Principal Scientist/Sr. Principal Scientist, Computational Chemistry & Molecular Design Antares TherapeuticsPrincipal Scientist/Sr. Principal Scientist, Computational Chemistry & Molecular DesignBoston, Massachusetts$185,000–$240,000 / yearAs a member of a highly integrated team of medicinal chemists, machine learning scientists, structural biologists, biologists, and chemical biologists, you will apply and advance the full range of modern computational methods — structure- and ligand-based design, molecular dynamics, free energy perturbation (FEP), and machine-learning / generative approaches — to assess and prioritize targets, identify high-quality starting points, and drive lead optimization toward development candidates. Serve as the computational chemistry function lead on programs, providing integrated leadership across target validation, hit identification, hit-to-lead, and lead optimization for multiple small-molecule programs.
Computational Synthetic Chemist Ginkgo BioWorks IncComputational Synthetic ChemistBoston, MA$115,000–$165,000 / yearIndependent route-design judgment under real constraints on materials, time, building blocks, and execution resources, supported by a broad synthetic-organic reaction toolkit and strong purification and characterization skills. Design, select, and execute practical multi-step routes to novel drug-like singleton compounds and focused sets under real constraints on time, materials, building blocks, and available resources.
Research Leader / Senior Scientist (Computational Drug Design), Cambridge, MA Isomorphic LabsResearch Leader / Senior Scientist (Computational Drug Design), Cambridge, MACambridge, MAClassification of protected categories is as follows: A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability. Proven track record of project leadership / leading computational chemistry efforts on drug discovery programs, demonstrating significant contributions to project progression (ideally from hit identification through to lead optimisation or candidate nomination).
Scientist Cell Signaling TechnologyScientistDANVERS, MA$134,117–$160,126 / yearThis includes nested & two-step PCR, melt curve analysis, experience with hairpins /self-dimers /cross-dimers in primer designs, mastery PCR troubleshooting, experience with PCR additives, experience with gradient PCR, melting temperature (Tm) balancing, multiplex PCR. All resumes submitted by search firms/employment agencies to any employee at Cell Signaling Technology (CST) via email, the Internet, or in any form and/or method will be deemed the sole property of CST unless CST engaged such search firms/employment agencies for this position and a valid agreement with CST is in place.
Senior/Principal Scientist, Synthetic Biology Fieldstone BioSenior/Principal Scientist, Synthetic BiologyWoburn, MassachusettsFieldstone Bio is looking for a highly motivated Senior Scientist or Principal Scientist to join our growing Synthetic Biology team, where they will work to design, build, and test microbial biosensors for function in lab-, soil-, water-, and rock-based environments. A successful candidate will independently contribute to sensor design, construction, and testing, leveraging synthetic biology expertise to identify the genetic parts and microbial chassis most suited for the program.
Head of Translational Sciences, Drug Design, Cambridge, MA Isomorphic Labs LimitedHead of Translational Sciences, Drug Design, Cambridge, MACambridge, MAThis team will be highly collaborative and need to establish strong scientific relationships with multiple groups in the company, from Medicinal Chemists to Applied Machine Learning Scientists, creating a powerful symbiotic relationship that drives our internal and collaborative portfolios. Direct all in vitro and in vivo biology operations in Cambridge, MA through a network of CROs to generate, ingest and interpret high quality experimental data efficiently to support all aspects of our drug design programs from HitID through to IND.
Director, Translational Medicine, Oncology, Cambridge, MA Isomorphic Labs LimitedDirector, Translational Medicine, Oncology, Cambridge, MACambridge, MABy harnessing AI's powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world's most devastating diseases. Collaborate with AI and Computational Biology teams to identify, create and utilize innovative tools for analysis of biomarker and translational datasets, accelerate diagnostic advances and explore new approach methodologies (NAMs).
Advisor - Agent Research Eli Lilly and CompanyAdvisor - Agent ResearchBoston, MA$151,500–$222,200 / yearOur current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women's Initiative for Leading at Lilly (WILL). Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve.
Associate Director, Translational Medicine, Neuroscience Bristol Myers SquibbAssociate Director, Translational Medicine, NeuroscienceCambridge Crossing, MA$184,060–$223,036 / yearLeads small and large collaborations with academia and industry partners to identify biobanks, clinical trials and existing databases to collate multi-parameter genomic, immune and clinical datasets to mine for novel biomarkers of unmet need patients in conjunction with computational biologists, data scientists and statisticians. Collaborate and guide bioinformatics partners on biological questions to deliver biomarkers and biological understanding from whole transcriptome, whole exome, and/or whole genome data, epigenetics, proteomics, immune profile and single cell data in order to support drug discovery and development in Alzheimer's /Neurological Diseases.
Senior Research Support Associate Massachusetts Institute of TechnologySenior Research Support AssociateCambridge, MAExamples could include: Laboratory experiments: microscopy, molecular biology (cloning, RNA extraction, etc), behavior experiments, and generating transgenic jellyfish by microinjection of oocytes, Computational biology: developing imaging processing pipelines to accompany new microscopes being built; solve other machine vision problems for behavior tracking; analysis and modelling of neural activity and/or behavior data, and Engineering: building novel microscopy and/or behavior recording setups. SENIOR RESEARCH SUPPORT ASSOCIATE, Biology - Weissbourd Lab, to support ongoing projects with contributions ranging from wet lab work to computational expertise, engineering, and other fields.
AI Scientist ProximaAI ScientistBoston, MAExpertise in ideally several of the following topics: diffusion models, flow matching, transfusion, discrete diffusion, latent diffusion, VAEs, image generation, video generation, LLMs, multimodal LLMs, pre-training, post-training, reinforcement learning, SFT, DPO/GRPO, conditioning, classifier(-free) guidance, LORA, constrained generation scaling, distributed training, tokenization, geometric deep learning, equivariant models, structure-based drug design (SBDD), structure prediction / cofolding, curriculum learning, multi-task learning, transfer learning. Neo-1 enables rapid exploration of chemical and structural space for high value, previously intractable targets, and in particular unlocks small molecule proximity therapeutics like molecular glues with AI for the first time.
Computational Theoretical Chemist III 1910Computational Theoretical Chemist IIIBoston, MassachusettsStrong understanding of key concepts, including potential energy surfaces (PES), intermolecular and intramolecular forces/interactions, force fields, molecular properties, thermodynamic properties, solvation models (implicit/explicit), and conformational sampling. We are the only AI-native biotech, pioneering small and large molecule therapeutics discovery by integrating massive multimodal data, frontier AI models, and high-throughput lab automation into an infrastructure for AI-enabled drug discovery.
Computational Theoretical Chemist II 1910Computational Theoretical Chemist IIBoston, MassachusettsStrong understanding of key concepts, including potential energy surfaces (PES), intermolecular and intramolecular forces/interactions, force fields, molecular properties, thermodynamic properties, solvation models (implicit/explicit), and conformational sampling. We are the only AI-native biotech, pioneering small and large molecule therapeutics discovery by integrating massive multimodal data, frontier AI models, and high-throughput lab automation into an infrastructure for AI-enabled drug discovery.
Computational Theoretical Chemist I 1910Computational Theoretical Chemist IBoston, MassachusettsStrong understanding of key concepts, including potential energy surfaces (PES), intermolecular and intramolecular forces/interactions, force fields, molecular properties, thermodynamic properties, solvation models (implicit/explicit), and conformational sampling. We are the only AI-native biotech, pioneering small and large molecule therapeutics discovery by integrating massive multimodal data, frontier AI models, and high-throughput lab automation into an infrastructure for AI-enabled drug discovery.
Neurodegenerative Disease Senior Scientist Convergent ResearchNeurodegenerative Disease Senior ScientistWatertown, MAFull timeDay-to-day responsibilities include designing and carrying out experiments to isolate and profile single cells from brain tissue, computationally analyzing large-scale single-cell proteomics datasets, preparing manuscripts and presentations, mentoring junior scientists, and regular meetings with collaborators in and outside of PTI. Parallel Squared Technology Institute (PTI) is a non-profit research institute developing technologies, reagents, and computational tools to increase the sensitivity and throughput of protein analysis, with a specific focus on single-cell proteomics.
Staff Scientist I/Flow Cytometry Lahey Hospital and Medical CenterStaff Scientist I/Flow CytometryBoston, MA$100,006–$140,005 / yearFor non-bench research, non-clinical staff scientists, knowledge of epidemiology, outcomes research, evidence-based medicine, and experience using longitudinal datasets, data repositories and statistical Analysis with SAS, STATA or SPSS. Problem Solving: Ability to address problems that are broad, complex and abstract, often involving Medical Center-wide issues and requiring substantial creativity, resourcefulness, staff engagement, Lean diagnostic techniques, negotiation and diplomacy to develop solutions.
NewResearch Scientist ICON PlcResearch ScientistCambridge, MA$68,616–$85,770 / yearPerform clinical sample testing, including nucleic acid isolation, nucleic acid quantification and QC, library preparation (manual/automation), data analysis, and reporting laboratory results as directed. As a Research Scientist at ICON, you will play a key role in clinical sample testing, assay development, and data analysis within a CLIA/CAP-accredited laboratory environment.
Senior Scientist II/Principal Scientist, Molecular Cloning Technologies Flagship Pioneering IncSenior Scientist II/Principal Scientist, Molecular Cloning TechnologiesCambridge, MA$143,000–$214,500 / yearFlagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Research Associate II, NGS AlltrnaResearch Associate II, NGSCambridge, MA$74,000–$94,500 / yearThe company's initial therapeutic programs are designed to restore full-length protein production in diseases caused by premature termination codons (PTCs), collectively referred to as Stop Codon Disease, which affect approximately 10% of people with a rare genetic disease. Alltrna's NGS pipeline is central to company initiatives, and this role will collaborate closely with a cross-functional team of scientists in molecular biology, computational biology, and lab automation.
Associate Director/Director, Data Science (Real World Data) Formation BioAssociate Director/Director, Data Science (Real World Data)Boston, MA$213,500–$267,000 / yearRecognizing that this development bottleneck may ultimately limit the number of new medicines that can reach patients, Formation Bio, founded in 2016 as TrialSpark Inc., has built technology platforms, processes, and capabilities to accelerate all aspects of drug development and clinical trials. Partner with Data Science, Clinical Development, Business Development, and Engineering teams to define RWD use cases (trial feasibility, synthetic control arms, epidemiology, label expansion) and productize ad hoc pipelines into scalable, production-grade systems.