Machine Learning Scientist - Quantum Chemistry F. Hoffmann-La Roche LtdMachine Learning Scientist - Quantum ChemistrySan Francisco, CAJoin the small-molecule team within AI for Drug Discovery (AI4DD), formerly Prescient Design, at Roche and Genentech's Computational Sciences Center of Excellence as a Machine Learning Scientist / Senior Machine Learning Scientist in Quantum Chemistry. The Opportunity: Create cutting-edge solutions that combine quantum chemistry and machine learning algorithm development to model small-molecule energetics and protein-ligand interactions, from conformation and reactivity to binding affinity and free energy.
Scientist, Delivery Sciences Lipid Chemistry NewLimit IncScientist, Delivery Sciences Lipid ChemistrySouth San Francisco, CA$130,000–$171,000 / yearNewLimit is seeking a Lipid Chemist to design, synthesize, and characterize ionizable lipids, PEG-lipid Conjugates, peptide and antibody conjugates to build our targeting LNP platform with a particular focus on getting nucleic acid payloads into target cells and tissues beyond the liver. Develop conjugation chemistry that links peptides, antibodies, nanobodies, and small-molecule ligands to lipid anchors, generating building blocks for cell- and tissue-selective delivery to support tLNP research and pipeline targets.
Scientist, Delivery Sciences Lipid Chemistry NewLimitScientist, Delivery Sciences Lipid ChemistrySouth San Francisco, CA$130,000–$171,000 / yearNewLimit is seeking a Lipid Chemist to design, synthesize, and characterize ionizable lipids, PEG-lipid Conjugates, peptide and antibody conjugates to build our targeting LNP platform with a particular focus on getting nucleic acid payloads into target cells and tissues beyond the liver. Develop conjugation chemistry that links peptides, antibodies, nanobodies, and small-molecule ligands to lipid anchors, generating building blocks for cell- and tissue-selective delivery to support tLNP research and pipeline targets.
Lecturer Pool for Department of Chemistry and Biochemistry AY 26-27 California State UniversityLecturer Pool for Department of Chemistry and Biochemistry AY 26-27Hayward, CA$5,507–$6,677In compliance with state and federal crime awareness and campus security legislation, including The Jeanne Clery Disclosure of Campus Security Policy and Crime Statistics Act, the Cal State East Bay Annual Campus Security Report is available here. DUTIES OF THE POSITION: The successful candidate will teach up to 15 contact hours per week in undergraduate laboratories and/or lectures, with assignments being consistent with the candidate's expertise and training, as well as the specific needs of the Department.
Principal Scientist - Medicinal Chemistry Amgen Inc.Principal Scientist - Medicinal ChemistrySouth San Francisco, CAIn addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. Additional responsibilities may include advising supervisors and colleagues in areas of expertise; participating in national and international meetings, providing scientific results that support the generation of publications or patents, and mentoring research associates and laboratory assistants.
Analytical Chemistry Scientist Octant IncAnalytical Chemistry ScientistEmeryville, CA$135,000–$155,000 / yearIdentify, develop, and deploy chromatographic and mass spectrometric methodologies - including reversed-phase, HILIC, SFC, and 2D-LC/MS separations - to analyze small molecules to support both our in-house high throughput synthesis capabilities and ADME/PK property characterization. The Navigator is an expanding set of drug discovery and development capabilities with three interwoven components that operate together: Generative Biology - Multiplexed measurements from engineered sensors in human cells to understand cellular mechanisms.
Senior Scientist, Surface Chemistry Ultima GenomicsSenior Scientist, Surface ChemistryFremont, CA$120,000–$140,000 / yearThis role pays between $120,000 and $140,000, if performed in California, and your actual base pay will depend on your skills, qualifications, experience, and location. Experience with vapor-phase and CVD-style deposition of organosilanes, thiols, or related surface chemistries, biomaterials coatings and/or bioconjugation chemistry.
