Principal Electrical Engineer Advanced Energy Industries IncPrincipal Electrical EngineerWilmington, MA$165,000–$215,000 / yearThis is an exciting opportunity for an experienced engineer who enjoys solving complex technical challenges, leading high-impact projects, influencing product innovation, and working closely with customers to develop solutions that make a real difference. Leveraging your technical expertise and systems-level thinking, youll identify design challenges, recommend innovative solutions, and evaluate how engineering decisions impact product performance, manufacturability, reliability, and the overall customer experience.
Principal Product Manager - Marketing McKinsey & Co IncPrincipal Product Manager - MarketingBoston, MAYour work requires you to lead cross-functional alignment across product, engineering, solution architecture, marketing experts, and client teams to ensure pilot learnings are successfully codified into repeatable product capabilities. Experience in product management, including ownership of product vision, roadmap, prioritization, and stakeholder alignment, with track record of building and scaling products to become repeatable, market-ready solutions.
Principal Cloud Engineer TetraSciencePrincipal Cloud EngineerBoston, MADeep, hands-on AWS experience: Serverless Architecture, EKS/ECS, VPC/networking, IAM, KMS, CloudWatch, Lambda, S3, EC2, Kinesis, Athena, Glue, CloudTrail, CostExplorer. If your background is primarily in manual server provisioning, ticketing-system-driven change management, desktop support, or on-prem datacenter administration, if you always deploy someone else's code via IaC, this is not the right fit.
Electrical Engineer (Senior/Staff/Principal) NanopathElectrical Engineer (Senior/Staff/Principal)Cambridge, MAWe aim to replace lengthy molecular testing workflows by bringing rapid, high-quality diagnostics closer to the patient. At Nanopath we are dedicated to building a diverse and inclusive workplace, so if you’re excited about this role but your past experience doesn’t align perfectly with every point in the job description, we encourage you to apply anyways.
Principal Component Engineer Mercury Systems IncPrincipal Component EngineerAndover, MAJob Summary: Mercury Systems has a great opportunity for an electrical engineer who specializes in Component Engineering to make an impact, and the ability help mature our component process and framework right away. Collaborate closely with the customer, other government agencies, and cross-functional teams to resolve supply chain issues, review, improve, and document PMP activities, and ensure compliance with contractual obligations.
Staff/Principal Full Stack Blockchain Engineer GromaStaff/Principal Full Stack Blockchain EngineerBoston, MARemote$150,000–$250,000 / yearAs the primary owner for Groma's onchain tech stack, we're looking for someone that has spent enough time in the space to have developed the wisdom to see around corners and guide the team in the right direction, paired with significant hands-on experience building, deploying, and maintaining smart contracts in a production environment on EVM networks (Ethereum and Base) and connecting them to backend and frontend interfaces. 1 floating holiday: We recognize that there are lots of holidays that are meaningful to different people in different ways and we want to celebrate that by enabling team members to have the time/space to commemorate those days however is appropriate, and using it as an opportunity - if they’d like to - to share the meaning of that day with the broader team.
Sr. Principal Scientist / Director, Dmpk & Bioanalytical Sciences AlltrnaSr. Principal Scientist / Director, Dmpk & Bioanalytical SciencesCambridge, MA$179,000–$236,000 / yearThe company's initial therapeutic programs are designed to restore full-length protein production in diseases caused by premature termination codons (PTCs), collectively referred to as Stop Codon Disease, which affects approximately 10% of people with a rare genetic disease. Reporting to the Chief Scientific Officer, this role leads DMPK and bioanalytical strategy across nonclinical and clinical programs, operating as a hands-on scientific leader.
NewPrincipal IT Security Project Manager Bullhorn IncPrincipal IT Security Project ManagerMA$144,000–$170,000 / yearProgram Leadership: Direct large-scale cross-functional security projects, such as large scale software hardening, identity management rollouts, cloud security implementations, or zero-trust implementations. A Principal IT Security Project Manager leads complex, enterprise-wide cybersecurity initiatives and manages strategic security programs from planning to completion.
AI Technical Lead (Principal Engineer) EverQuoteAI Technical Lead (Principal Engineer)Cambridge, Massachusetts$202,800–$238,600 / yearEverQuote is a leading AI-powered growth solutions partner for regulated property and casualty insurance entities, enabling the largest insurance carriers and thousands of agents to maximize customer acquisition across digital channels. We intend to run and tune our own open-weight models rather than depend only on hosted APIs, so we control cost, speed, and behavior as volume grows, and owning that is central to this role.
Principal Scientist - Drug Discovery (Diabetes) Novo Nordisk ASPrincipal Scientist - Drug Discovery (Diabetes)Waltham, MA$185,000–$230,000 / yearInternal relationships include working closely with technical staff & other members of the scientific leadership team; regular collaborations with members of other research departments at Novo Nordisk; & frequent interaction with project managers & other colleagues across global R&D. With your translational mindset and background within Diabetes and metabolic disease, you will be responsible for the establishment and utilization of relevant molecular approaches, cellular assays, and read-outs in order to investigate the mode-of-action of novel drug candidates and to progress our research projects.
Principal Mechanical Engineer RE Build Manufacturing, LLCPrincipal Mechanical EngineerMerrimack, NHWe operate an advanced, end-to-end manufacturing platform that partners with industrial companies and innovators to take products from first concept to full-scale production in critical verticals including aerospace and defense, electrification, medical, energy and environment, and robotics and automation. Export Control Requirement: Due to applicable export control laws and regulations, candidates must be a U.S. citizen or national, U.S. permanent resident (i.e., current Green Card holder), or lawfully admitted into the U.S. as a refugee or granted asylum.
