Using human postmortem tissues, spatial transcriptomics, spatial proteomics, single-cell genomics, CRISPR genome engineering, and human iPSC-derived microglia and motor neuron models, our goal is to identify novel therapeutic targets that can be translated into effective immunomodulatory therapies for ALS and other neurodegenerative diseases. Cedars-Sinai offers scientists unparalleled access to ground breaking technologies, facilities, and resources for conducting research related to an impressive range of diseases and disorders, from cancer, cardiology, and digestive diseases, to genetics, genomics, neurosciences, and women's health.