UNKNOWN

FEED

Studies will focus on the PFKFB2-regulated fructose-2,6-bisphosphate axis and its downstream effects on mitochondrial biology, redox signaling, and Ca²? handling in the heart, with particular emphasis on how disruption of this pathway contributes to arrhythmogenic phenotypes and cardiac dysfunction. Located in Oklahoma City, a city that offers a dynamic and flourishing downtown area, with low cost of living, short commute times and a diversified economy, OMRF has been voted one of the Top Workplaces since the inception of the award.

Position Overview and Responsibilities 
A temporary Postdoctoral Scientist position is available in the laboratory of <a href="https://omrf.org/scientist/kenneth-m-humphries-ph-d/" rel="nofollow">Dr. Kenneth Humphries</a> within the <a href="https://omrf.org/science/research-programs/#aging-metabolism" rel="nofollow">Aging & Metabolism Research Program</a> at OMRF to study the intersection of glycolytic regulation and electrophysiology. Studies will focus on the PFKFB2-regulated fructose-2,6-bisphosphate axis and its downstream effects on mitochondrial biology, redox signaling, and Ca²? handling in the heart, with particular emphasis on how disruption of this pathway contributes to arrhythmogenic phenotypes and cardiac dysfunction. This is a mentored position for postdoctoral training.Incumbents at this level are responsible for the following: 
• Planning, designing and conducting research experiments 
• Managing research projects 
• Preparing reports and papers for publication, presentation and future research 
• Contributing to grant writing 
• Encouraged to write applications for fellowshipsThere is potential for qualified applicants to be accepted onto an NIA-funded T32 training grant fellowship.Minimum Qualifications<ul><li>Ph.D. in a biological science, chemistry, physics or other relevant area, M.D., or equivalent.</li><li>Highly motivated and enthusiastic about science.</li><li>Must be detail oriented, organized, and able to work independently, as well as part of a team.</li><li>Excellent oral and written communication skills.</li><li>Ability to communicate and write summaries of results.</li></ul>Preferred Qualifications<ul><li>Previous research experience in cardiac physiology and biochemistry is highly preferred.</li><li>Competitive individuals will have experience and knowledge of cardiac physiology, function, histology and biochemistry as well as basic molecular and biochemical techniques.</li><li>Competitive candidates will also demonstrate proficiency in interpreting assay results, summarizing findings, and assisting with manuscript preparation, grant writing, supervising graduate students and presenting data at national meetings.</li></ul>OMRF Overview 
Founded in 1946, the <a href="https://omrf.org/" rel="nofollow">Oklahoma Medical Research Foundation (OMRF)</a> is among the nation’s oldest, most respected independent, nonprofit biomedical research institutes. OMRF is dedicated to understanding and developing more effective treatments for human diseases, focusing on critical research areas such as Alzheimer’s disease, cancer, lupus, multiple sclerosis, and cardiovascular disease. OMRF follows an innovative cross-disciplinary approach to medical research and ranks among the nation’s leaders in patents per scientist. 
Located in Oklahoma City, a city that offers a dynamic and flourishing downtown area, with low cost of living, short commute times and a diversified economy, OMRF has been voted one of the Top Workplaces since the inception of the award. This achievement has been accomplished thanks to OMRF individuals who share a unified understanding that our excellence can only be fully realized with a collective commitment to our mission, “. . . so that more may live longer, healthier lives.” Successful candidates will demonstrate commitment to this mission. 
OMRF is an Equal Opportunity Employer.

Oklahoma Medical Research Foundation

Temporary Postdoctoral Scientist - Humphries Lab

Alzheimer's

Assays

Biochemistry

Biology

Biomedical Research

Cancer

Cardiology

Cardiovascular Disease

Chemistry

Communication Skills

Detail Oriented

Disease

Disease Treatment

Grant Administration/Management

Grant Writing

Histology

Human Diseases

Medical Research

Multiple Sclerosis

Nonprofit

Organizational Skills

Patents

Physics

Physiology

Presentation/Verbal Skills

Project/Program Management

Publications

Regulations

Reporting Skills

Research Skills

Writing Skills

clearcompany

Position Summary: As a Process Development Scientist, you will support the development, optimization, and scale-up of mammalian upstream bioprocesses for the manufacture of biologic drug substances. Experience: · 4-8 years of hands-on experience in a bioprocessing or biopharmaceutical development environment (academic or industrial); some education qualifications may substitute for some years of experience.

Position Summary:As a Process Development Scientist, you will support the development, optimization, and scale-up of mammalian upstream bioprocesses for the manufacture of biologic drug substances. You will contribute to the design and execution of laboratory experiments, data analysis, and technical documentation.Key Responsibilities:· Perform laboratory experiments to support mammalian upstream (cell culture) process development.· Assist in the optimization of bioprocess parameters for yield, purity, and product quality.· Support scale-up and technology transfer of processes to manufacturing or pilot facilities.· Prepare buffers, media, and other solutions according to SOPs and protocols.· Operate and maintain flask and bioreactor equipment.· Collect, analyze, and interpret experimental data; maintain accurate lab records and electronic notebooks.· Present findings in internal and client meetings and contribute to technical reports and regulatory documentation.· Complete Root Cause Analyses as needed.· Follow all safety, quality, and compliance requirements. Qualifications:Education:· Bachelor's, master's or PhD degree in Chemical Engineering, Biochemistry, Biotechnology, Biology, or related field.Experience:· 4-8 years of hands-on experience in a bioprocessing or biopharmaceutical development environment (academic or industrial); some education qualifications may substitute for some years of experience.· Experience in a CDMO environment is preferred.· Experience with suspension mammalian cell culture and stirred tank bioreactors is required.· Knowledge of protein purification and analytical techniques is a plus.Skills and Knowledge:· Understanding of cGMP, GLP, or other regulatory standards (preferred).· Strong analytical and problem-solving skills.· Good written and verbal communication skills.· Ability to work both independently and in a collaborative team environment.<img alt="" height="1" src="https://jbgr.la/t/v/H4sIAAAAAAAA_6tWyspP8kxRslIyNjezMFfSUUrKTyxKAYsYAXklmbmpxSWJuQVKVnmlOTm1eklJOUXuuvneySU-7h6VUXnmTpHOxRnGxklhRe6-lb6mFr4WoZaFqRGBiZ4AxPV64FwAAAA=" width="1"/>

Wheeler Bio, Inc.