Principal Embedded Firmware Engineer RE Build Manufacturing, LLCPrincipal Embedded Firmware EngineerWilmington, MA$165,320.12–$247,980.18 / yearExperience developing device drivers and applications in embedded Linux runtimes (Raspbian, Yocto, Ubuntu, or others) to enable communications between microcontrollers and external hardware peripherals Implementation of a variety of runtime environments (FreeRTOS, Zephyr, others), as well as bare-metal programming. Pioneer Best Practices: Champion and implement cutting-edge best practices across the firmware development lifecycle, including advanced source code management, robust version control, streamlined DevOps, and comprehensive automated testing strategies.
Principal Associate II, Quality Systems ReplimunePrincipal Associate II, Quality SystemsFramingham, MassachusettsThe RPx platform is designed to have a unique dual local and systemic activity consisting of direct selective virus-mediated killing of the tumor resulting in the release of tumor derived antigens and altering of the tumor microenvironment to ignite a strong and durable systemic response. Replimune’s mission is to revolutionize cancer treatment with therapies designed to activate a powerful and durable full-body anti-tumor response, boldly transforming cancer care because patient’s lives depend on it.
Principal Mechanical Engineer Boston Dynamics IncPrincipal Mechanical EngineerWaltham, MA$135,000–$180,000 / yearYou will be responsible for the technical leadership of specific actuator product lines, ensuring designs meet all performance and reliability targets while fostering the professional growth of a team of design engineers through the rigor of production release. What You Bring: Production Rigor: A track record of bringing complex electromechanical assemblies from architecture through production release in high-rigor environments (e.g., automotive, aerospace, or medical devices).
Principal Software Escalation Engineer Palo Alto Networks IncPrincipal Software Escalation EngineerBoston, MA$147,000–$237,500 / yearOwn the R&D Escalation Strategy: Act as the single accountable authority for technical escalations, replacing reactive "ping-pong" with a structured, predictive pipeline that restores delivery predictability to the sprint teams. Influence the Roadmap: Use data from the field (trends, escaped bugs, and friction points) to drive strategic roadmap decisions, ensuring we prioritize technical debt and usability improvements alongside new features.
CASTLE Aide/ESP - Neary Elementary School - Education Support Professional The Public Schools of Northborough And SouthboroughCASTLE Aide/ESP - Neary Elementary School - Education Support ProfessionalNorthborough, MAParticipate in a weekly meeting with the student support services team that includes data review, academic, social, and behavioral programming updates, and sharing of concerns. Skills, Knowledge and Ability: Skilled in implementing instructional and behavioral methods and procedures appropriate for the situation when learning or teaching new things.
Associate Principal Scientist, PharmaR&D Tempus AIAssociate Principal Scientist, PharmaR&DBoston, MassachusettsReal World Data Expertise & Technical Oversight: Lead the derivation of complex real-world endpoints using extensive coding, demonstrating deep comprehension of Tempus clinical and molecular data structures and complexity, while also serving as an expert on the methodological nuances and limitations of real-world data. Technical/Scientific Skills: Expert-level proficiency in observational late stage trial data or real-world healthcare data, specifically in designing and implementing complex time-to-event methodologies (survival analysis).
Principal Solutions Architect AWS Technical Alliances Tenable IncPrincipal Solutions Architect AWS Technical AlliancesBoston, MA$175,000–$233,666.67 / yearOwn and lead the AWS technical enablement plan - Be the "connective tissue" evangelizing, designing and delivering structured enablement programs for Tenable field SEs (TFCs) and AWS customer-facing SAs, ensuring both sides of the co-sell motion are technically aligned on Tenable solutions and joint architectures. You will be the primary technical voice for the AWS alliance - enabling Tenable field SEs and AWS SA's globally, advancing joint go-to-market motions with AWS, and shaping how Tenable''s exposure management platform is positioned alongside AWS-native services and marketplaces.
Principal Scientist/Sr. Principal Scientist, Computational Chemistry & Molecular Design Antares TherapeuticsPrincipal Scientist/Sr. Principal Scientist, Computational Chemistry & Molecular DesignBoston, Massachusetts$185,000–$240,000 / yearAs a member of a highly integrated team of medicinal chemists, machine learning scientists, structural biologists, biologists, and chemical biologists, you will apply and advance the full range of modern computational methods — structure- and ligand-based design, molecular dynamics, free energy perturbation (FEP), and machine-learning / generative approaches — to assess and prioritize targets, identify high-quality starting points, and drive lead optimization toward development candidates. Serve as the computational chemistry function lead on programs, providing integrated leadership across target validation, hit identification, hit-to-lead, and lead optimization for multiple small-molecule programs.
Program Manager, Principal - TS/SCI DCS CorporationProgram Manager, Principal - TS/SCIBedford, MA$123,639–$210,000 / yearThe DAF BATTLE NETWORK is the integrated system-of-systems fusing sensors, effectors, and sustainment grids to build situational awareness, make operational decisions, and direct the force to create needed lethal and nonlethal effects in support of the Joint Force Commander’s scheme of maneuver. The DAF PEO C3BM has the responsibility of technically and programmatically integrating the DAF’s larger system-of-systems architecture needed to deliver an integrated Command and Control (C2) core function for the DAF, Joint, and Coalition forces, by teaming with all other DAF PEOs, as needed.