Principal Scientist, Analytical Chemistry Revolution Medicines IncPrincipal Scientist, Analytical ChemistryRedwood City, CA$190,000–$238,000 / yearThe company's RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. Design and implementation of discovery analytics, analytical data integration through collaboration with LabOS team, Data Sciences and Data Analytics functions to develop and implement automated high-throughput analytical methods that enhance efficiency and data quality.
Bioconjugate & Surface-Chemistry Consultant Astera InstituteBioconjugate & Surface-Chemistry ConsultantEmeryville, CaliforniaUnlike traditional non-profit research organizations, projects supported by Astera operate like high-velocity startups, allowing us to focus on ambitious goals, match structure to problem, and attract strong technical talent and leadership. The Astera Institute is seeking a Bioconjugate & Surface-Chemistry Consultant to advise on and develop the surface chemistry that anchors a DNA-origami structure to a device surface with controlled placement and orientation.
Assistant Professor in Chemistry (Open Area) Stanford UniversityAssistant Professor in Chemistry (Open Area)Stanford, CA$136,454–$162,039 / yearThe Chemistry Department, School of Humanities & Sciences, and Stanford University value faculty who will help foster an open and respectful academic environment for colleagues, students, and staff with a wide range of backgrounds and perspectives. Applicants should exhibit the potential to run a world-leading independent research program and should possess good communication skills and a commitment to teaching and mentoring.
Principal Scientist, Synthetic Molecule Process Chemistry, Genentech Research Genentech IncPrincipal Scientist, Synthetic Molecule Process Chemistry, Genentech ResearchSouth San Francisco, CA$144,900–$269,100 / yearEventual route selection for late stage GMP API manufacturing is also the responsibility of the Scientist and includes the concepts of safe, efficient, robust, environmentally sound chemistry and extends to the synthesis of the regulatory starting materials and establishment of a robust supply chain. Strong working knowledge of the latest developments in contemporary synthetic organic and/or process chemistry including chemo- and bio-catalysis, organometallic chemistry as well as expertise in asymmetric transformations, heterocyclic chemistry, and/or peptide chemistry.
NewScientist- Process Chemistry 10X Genomics IncScientist- Process ChemistryPleasanton, CA$123,100–$166,500 / yearThe candidate will work cross functionally with Chemistry, Microfluidics, Custom Plastic Consumables, Assay Development, and Production teams to develop, optimize, validate, and transfer new chemistries and processes required to produce 10x reagents and consumables. Individuals applying for this position must be self-starters, strategic thinkers, action driven, flexible in changing direction and methods, thrive in a fast-paced environment, excel at managing multiple priorities, succeed in communicating with all levels within the organization and provide immediate contribution.
Scientist/Sr. Scientist, Medicinal Chemistry General ProximityScientist/Sr. Scientist, Medicinal ChemistrySan Francisco, CAPROTACs or other IPMs)Contributing to hit-to-lead and lead optimization studiesMed-chem optimizations: SAR, PK/PD, strong understanding of DMPKApplicant must have experience with chemical biology techniques such as mammalian cell culture and cell-based assays (e.g., cytotoxicity assays, transfections, stable cell line generation, co-immunoprecipitation), PPI assays (e.g., BRET, APEX/BioID, AlphaScreen), or strong experience in computational chemistryNice to have:Proficiency in HTS and phenotypic assay developmentProteomics experience: PTM analysis, chemo-proteomic target deconvolution, etc. Your responsibilities will include: supervising synthetic efforts with our CROs, performing and analyzing in cellulo assays, designing and optimizing first-in-class bifunctional molecules, collaborating with our Drug Discovery and IP team on patent applications, providing input for mechanistic studies on lead drug molecules, and spearheading forays into new disease areas.
Scientist, Medicinal Chemistry General ProximityScientist, Medicinal ChemistrySan Francisco, MississippiYour responsibilities will include designing and optimizing first-in-class bifunctional molecules, assessing SAR to inform iterative medicinal chemistry optimization, supervising synthetic efforts with CRO partners, performing and analyzing in cellulo assays, collaborating with our Drug Discovery and IP teams on patent applications, and contributing mechanistic insight on lead drug molecules. Chemical biology techniques including mammalian cell culture, cell-based assays (e.g., cytotoxicity, transfections, stable cell line generation, co-IP), and PPI assays (e.g., BRET, APEX/BioID, AlphaScreen); computational chemistry experience also welcomed.
