Principal Software Developer - Safetrace Tx Haemonetics Corp.Principal Software Developer - Safetrace TxBoston, MA$103,600–$176,400 / yearWe are seeking a Principal Software Developer to drive the technical direction of SafeTrace Tx, our industry-leading transfusion management software trusted by hundreds of hospitals to deliver complete testing and transfusion histories in a single, consolidated patient record. As a principal-level contributor, you will lead the design of scalable integrations with hospital information systems such as Epic, applying service-oriented and event-driven architecture principles to ensure reliable, real-time communication from the blood bank to the bedside.
Senior or Principal Data Scientist/Machine Learning Scientist Datalign Advisory Inc.Senior or Principal Data Scientist/Machine Learning ScientistCambridge, MAAs Data Scientist/Machine Learning Scientist, you will shape the future of how consumers connect with vetted financial advisory firms through our proprietary three-sided marketplace, leveraging data and AI-powered analytics to create meaningful one-to-one matches and improved financial outcomes. Position Overview We are seeking a Senior or Principal Data Scientist/Machine Learning Scientist to lead product-focused artificial intelligence initiatives and facilitate strategic decision-making through advanced analytics and machine learning.
Principal Data Scientist (AI-assisted Clinical Development) GenentechPrincipal Data Scientist (AI-assisted Clinical Development)Boston, MassachusettsYou have excellent collaboration skills, including statistical consulting skills, interpersonal skills to contribute effectively in cross-functional team settings, ability to influence others without authority, and ability to build strong collaborative relationships with scientific and non-scientific partners. You will partner closely with product managers, software engineers, and UX researchers to design, test, and scale statistical capabilities that unlock actionable insights from clinical, operational, and real-world data.
Principal Cloud Developer Hewlett Packard Enterprise CoPrincipal Cloud DeveloperAndover, MA$160,000–$303,000 / yearUnited States of America: Annual Salary USD 160,000 - 303,000 in Colorado // 172,000 - 328,000 in Massachusetts // 172,000 - 349,000 in California // 152,000 - 349,000 in North Carolina & Texas. Please note that Hewlett Packard Enterprise (HPE), its direct and indirect subsidiaries and affiliated companies, and its authorized recruitment agencies/vendors will never charge a candidate a registration fee, hiring fee, or any other fee in connection with its recruitment and hiring process.
Senior / Principal Associate Scientist, Advanced Cell Engineering Strand Therapeutics IncSenior / Principal Associate Scientist, Advanced Cell EngineeringBoston, MA$84,000–$112,000 / yearIts initial program, STX-001, an intratumorally delivered LNP-encapsulated self-replicating RNA expressing IL-12, has demonstrated preliminary evidence of systemic immune activation and anti-tumor activity in patients with advanced solid tumors who have progressed on prior therapies. We are looking for a Senior / Principal Associate Scientist to join the mRNA Programming department to help drive our efforts utilizing the power of RNA LNP therapeutics in oncology, autoimmune diseases, and beyond.
Principal Scientist, Machine Learning Flagship Pioneering IncPrincipal Scientist, Machine LearningCambridge, MA$208,000–$286,000 / yearTechnical Ownership: Own the build, scaling, benchmarking and maintenance of agentic systems that combine ML and computational biology tools (genomics,biomolecule design,literature mining,system biology, etc) which serve as end-toend systems for accelerating preclinical, translational and clinical R&D. Breadth across domains such as genomics, protein modeling/design, proteomics/mass spec, multi-omics, cheminformatics/docking/ADMET, biophysics/MD, and scientific literature mining, with the ability to connect them using LLM-based agents and agentic workflows.
BCG Platinion | Principal AI Tech Architect - AI Platforms Boston Consulting Group IncBCG Platinion | Principal AI Tech Architect - AI PlatformsBoston, MAOur consultants and experts globally work across all industries and provide deep experience and expertise across a number of topics including Digital Transformation, Data & Digital Platforms, AI at Scale, Agile, Cybersecurity and Digitizing the Tech Function. You'll work across AI, data, product, and engineering teams to define scalable architectures for AI-driven applications, enabling the seamless integration of large language models (LLMs), data pipelines, and enterprise systems.
Principal Data Scientist Gradient AIPrincipal Data ScientistBoston, MARemoteDeep experience being accountable for model impact long term – from MLOps pipelines to monitor for drift, to KPI and impact monitoring, driving incremental and long-term improvements, triaging issues, addressing tech debt responsibly, etc. Our platform harnesses a vast industry data lake – tens of millions of policies and claims enriched with economic, health, geographic, and demographic signals – integrating cleanly with existing workflows to make complex risk clear, usable, and actionable.
Principal Scientist, Antibody Discovery and Engineering Moderna IncPrincipal Scientist, Antibody Discovery and EngineeringCambridge, MA$142,500–$256,500 / yearThis individual will operate with a high degree of independence, scientific judgment, and cross-functional influence while partnering with antigen design, structural and computational biology, Immuno-oncology and Autoimmune Therapeutics research leadership, project teams, and external CRO partners. We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities.
Principal Software Developer - SafeTrace Haemonetics CorpPrincipal Software Developer - SafeTraceBoston, MA$103,600–$176,400 / yearWe are seeking a Principal Software Developer to drive the technical direction of SafeTrace Tx, our industry-leading transfusion management software trusted by hundreds of hospitals to deliver complete testing and transfusion histories in a single, consolidated patient record. As a principal-level contributor, you will lead the design of scalable integrations with hospital information systems such as Epic, applying service-oriented and event-driven architecture principles to ensure reliable, real-time communication from the blood bank to the bedside.
