input on development of efficient and effective modeling and simulation strategies, including population PK, exposure-response analysis, and physiologically based PK (PBPK) to support clinical trial design, justification of dosing regimen, and provide supportive evidence of efficacy and safety for regulatory submissions. Animal Models, Artificial Intelligence (AI), Clinical Pharmacology, Drug Design, Drug Discovery Process, Drug Discovery Research, In Vitro Models, Medication Safety, Molecular Modeling, Oncology, Pharmacodynamics, Pharmacokinetics, Pharmacometrics, Pharmacovigilance, Target Validation.