Sr. Scientist/Principal Scientist, Medicinal Chemistry General ProximitySr. Scientist/Principal Scientist, Medicinal ChemistrySan Francisco, CAYou will play a central role in molecular design of next-generation IPMs, external execution, planning compound screening in routine biophysical or cellular assays and driving data interpretation, and scientific strategy, with the chance to make an outsized impact in a fast-moving startup environment. In this role, you will work at the intersection of chemistry, biology, and platform innovation, partnering closely with cross-functional teams to advance our core discovery capabilities and drive programs from concept through lead optimization.
Scientist II/Senior Scientist, Medicinal Chemistry General ProximityScientist II/Senior Scientist, Medicinal ChemistrySan Francisco, CAYou will play a central role in molecular design of next generation IPMs, external execution, planning compound screening in routine biophysical or cellular assays and driving data interpretation, and scientific strategy, with the chance to make an outsized impact in a fast-moving startup environment. In this role, you will work at the intersection of chemistry, biology, and platform innovation, partnering closely with cross-functional teams to advance our core discovery capabilities and drive programs from concept through lead optimization.
Part-Time Lecturer Pool - Chemistry California State UniversityPart-Time Lecturer Pool - ChemistrySan José, CA$5,507–$5,959Pursuant to the Jeanne Clery Disclosure of Campus Security Policy and Campus Crime Statistics Act, the Annual Security Report (ASR) is also now available for viewing at https://www.sjsu.edu/clery/docs/SJSU-Annual-Security-Report.pdf . Candidate must demonstrate awareness of and address the needs of a student population of great diversity-including age, abilities, cultural background, ethnicity, religion, economic background, primary language, sexual orientation, gender identity, and academic preparation-through inclusive course materials, teaching strategies and advisement.
Director, CMC Process Chemistry Ideaya Biosciences IncDirector, CMC Process ChemistrySouth San Francisco, CA$206,000–$254,000 / yearRepresent DS/CMC and participate in cross functional project teams and manage multiple priorities in a fast-paced, dynamic environment and enact quick problem solving to ensure on-time supply of DS to support PK/PD, efficacy, DRF and pilot toxicology studies, IND-enabling activities, and clinical trials across a portfolio of programs. The final salary offered to a successful candidate will depend on several factors that may include but are not limited to the office location where this open position is located, the final candidates' experience within their profession, experience in the disease areas we are striving to make an impact in as a company, length of time within the industry, educational background, and performance during the interview process.
NewSenior Principal Research Scientist, Computational Chemistry Ideaya Biosciences IncSenior Principal Research Scientist, Computational ChemistrySouth San Francisco, CA$196,000–$242,000 / yearAs part of the drug discovery team, the candidate will contribute directly to target assessment and druggability analysis, perform virtual screening and structure-based modeling, and work closely with medicinal chemists to design compounds with improved potency, selectivity, functional activity, and developability (e.g., ADME/DMPK). Along with our inspiring mission, and highly collaborative and inclusive environment, IDEAYA offers a competitive total rewards package that reflects our pay-for-performance philosophy where employees are eligible to be considered for merit-based salary increases, company discretionary short-term incentive plan participation, and company discretionary stock option awards (based on board approval).
Chemistry Lab Analyst (ICP-MS) Ascend Clinical LLCChemistry Lab Analyst (ICP-MS)Sunnyvale, CA$30–$32 / hourWill operate and maintain highly complex instrumentations such as Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and Ion Chromatography (IC), as well as demonstrate proficiency on routine environmental testing, instrument maintenance and troubleshooting in accordance with protocols established by Ascend Clinical. Processes specimens, performs test preparation, specimen verification and tracking, all related clerical functions and general clean-up tasks for routine as well as high complex tests.