Principal DevOps Architect Harvard Business PublishingPrincipal DevOps ArchitectBoston, MA$160,000–$175,000 / yearAs a key member of the Technology Operations leadership team, you will define and lead our DevOps strategy-partnering closely with engineering, cloud operations, and security to deliver secure, reliable, and scalable platforms. Partner with software engineering and product teams to translate delivery needs into an efficient CI/CD ecosystem-recommending, selecting, implementing, evolving, and optimizing tools and practices.
Principal Solutions Architect (Databricks) Blue Orange Digital LLCPrincipal Solutions Architect (Databricks)Boston, MAYou can whiteboard a multi-workspace Unity Catalog governance model, explain when Photon earns its cost, diagnose a skewed join from a Spark UI screenshot, and reason about Delta Lake file layout and liquid clustering under real workloads. Hands-on command of Spark, Delta Lake, Unity Catalog, Databricks Workflows, Delta Live Tables, MLflow, and Mosaic AI, plus fluency in at least one major cloud (AWS, Azure, or GCP) and infrastructure as code.
Principal Scientist, Computational Protein Design Moderna IncPrincipal Scientist, Computational Protein DesignCambridge, MA$142,500–$256,500 / yearWe are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. This individual will work in close partnership with structural biology, directed evolution, immunology, translational science, and program teams to advance platform innovation and therapeutic programs across Moderna's Research and Early Development portfolio.
Principal Scientist, Machine Learning Flagship Pioneering, Inc.Principal Scientist, Machine LearningCambridge, MA USA$208,000–$286,000 / yearBreadth across domains such as genomics, protein modeling/design, proteomics/mass spec, multi-omics, cheminformatics/docking/ADMET, biophysics/MD, and scientific literature mining, with the ability to connect them using LLM-based agents and agentic workflows. We are seeking a Principal Scientist (Embedded ML/Computational) to lead AI/ML and computational projects that accelerate pharmaceutical R&D across the preclinical, translational, and clinical continuum, working closely with Pioneering Medicines (PM) and across Flagship’s platform companies as part of the company origination process.
Principal Product Manager, AI Infrastructure and Orchestration DataRobot IncPrincipal Product Manager, AI Infrastructure and OrchestrationBoston, MAIt does not own agent coordination and authoring (planner and router logic, memory strategy, multi-agent handoff, builder surfaces), workflow orchestration in the Airflow or Temporal sense, model quality and applied research, or cluster fabric work such as InfiniBand and RoCE tuning for distributed training. Deep technical understanding of GPU and accelerator behavior: topology-aware placement, fractional and time-sliced sharing, MIG, device plugins and the driver and container runtime plumbing underneath them, memory as the binding constraint, and what utilization costs when a tenant holds a GPU it is not saturating.
Principal Signal Processing Engineer - Cardiac Ablation Solutions MedtronicPrincipal Signal Processing Engineer - Cardiac Ablation SolutionsNewton, MassachusettsIf you are applying to perform work for Medtronic, Inc. (“Medtronic”) in any position which will involve performing at least two (2) hours of work on average each week within the unincorporated areas of Los Angeles County, you can find here a list of all material job duties of the specific job position which Medtronic reasonably believes that criminal history may have a direct, adverse and negative relationship potentially resulting in the withdrawal of a conditional offer of employment. The following benefits and additional compensation are available to those regular employees who work 20+ hours per week: Health, Dental and vision insurance, Health Savings Account, Healthcare Flexible Spending Account, Life insurance, Long-term disability leave, Dependent daycare spending account, Tuition assistance/reimbursement, and Simple Steps (global well-being program).
Principal Software Engineer, Data Lila Sciences IncPrincipal Software Engineer, DataCambridge, MA$204,000–$348,000 / yearWe are seeking Principal Software Engineers with backend experience to join our Data Platform Team (Data), where you'll collaborate with software engineers, lab scientists, and machine learning engineers to build cutting-edge tools for automated scientific analysis and more. Full-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program.
Principal Product Manager, Customs & Border Authorities Altana AIPrincipal Product Manager, Customs & Border AuthoritiesBoston, MASupply chain transparency requirements, forced labor enforcement, fentanyl and precursor interdiction, tariff volatility, revenue leakage, and the pressure to facilitate ever-growing trade volumes with flat resources - customs and border authorities around the world are being asked to do something they've never been equipped to do: understand, monitor, and act on the full depth of global commerce, not just the edge of it. You will own the product vision across Altana's core customs offerings: the Altana Passport Manager, which lets authorities pre-clear goods before they ever arrive; the Altana Entry Processing System, which brings sophisticated AI to entry review at the speed and scale of live trade; and the Altana Trade Enforcement Suite, which powers enforcement and revenue protection from counternarcotics to undervaluation.
Manager, Software Engineering Vestmark, Inc.Manager, Software EngineeringBoston, MA$155,000–$165,000 / yearVestmark is a leading provider of wealth management solutions and services that enable financial advisors and institutions to efficiently manage and trade their clients' portfolios using a purpose-built SaaS ecosystem. Lead a team building AI-native systems in production, in a domain where the business consequences are direct and measurable: $2 trillion in assets, millions of accounts, and a business model that is actively transforming.
Principal Product Manager, Software: Identity, Security and Compliance SonosPrincipal Product Manager, Software: Identity, Security and ComplianceBoston, MassachusettsHands-on experience using AI tools (e.g., for research synthesis, spec drafting, data analysis, prototyping, or workflow automation) to move faster and work leaner — and genuine enthusiasm for continuing to evolve how PM work gets done. Define and champion the vision, roadmap, and success metrics for global identity management, platform security, and regulatory compliance within the Sonos software ecosystem — including authentication, authorization, data privacy (e.g., GDPR, CCPA), identity profiles and roles, and related critical initiatives.