleotide exposure, stability, metabolism, protein binding, and structural integrity to answer DMPK-relevant questions and link analytical findings with PK/PD and biological activity. Exposure & Disposition: Apply LC–MS and other methods to assess oligonucleotide–protein interactions, binding, and disposition, interpreting how stability, metabolism, and chemical modifications influence systemic and tissue exposure.
Boston UniversityPostdoctoral Associate, Amyloidosis Center, Boston University Chobanian Avedisian School of Medicine Boston UniversityPostdoctoral Associate, Amyloidosis Center, Boston University Chobanian Avedisian School of MedicineBoston, MA$67,500–$70,000Demonstrated experience (ideally publications or preprints) in one or more of the following areas is highly desirable: Tissue culture, including flow cytometry, toxicity assays and generation of stable cell lines. Working with our unique archive of clinical data and samples, the successful candidate will apply a range of approaches including protein biochemistry and cell biology to model systems and patient samples.
Massachusetts Institute of TechnologyPostdoctoral Associate, Stark Lab Massachusetts Institute of TechnologyPostdoctoral Associate, Stark Labcambridge, MAD. in immunology, glycobiology, synthetic biology, or a related area; experience managing an independent research project to completion and publication; a track record of innovation; excellent problem-solving, interpersonal, and oral and written communication skills; and ability to learn quickly, function both independently and as part of a team, and work with a variety of people from all backgrounds and at all levels of training. Experimental approaches used in the lab include cloning/molecular biology, protein engineering and biochemistry, mammalian cell/tissue culture, flow cytometry, next-generation sequencing, transcriptomics, and animal models of disease.
Broad InstituteNewPostdoctoral Associate - The Gupta Lab Broad InstitutePostdoctoral Associate - The Gupta LabCambridge, MACollaborative Co-Mentorship: To broaden your expertise and support network, you will be co-advised by Dr. Aaron Hakim, a physician scientist, transplant hepatologist and Instructor in Medicine at Harvard Medical School, offering a dynamic environment that bridges distinct scientific perspectives. The fellow will utilize genome-wide CRISPR screens, including in combination with single cell RNA sequencing, to identify novel genetic mediators of disease-relevant cellular phenotypes for chronic liver disease.
Flagship Pioneering IncNewSenior Scientist, Molecular Biology Flagship Pioneering IncSenior Scientist, Molecular BiologyCambridge, MA$126,000–$181,500 / yearWe are looking for a Senior Scientist, Molecular Biology with experience in protein engineering, complex DNA library design, and pooled screening to help build next-generation DNA constructs for programmable medicines. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture.