div class="posting-requirements plain-list">PhD in Bioinformatics, Computational Biology, or related quantitative field (or MS with 5+ years relevant industry experience);
Demonstrated track record applying computational TF ranking and GRN inference to cellular reprogramming problems, transdifferentiation, directed differentiation, or iPSC systems;
Multi-platform single-cell RNA-seq expertise: hands-on analysis from at least two different platforms, including platform-specific troubleshooting and quality control;
Multi-modal genomics proficiency: ChIP-seq, CUT&RUN, or ATAC-seq analysis including peak calling, differential accessibility, and TF motif enrichment;
Hands-on experience with established GRN inference methods to nominate or rank regulators of cell state, beyond literature-curated lists;
Experience analyzing pooled perturbation screens (CRISPRa, CRISPR knockout, or barcoded TF overexpression) with single-cell or bulk readouts;
Working knowledge of trajectory inference and pseudotime methods for mapping cell state transitions;
Strong programming skills in Python and R, with proficiency in Scanpy/Seurat and statistical analysis for high-dimensional data;
Comfortable working in a modern computational environment: cloud platforms, workflow managers, containerization, and collaborative version control;
Strong publication record and demonstrated cross-functional collaboration with experimental biologists.
Lead end-to-end TF discovery for cellular reprogramming - from multi-platform single-cell genomics analysis (scRNA-seq, ATAC-seq) through GRN inference, differential analysis, and trajectory mapping - to nominate the regulators that flip cell fate.
You will diagnose and resolve issues across next-generation sequencing (NGS) workflows, translate complex concepts into practical guidance, and champion customer needs with cross-functional teams. Your Superpowers in Action: Serve as the dedicated technical support contact for Newborn Screening scientists and bioinformatics users via phone, email, and on-site visits, ensuring timely, high-quality resolutions.
Expertise including RStudio, Shiny framework, GitHub code version control, Seurat, DESeq2, and have experience with bulk and single-cell dataset analysis workflows including data normalization, dimensionality reduction, and clustering. Their research is built around teamwork and covers four key areas: Precision Systems Oncology, Cancer Data Science (including computer biology, bioinformatics, and biostatistics), Chemical Biology and Experimental Therapeutics, and Cancer Population Science.
Portland, Oregon30+ days ago
ul>- Conduct advanced research in gamete, embryo, stem cell, and molecular biology, including gamete and embryo micromanipulation; in vitro gametogenesis (IVG) via somatic cell nuclear transfer (SCNT); genome editing and gene correction in gametes, embryos, and cultured cells; mitochondrial replacement therapy (MRT); induced pluripotent stem cell (iPSC) and embryonic stem cell (ESC) derivation, culture, and differentiation. Department Overview:
The incumbent will provide advanced scientific expertise in genetics, epigenetics, transcriptomics, genome editing, sequencing technologies, and bioinformatics to support both research and clinical initiatives at the Center for Embryonic Cell and Gene Therapy (CECGT).
If you enjoy working in a fast-paced, multidisciplinary environment where you can directly impact how products are built and delivered at scale, this role offers broad exposure to cutting-edge synthetic biology platforms and technologies. You will play a key role in developing, optimizing, and troubleshooting workflows spanning molecular biology and mammalian cell culture systems, ensuring processes are robust, scalable, and production-ready.
Portland, Oregon24 days ago
Function/Duties of Position: Applications are invited for a Postdoctoral Research position in the laboratory of Dr. - Hosseini MH, Kurtz SE, Abdelhamed S, Mahmood S, Davare, MA, Kaempf A, Elferich J, McDermott JE, Liu T, Payne SH, Shinde U, Rodland KD, Mori M, Druker BJ, Singer JK, Agarwal Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes.
Portland, Oregon30+ days ago
Key duties include independently designing, developing, and executing gene editing, sequencing analyses and computational workflows, as well as building and maintaining bioinformatics pipelines, tools, and software for the analysis of high-throughput sequencing data derived from research participants, gametes, preimplantation embryos, and pluripotent stem cells. - Independently design, develop, and implement computational tools, pipelines, workflows, and software packages to discover, analyze, and annotate genomic information from high-throughput sequencing data, including bulk and single-cell datasets derived from research participants, gamete donors, gametes, preimplantation embryos, and pluripotent stem cells.
Hillsboro, Oregon30 days ago
Molecular Vision Laboratory (MVL), a CLIA-certified clinical service laboratory/molecular diagnostic laboratory based in Hillsboro, Oregon, is working on rare genetic conditions with the focus on eye diseases. MVL is part of Centrillion Biosciences, which has advanced research laboratories in US, China, and Taiwan for conducting research, development and commercialization of novel technologies in bioinformatics, genomics, chemistry, biochemistry, and molecular biology.
p>(https://science.oregonstate.edu/strategic-plan-2022) sets strategic priorities for the College in alignment with the University's strategic plan, Prosperity Widely Shared (https://leadership.oregonstate.edu/strategic-plan). Our diverse research portfolio includes federally funded research centers and core facilities, and scientific expertise in signature areas of biohealth and biomedical sciences, genomics and bioinformatics, sustainable materials research, climate, marine and coastal sciences, quantitative, computational and data sciences, and science education research.