Working in adult Drosophila as a discovery engine, with validation in mammalian systems, we have found that cells repurpose conserved molecular machinery in unexpected ways and move signals between distant tissues - opening fresh territory in cell biology and neurobiology. With a track record of global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy and COVID-19 vaccines, Fred Hutch has earned a reputation as one of the world's leading cancer, infectious disease and biomedical research centers.