Process Development Upstream Scientist

Academic Background

Analysis Skills

Biotech and Pharmaceutical

Cell Cultures

Chemical Engineering

Current Good Manufacturing Practice (cGMP)

Data Analysis

Documentation

GLP (Good Laboratory Practices)

Problem Solving Skills

Process Development

Process Manufacturing

Protein Purification

Record Keeping

Regulatory Reports

Standard Operating Procedures (SOP)

Team Player

Technical Writing

Brightmove

The Senior Director of Process Development is a senior technical and people leader responsible for the strategic oversight, execution, and continuous improvement of upstream, downstream, and cell line development activities in support of client-sponsored programs and internal technology platforms. The position serves as a key interface between clients, manufacturing, quality, regulatory, and business development, playing a critical role in maintaining the Wheeler Bio’s technical excellence, operational readiness, and client satisfaction.

Position SummaryThe Senior Director of Process Development is a senior technical and people leader responsible for the strategic oversight, execution, and continuous improvement of upstream, downstream, and cell line development activities in support of client-sponsored programs and internal technology platforms. This role ensures robust, scalable, and compliant processes that enable successful technology transfer into GMP manufacturing and support regulatory filings across preclinical through commercial stages.The position serves as a key interface between clients, manufacturing, quality, regulatory, and business development, playing a critical role in maintaining the Wheeler Bio’s technical excellence, operational readiness, and client satisfaction. Key ResponsibilitiesStrategic & Technical Leadership:·         Define and execute process development strategy aligned with company growth objectives and client portfolio needs·         Oversee development of scalable, robust, and cost-effective processes for biologics and/or advanced therapeutics (e.g., monoclonal antibodies, multi-specific antibodies, recombinant proteins)·         Ensure scientific rigor and data integrity across all development activities·         Stay current with emerging technologies, regulatory guidance, and industry trends to maintain competitive advantageProgram & Client Management:·         Serve as senior technical lead and escalation point for client programs·         Provide expert guidance during client engagements, proposal development, and technical due diligence·         Ensure development timelines, budgets, and deliverables meet client and internal expectations·         Support technical sections of regulatory submissions (INDs, IMPDs, BLAs, MAAs)Operational Excellence & Technology Transfer:·         Drive seamless technology transfer from development to GMP manufacturing·         Partner closely with Manufacturing, Quality, Supply Chain, and MSAT to ensure process robustness and readiness·         Establish phase-appropriate and risk-based development approaches and control strategiesPeople & Organizational Leadership:·         Lead, mentor, and develop a multidisciplinary team of scientists and managers·         Build a high-performing, collaborative culture focused on accountability and continuous improvement·         Support workforce planning, hiring, and talent development initiatives·         Establish clear performance expectations and career development pathwaysCross-Functional Collaboration:·         Collaborate with Business Development on proposals, technical assessments, and client onboarding·         Partner with R&D, MSAT, Manufacturing, Quality, Regulatory Affairs, and Supply Chain to ensure integrated execution·         Provide executive-level technical input to leadership teams and governance bodies Required QualificationsEducation:Master’s degree or above in Chemical Engineering, Biochemistry, Biotechnology, Chemistry, or related disciplineExperience:·         12+ years of progressive experience in biopharmaceutical process development, with direct experience in a CDMO regulated manufacturing environment·         Proven leadership experience managing scientific teams and complex client programs, as well as experience in client-facing leadership roles·         Demonstrated success developing and scaling processes from early development through commercialization·         Experience supporting regulatory filings and health authority interactionsTechnical Expertise:·         Deep knowledge of mammalian upstream and/or downstream process development for biologics or advanced therapies·         Strong understanding of GMP manufacturing, process scale-up, and tech transfer·         Experience in establishing and maintaining platform processes·         Familiarity with analytical development, characterization, and control strategies·         Experience applying QbD, DoE, and risk management toolsKey Competencies:·         Strategic thinking and decision-making·         Strong leadership, communication, and influencing skills·         Client-centric mindset·         Scientific rigor and problem-solving ability·         Ability to operate effectively in a fast-paced, deadline-driven environment<img alt="" height="1" src="https://jbgr.la/t/v/H4sIAAAAAAAA_6tWyspP8kxRslIyNje2NFTSUUrKTyxKAYsYAXklmbmpxSWJuQVKVnmlOTm1eoXOmcFBoalByQY5hgZJBu5Zbmb-lcbOPk4BXuF5TiGWhSkheZW6OeGpRckA0IAIplwAAAA=" width="1"/>

Biochemistry Jobs in Oklahoma City, OK

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Biochemistry Jobs in Oklahoma City, OK

Temporary Postdoctoral Scientist - Humphries Lab Oklahoma Medical Research Foundation

Process Development Upstream Scientist Wheeler Bio, Inc.

Senior Director, Process Development Wheeler Bio, Inc.

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