We are particularly focused on three key areas: (1) circuit biology relevant to movement, memory/cognition, and pain; (2) molecular and cellular mechanisms underlying neurodegeneration and regeneration, including neuroimmune and endolysosomal mechanisms; and (3) theoretical and computational neuroscience, including models, algorithms, or theory that probe mechanisms of neural circuit function across levels of biological organization. OBI programs supporting high-risk/high-reward neuroscience (Visionary Neuroscience Program), trainee development (Sprouts Program, Neural Scientist Training Program, Travel Grant Program), multidisciplinary Research Interest Groups, and clinical research career development (Clinical Neuroscience Research Excellence Initiative).